Barely Significant
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“showed a trend”

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In the literature

In a phase 2 trial of combination glatiramer acetate 20 ​mg SC daily, with either daily oral estriol 8 ​mg or placebo, the primary outcome (ARR at 2 years) showed a trend but was not significant [ 71 ].
Impact of sex on multiple sclerosis therapy.
Neurotherapeutics · 2025 · PMC12418430