A real-world analysis of stereotactic body radiotherapy combined with immunotherapy in advanced or recurrent non-small cell lung cancer (NSCLC): A single-center experience.

Multiple progression contributed to poorer OS though barely failed to attain statistical significance (HR, 3.26; 95 % CI, 0.94–11.28; p = 0.062).

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Comparing to treating only part of metastatic lesions, total irradiation of metastatic lesions was associated with superior PFS (HR, 0.44; 95 % CI, 0.18–1.11; p = 0.083), and higher radiation doses (BED 10 ≥ 60 Gy) showed a favorable trend to improve the PFS (HR, 0.71; 95 % CI, 0.36–1.39; p = 0.319).

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In our results, radiation regimens with BED 10 ≥ 60 Gy, for instance, 10 Gy × 3 regimen, showed a pronounced trend to improve the outcomes comparing to those with lower BED 10 in both Group 1 and 2.

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Univariate and multivariate analysis for PFS and OS As shown in Table 2 , in Group 1, multiple metastases were associated with poor PFS (HR, 3.59; 95 % CI, 1.89–6.83; p < 0.001), so as the squamous cell carcinoma (HR, 1.92; 95 % CI, 0.96–3.81; p = 0.064) with a borderline significance.

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While in Group 2 for whom received salvage SBRT to the progressed tumors, it seemed that there was barely significant factor correlated with treatment outcomes.

also in 875 other papers