Excerpts

Conventional systemic therapy with nitrosoureas and temozolomide rechallenge has limited efficacy, thus leading to an increasing trend toward precision medicine and targeted therapy for GBM.

However, because of design flaws, small but possibly significant differences in long term outcomes must be taken into consideration and more trials may be necessary.

This suggests that very long-chain SFAs may be significant in glioblastoma aggressiveness.

A clear trend towards increased R1 rates in mutRAS patients was demonstrable across all studies, with R1 resection rates in the mutRAS group ranging from 3.2% to 41%, and in the wtRAS group from 2.6% to 29.6% ( Table 3 ).

Time Trends Analysis The total number of resected NF-PanNETs showed an increasing trend over the 15-year study period, from 5 resections in 2006 to 94 resections in 2020, with an annual growth rate of 5.93% ( Figure 2 A).

In addition, μCBV showed a trend of being higher in GBM (IDH-wt) compared to Astro (IDH-mut); however, this did not reach the statistically significant level ( p = 0.12) ( Figure 2 ).

Interestingly, the changes in tumor uptake at early [ 18 F]-ML-10 PET showed a highly significant correlation with those measured on MRI 6–8 weeks later.

Splitting the data on the basis of tertile values, a clear trend emerged ( Figure 5 B).

The positive association between gene expression and patients’ survival was confirmed by the highly significant linear trend in both OS and EFS observed including in the Cox model the original continuous values of CCSER2 expression.

A test probability of p < 0.05 was defined as statistically significant whereas a test probability of p < 0.01 was defined as highly significant. 4.

In the largest single-center analysis of 1294 patients, inflammation markers were compared and a new highly significant combined score, termed the inflammatory benchmark index (IBI), comprising five inflammatory markers was developed.

In our totally occluded model (the RLL), the trends among the times of StO 2 % and deoxy-Hb showed a clear trend that could be applied in operating rooms to estimate congestion.

Patients who had preoperative plus postoperative radiotherapy showed a trend toward superior local control.

CA 19-9 36 U/mL had marginal significance as a prognostic factor.

They did not find any significant difference in ADR between both groups of endoscopists, and a nonsignificant trend was found in both HDs and LDs when CADe was used.

However, patients with a high level of VISTA-expressing cancer cells (VISTA + PanCK + ) showed a trend towards worse overall survival ( Figure 3 C and Supplementary Figure S1C ).

However, there is a clear trend that TATE is associated with a favorable outcome in many cancers, including HNSCCs [ 88 , 89 , 90 ].

A study using the 45 North American Association of Central Cancer Tumor Registries demonstrated an increasing trend of NCGC incidence in younger individuals, with the trend being more pronounced in women than men [ 9 ].

Introduction Keratinocyte carcinomas (KCs) are the most prevalent form of cancer worldwide, and their incidence is rising dramatically, with an increasing trend in recent years.

Treatment with NVS-PAK1-1 showed a trend without obvious systemic toxicity in inhibiting NF2 [ 239 ].

While the survival data for grade 1–3 ( Figure S1 ) and GBM ( Figure S2 ) show no significant difference, there was an observed trend of low sortilin levels associated with longer survival times (13 months and 1.5 months, respectively). 3.3.

Though relatively small in magnitude compared to the treatment dose [ 33 ], there is an increasing awareness that the cumulative dose may be significant, particularly in pediatric patients due to the concern for late effects and the distribution of the radiation doses [ 34 ].

[ 7 ] found a positive trend in favour of the prospective cohort that underwent pharmaceutical consultations compared with the retrospective cohort that did not receive any consultations; however, the finding was not significant (61.5% vs 53.0%, p = 0.07).

The mortality rate of oral cancer showed a decreasing trend, while the rate related to tobacco chewing showed a significantly increasing trend.

There were only 3 multicenter studies, and had the peculiarity of being performed after 2018 (one in 2018, one in 2021, and another in 2022) [ 36 , 39 , 40 ], all showing a positive trend towards collaboration in identifying the correct strategy in this particular scenario.