Artemisinin derivatives differently affect cell death of lung cancer subtypes by regulating GPX4 in patient-derived tissue cultures.

Cell Death Discov · 2025 · PMC12119945 · PMID 40436830

Europe PMC DOI

hedged sentences

—

closest p

—

boldest claim

The sentences

did not reach statistical significanceno p-value reported

Although tumor cell apoptosis did not reach statistical significance, three PDTC did show robust alterations when supplemented with DHA and ATS.

also in 111,027 other papers

a clear trendno p-value reported

CTR)) as well as a clear trend towards enhanced GPX4 expression was observed with ATS (median: 270% (20 μM)).

also in 19,460 other papers

an elevated trendno p-value reported

Median values of the lower concentrations ( n = 9–11) showed an elevated trend in comparison to the control condition (DHA: 131%,10 μM; ATS: 137%, 20 μM; ART: 103%, 100 μM; ATM: 121%, 50 μM) while the higher concentrations ( n = 4) do not show elevated fractions of tumor apoptosis (DHA: 77%,30 μM; ATS: 104%, 40 μM; ART: 54%, 200 μM; ATM: 72%, 100 μM Fig. 1B ).

also in 278 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.