“showed a trend”

Although total survival time and post-onset survival duration were not significantly prolonged by MSC-sEV treatment, MSC-sEV treatment significantly delayed progression from a mild symptom phase (NeuroScore 1) to more severe symptoms (NeuroScore 2) compared with vehicle-treated controls and showed a trend toward slower weight loss.

YIAD-0501 showed a trend toward reduced oligomer formation and dissociation of pre-formed Aβ(pE3–42) oligomers (Fig. 2 C, Fig.

In this unadjusted analysis, no statistically significant difference in post-operative survival was detected between the two centres ( p = 0.065), although GS patients showed a trend towards longer postoperative survival, particularly within the first two years after surgery.

Additionally, PDK1 and PDK4 expression showed a trend toward correlation with aortic succinate levels, suggesting an association with macrophage-driven inflammation.

Also, at high temperature, individuals reared on a high-carbohydrate diet showed a trend toward better survival than those reared on a regular diet, but the difference is not statistically significant (Fig. 3 A, Table S6 ).

Swallowing dysfunction showed a trend toward higher malnutrition risk (RRR = 4.07), though this did not reach statistical significance ( p = 0.070).

35 They found that, compared with NIVO+RELA, NIVO+IPI had similar PFS and ORR, while BRAF/MEK inhibitors had similar PFS and significantly higher ORR; NIVO+RELA also showed a trend of fewer grade ≥3 AEs than NIVO+IPI.

However, patients with a high number and density of distal TLSs showed a trend toward better survival than those with a low number and density of distal TLS; however, this difference was not statistically significant.

Moreover, TNBC patients with low PKM expression showed a trend towards benefitting from radiotherapy not quite reaching significance, while there is no difference in response to radiotherapy in TNBC patients with a high expression of PKM (Fig. 2 H).

In survival analyses, higher CXCL11 expression was associated with worse distant metastasis-free survival and showed a trend toward poorer overall survival, whereas higher KLF2 expression was associated with better outcomes.

lagopus seedling leaves showed a trend of first decreasing and then increasing with decreasing temperature ( Figures 1A, C ).

While the 100 mg/kg dose showed a trend toward reduction, the 150 mg/kg regimen yielded a statistically significant decrease in lung viral titers compared to the vehicle control.

Even though the OS, DFS, and GRFS showed a trend in favor of the PTCY cohort, there was no statistically significant difference in these outcomes at 12 months after transplant for the PTCY and CNI-MTX cohorts, perhaps due to the limited sample size.

Reparixin showed a trend toward limiting disease progression as an add-on therapy in COVID-19 severe pneumonia ( NCT04878055 ); the results of the ARDS clinical trial have not yet been reported ( NCT05496868 ) [ 190 ].

Notably, PBMCs from patients with progressive disease also showed a trend for higher proliferation, possibly reflecting intrinsic differences in proliferative potential and anergy ( Caligaris-Cappio, 2014 ; Haselager et al., 2023 ; ten Hacken et al., 2019 ).

Although POD activity in the M8 treatment (56.22 U g −1 FW) showed a trend of recovery toward control levels, it remained statistically comparable to both the control and intermediate treatments based on post hoc letter groupings.

For example, RFX-NS showed a trend towards prolonged T max , elevated C max , and an approximately 1.29-fold increase in AUC.

Quantitative assessment of spared white matter showed a trend toward greater preservation at all distances from the injury epicenter in animals receiving the combined therapy versus untreated SCI controls, although these differences did not reach statistical significance ( Figure 3 D). 3.4.

Fecal sIgA (mg/g stool) showed a trend toward higher levels in the intervention group and lower levels in the placebo group, with one pre-specified subgroup demonstrating a significant difference in change-from-baseline (intervention +1.12 mg/g vs. placebo −1.02 mg/g).

Consistent with these findings, MRPL9-knockdown cells showed a trend toward S-phase arrest (not statistically significant), while LPCAT1-knockdown cells exhibited a significant G2-phase arrest ( Figure 8 I).

In our study, stratification by FIGO stage showed a trend toward worse prognosis for G-EAC compared with usual-type endocervical adenocarcinoma, though not statistically significant, likely due to limited follow-up and sample size.

In response to T COVID , MSCs showed a trend to elevated levels of IL-6 ( Figure S3a , mean 23.337 ± SEM 24.725, n = 3), IL-1β ( Figure S3b , mean 27.877 ± SEM 25.697, n = 3) and tumor necrosis factor (TNF)-α ( Figure S3c , mean 5.365 ± SEM 4.581, n = 3) compared to coculture with T unstim (IL-6 mean 5.15 ± SEM 4.917, IL-1β mean 7.4 ± SEM 6.521, TNF-α mean 2.263 ± SEM 0.055) ( Figure S3a–c ).

HRQoL data from the ASCEMBL trial comparing asciminib to bosutinib in patients with CML-CP previously treated with ≥2 TKIs showed a trend of improvement in the MDASI-CML and EQ-5D-5L scores in the asciminib arm, including fatigue, whereas there was a worsening of gastrointestinal symptoms in the bosutinib arm.

Again, the group with high p-tau217 and normal PET group did not reach statistical significance but showed a trend towards significant association with DESH, suggesting that these differences may be dictated by plasma biomarker factors more so than amyloid PET elevation, but the variance was also greater in the p-tau217 analyses.

STEC/ETEC hybrids exhibited significantly higher cytotoxicity compared to ETEC mono-pathotypes, and they showed a trend toward increased cytotoxicity compared to STEC isolates.