Caspase genes (CASP 4, 6 and 8) and other signaling pathway genes important for inflammation (MAPK1, MAPK13, IRF1 and NLRX1) also showed a trend of increased expression at the hepatic phase ( Table 2 ).
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43 With the TCGA breast cancer data set, higher expression of NSD1 showed a trend toward better overall survival when all tumor subtypes were considered ( Figure 6c ) and significant survival advantage in HER2-negative patients (135 high and 134 low expression cases, Figure 6d ).
BG particles showed a trend towards increased cell survival with ZA treatment; however, interpretation was confounded by the decreased cell numbers seen with BG alone.
With regard to comorbidity, the presence of renal failure and dyslipidemia showed a trend towards greater participation, but not significant (p = 0.089 and p = 0.09).
Both findings were most evident in the first block after rTMS, and the measures either fully returned to baseline (230–340 ms) or showed a trend toward baseline (550–750 ms), which argues against non-specific effects such as practice or vigilance.
However, a randomized, double-blind, placebo-controlled study showed a trend toward fewer and milder rejections during the first 6 months in the rituximab group with no increase in infectious complications [ 5 ].
The measurement of the lumen diameter showed a trend towards a smaller lumen in the ACTA2 mutant, although the majority of the small arteries appeared to have lumens comparable to those in the control case.
In addition, despite the different levels at 24 and 48 h of co-cultures, each mediator showed a trend and a significant difference in both determinations (data not shown).
97 One recent large randomized trial of 338 patients with inflammatory bowel disease and iron deficiency anaemia (Hb <12 g/dL and TSAT <20%) showed a trend to improved efficacy with oral iron (iron sulfate 200 mg/day) vs. i.v. iron isomaltoside 1000 in terms of the primary efficacy endpoint of change in Hb from baseline to week 8 ( P = 0.09), but patients with known intolerance to oral iron were excluded and i.v. iron dosing may have been inadequate;
Memantine treatment markedly inhibited tau hyperphosphorylation except some tau sites, which showed a trend of decrease ( Fig 4A and 4B ).
The Bland-Altman plot of Fitbit versus manual step count showed a trend towards larger differences at higher step counts, but agreement at lower step counts (Figure 1 ).
Even though not significant in the relatively small sample size, patients with pruritus showed a trend of higher scores on Skindex-16 and FACT-EGFRI-18 (indicating a lower HRQoL) than patients with papulopustular eruption or xerosis.
Sub-analysis comparing only non-vestibular and lesions group data showed a trend toward a difference in acceleration step gain between ipsilesional and contralesional sides (both left and right sides were pooled for the non-vestibular group) (ANOVA: sameside , P = 0.0798, η 2 = 0.017).
Compared to patients on placebo, patients receiving Idebenone showed a trend for improvement of peak systolic radial strain in the left ventricular inferolateral wall, the region of the heart that is earliest and most severely affected in DMD.
Despite these biochemical and ultrastructural changes though, echocardiography of animals 24 h after LT challenge only showed a trend in reduced LVEF.
Although MoDCs exposed to bLF showed a trend towards a higher accumulation of CCL1 mRNA at both time points assessed (4.6 and 5.3 fold increase at 2 and 4 h post treatment, respectively), the differences did not reach statistical significance ( Figure 2 B). 2.2. bLF-Mediated Up-Modulation of CCL1 Secretion Requires Different Receptors in Mo and MoDCs LF can interact, specifically or by virtue of its highly cationic nature, with a variety of cell determinants with different grade of specificity, including molecules involved in pathogen recognition such as DC-SIGN, CD14, TLR2 and TLR4 [ 4 , 5 , 27 ].
Moreover, ZBTB12 -DMR showed a trend towards more pronounced hypomethylation in subjects with a short time to disease (TTD) both in the Italian and in the Dutch samples.
The period effects in East Asian countries showed a trend of increase during the observation period, while there was a slight decline in the U.S.
Furthermore, we found that after treatment for seven days, OB-induced behavioral deficits were normalized by TFF3, whereas venlafaxine only showed a trend but did not produce significant antidepressant-like effect.
In contrast, three genes ( 9-2 , 10-2 , and 10-3 ) showed a trend of down-regulation from 3 h to 24 h.
Creatinine clearance ≤30 mL/min showed a trend toward an association with 2-year mortality (HR, 1.36; 95% CI, 0.97–2.00).
In the Melbourne [ 14 ] and Rotterdam studies [ 11 ], males showed a trend towards increased risk of POAG which was absent in the Barbados Eye Study [ 7 ] and the Beaver Dam Eye Study [ 10 ].
We also found that Prmt6 expression showed a trend towards decreased expression over time from 1–8 weeks in postnatal testes.
Interestingly, after further dividing 1~7 days' group into 1~3 and 4~7 days' group, the former only showed a trend toward improved LVEF, but the latter still resulted in a 3.05% (95% CI, 0.92~5.25) increase for 6-month follow-up and 4.18% (95% CI, 2.30~5.84) increase for 12-month follow-up in LVEF, respectively ( Figure 2(d) ).
However, conventional MRI features like diffuse cerebellar involvement with ill-defined margins, involvement of the cerebellar gray matter, and associated leptomeningeal enhancement can help in differentiating cerebellitis (either inflammatory or demyelinating) from neoplasms.[ 14 ] Also, a close follow-up MR imaging may show complete resolution of the lesions, sometimes healing with residual cerebellar atrophy.[ 14 ] On DTI analysis, inflammatory cerebellitis showed a trend toward relatively low RA maximum (RA-max), VR maximum (VR-max), cP maximum (cP-max), and RD mean (RD-mean).