Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.

Both pathways were also strongly affected by 2c treatment in old fibroblasts but did not reach statistical significance (FDR > 0.05).

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Furthermore, we noticed a marginally significant elevation of splicing-related damage with age, whereas the relative proportions of alternative splicing events remained unchanged.

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We have also attempted to establish aging-related differences at the phosphoproteome level, particularly in regards to mitochondrial processes (see figure below), but only GOcc: mitochondrion and GObp: mitochondrial transport come close to being statistically significant (raw p-values of 0.05 and 0.08, respectively) in the control comparison.

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