Furthermore, in the different multivariate regression models, FGF-23 was not independently associated with CVD after adjusting for confounders (Although a LVEF < 45% showed a trend toward an independent association with FGF-23, OR: 0.51 (0.26-1.00; p = 0.053, Table 4 ).
Notably, low expression of pro-apoptotic Mcl-1S isoform showed a trend towards positive significance with poorly differentiated tumors (p = 0.053).
Heart rate changes showed a trend ( p = 0.053) but did not reach statistical significance between groups ( Table 5 ). 3.4.
Glucose levels showed a trend toward correlation with age ( r = 0.22, p = 0.053; Figure 2c ) but no significant sex difference ( p = 0.46; Figure 2f ) or correlation with chlorpromazine equivalents ( r = 0.11, p = 0.36; Figure 2i ), while they were significantly correlated with imipramine equivalents ( r = 0.29, p = 0.034; Figure 2l ).
However, it is important to point out that the amygdala showed a trend of significantly greater indirect connections to both the ACC ( p = 0.053) and the STP ( p = 0.051).
Meta-analysis showed a trend for the intervention to reduce fractures (OR 0.60, 95%CI 0.36 to 1.01, P=0.053).
The Reward*Time*Group ANOVA revealed that reaction times differed significantly between coin and circle (main effect Condition: F (1, 82) = 22.78, p < .001, see Fig 1C ) and showed a trend-wise decrease following a reversal (main effect Time: F (3, 246) = 2.6, p = .053).
Participants showed a trend toward committing more errors during color than repeat trials F (1, 40) = 3.97, p = 0.053, and they also reported being aware of more errors during color than during repeat trials F (1, 38) = 14.32, p = 0.001.
Fever ( t > 38.5°C) only showed a trend toward a higher rate of blood culture positivity ( P = 0.053).
By RT-PCR, E-cadherin mRNA levels were not statistically different in primitive streak or in preingression epiblast regions of control versus treated embryos (Figure 4I ), though mRNA levels in the isolated preingression epiblast of SU5402 treated embryos showed a trend towards being reduced (p = 0.053).
The combination therapy showed a trend towards longer time without cancer recurrence compared to monotherapy (with a hazard ratio for recurrence or death being 0.561 [95% CI 0.309–1.017]; p = 0.053), and fewer patients experienced cancer recurrence or death (22% in the combination group vs. 40% in the monotherapy group).
A direct comparison of the two active patterns (Additional file 1: Table S4) indicated comparable risks for most outcomes, except for myocardial infarction, where concentrated activity showed a trend toward a higher risk (HR 1.19, 95% CI 1.00–1.42, P = 0.053).
Lambda (the path length normalised for network size and connectivity), as a measure of global network integration, showed a trend for a difference in trajectories over the 24-week study period in the beta band (MMRM, F(2,279) = 2.97, p = 0.053; ICC = 0.083) (See Table 4 and Figure 5 ).
Further subgrouping of the cohort revealed that in the ER-negative group of patients CAV1 expression displayed a trend for longer DFS ( P =0.069), whereas CAV2-positive cases showed a trend for shorter BCSS ( P =0.053).
Univariate analyses using the cox regression analysis ( Tables S1 – S5 ) revealed that recurrence was a significant prognosticator for PFS (HR, 3.986; 95% CI: 1.246–12.754, p = 0.020); salvage IMRT is a significant predictor for PFS (HR, 3.009; 95% CI: 1.007–8.991, p = 0.049); the use of ENI significantly improves LPFS (HR, 0.136; 95% CI: 0.019–0.964, p = 0.046); recurrence showed a trend to predict DMFS (HR, 5.373; 95% CI: 0.981–29.426, p = 0.053), and OS (HR, 5.886; 95% CI: 0.931–37.231, p = 0.060); salvage IMRT showed a trend to predict LPFS (HR, 5.840; 95% CI: 0.821–41.522, p = 0.078).
A haplotype of all four investigated SNPs (rs3212227-rs17860508-rs10045431-rs6887695) showed a trend for association with CD (p = 0.053); however, this potential association signal did not reach statistical significance and was uncorrected for multiple testing.
However, SLC6A4 TC/CC carriers showed a trend for softer stools (according to the BSS) compared with TT carriers ( P = .053). 3.8 Impact of DNA variants on transcription factor binding capacity We performed comparative transcription factor binding site analysis in the major and the minor (protective) haplotype genomic regions where the tag SNP rs2020938 resides.
Using the more conservative negative binomial approach (also robust to overdispersion) results were consistent: CALS remained significantly associated with the number of medications (IRR = 1.26; 95% CI [1.13–1.40]; p-value < 0.001) and showed a trend-level association with total alerts (IRR = 1.06; 95% CI [0.999–1.124]; p-value = 0.053).
In multivariate analyses, the female sex was independently associated with reduced all‐cause death (aHR 0.59; 95% CI 0.38–0.91, p = 0.019) and showed a trend toward higher AFDAS risk (aHR 1.57; 95% CI 0.99–2.49, p = 0.053).
Assessment of the regulatory CD25+FoxP3+ population also showed a trend for an increased frequency in the CD4+ subset ( p = 0.053) ( Figure 3C ) and an increased frequency for the CD4-CD8- subset ( p = 0.036) ( Figure 3D ) for patients ( n = 16, P5-20) compared to controls ( n = 20).
In addition, the HC participants who performed the DG task also showed a trend toward the KYNA/KYN ratio ( r = −0.334, P = 0.053).
Multivariable Cox Proportional Hazards Regression In multivariable Cox proportional hazards regression analysis adjusting for age, sex, and level of obstruction, secretory obstruction (vs structural obstruction) showed a trend toward lower failure risk in the secretory group compared with the structural group (HR, 0.28; 95% CI, 0.077–1.015; p = 0.053) ( Table 3 ; Supplementary Figure S1 ). 4.
The percentage, but not the number, of CD163 + macrophages in BAL showed a trend for correlation with sputum (Rs = 0.267, p = 0.053).
In the univariate analysis of the first-line setting, luminal A subtype showed a trend towards a correlation with a longer PFS ( p = 0.053).
District-level variation showed a trend toward statistical significance ( P = 0.053), indicating possible spatial heterogeneity in BTV exposure.