Excerpts

We correlated the expression of CSF1R with the tumor-associated macrophage gene set and observed a highly significant positive correlation for all 37 genes ( Supplementary Table S1 ).

Patients with strong expression of CXCR-4 end VEGF receptor-3 showed a trend toward better OS when treated with FPL.

Therefore, it seems that post-RT extractions no longer involve this risk, unlike pre-RT extractions, which despite a decreasing trend, still show a certain percentage of ORN, and this has been observed in recent studies too (e.g., 7.6% in Schuurhuis, 2011 and 13% in Batstone, 2012) [ 32 , 33 ].

showed at least a weakly significant advantage of combined doxorubicin-based over doxorubicin alone chemotherapy in 5044 patients [ 47 ].

While OS showed a trend towards superiority in the higher testosterone group, the results were not statistically significant.

In contrast to previous work where UDCA treatment showed a trend toward attenuation of tissue loss in the rat Yoshida hepatoma model [ 76 ], we observed a significant drop in the tibialis weight in C26-UDCA mice.

They found that a high number of nitric oxide synthase 2 (INOS+) M1-like macrophages, both inside the tumor and at the invasive margins, was significantly associated with better OS, whereas the presence of CD163+ M2-like macrophages, inside the tumor, showed a trend toward poor prognosis [ 46 ].

Cap-chaperones, including CBC and eIF4E, are likely to be significant contributors to APA regulation as well as its dysregulation in malignancies. 2.4.

Figure 1 B illustrates other, highly significant differences in mutation frequencies between the Notch-mutated and the non-mutated subgroups.

Patient-specific models of apoptosis execution, based on the concentrations of these molecules determined in samples of stage II and III colorectal tumors, showed a trend towards impaired apoptosis execution with advanced disease stage and correlated with disease relapse after adjuvant chemotherapy.

A recent systematic review on the effect of prehabilitation on postoperative complications after hepatopancreatobiliary surgery showed a trend towards complication reduction.

However, there was a clear trend towards overexpression of TM4SF1 and IGFBP3 in patients with poor outcome.

Considering genomic disruption levels of disease-free CTCs and relapsed patients CTCs, we observed a highly significant difference between the two groups.

Since the purity corrected p -values were still highly significant for CD74, it is indicated that CD74 is marker of immune infiltration in breast cancer, but from these results, it is hard to pinpoint a certain immune cell type it is associated with.

While RT-ddPCR analysis of hsa_circ_0001275 expression in plasma samples of 44 clinical trial participants showed a trend that mirrored the stages of disease activity (as defined by PSA level), the association did not reach statistical significance.

As expected, there was a highly significant overlap between differentially expressed genes, either from CTCF overexpression ( Supplementary Figure S7A,B ) or CTCF knockdown ( Supplementary Figure S7C,D ) and genes nearby to CTCF binding motifs within accessible chromatin from untreated cells ( Supplementary Figure S7A,C ) or from cells treated with TGFβ for 10 days ( Supplementary Figure S7B,D ).

In addition, there is an obvious trend towards higher missing-data rates in the longer-term follow-up.

However, Equation (3) was selected for further evaluation, since Figure 3 B shows a weak trend that using Equation (4), temperatures along the thermometry probe decrease slightly, and since the risk of not finding a solution was slightly lower in case of Equation (3).

This indicates a mild trend that planning-based steering yields a slightly larger reduction in hot spot temperature.

On the other hand, there was a strong trend with RadScopal treatment with or without immunotherapy to increase CD4 + T-cells ( Figure 4 A) that were not Foxp3 + Tregs for most ( Figure 4 B).

A more precise analysis of the immune cell subtype showed a trend towards increased infiltration of cytotoxic T lymphocytes and of TAMs within the EE group ( Figure 5 C).

IL-5 was significantly decreased in the tumours of the EE group compared to the SE group ( Figure 6 B), IL-4 also showed a decreasing trend ( Figure 6 D).

Engagement of OX40/CD134 on human NK cells with an agonistic MoAb augmented ADCC capacity and IFN-γ secretion and showed a trend towards greater TNFα release.

In addition, both scores in each group showed a decreasing trend over time. 3.3.

Furthermore, when involved versus extended field radiation therapy or different levels of radiation dose (<2000 cGy, 2000 to <3600 cGy, or >3600 cGy) were analyzed, there was a trend toward significance for radiation field extent.