Barely Significant
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“showed a trend”

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showed a trendP = .071.4× alpha
Potential confounding factors Although iron deficiency’s potential impact on PROs was not analyzed due to the low prevalence of abnormal hemoglobin levels (4.5% of the cohort), patients receiving iron supplementation ( n = 53) showed a trend toward lower SF-36 mental scores (mean MCS, 42) than untreated patients ( n = 133; mean MCS, 45; P = .07).
showed a trendP=0.071.4× alpha
When these patients were separated out from the rest of the hyperselection MUT group, the remaining cohort who received Pmab showed a trend towards benefit compared to 5FU/LV alone [median PFS (mPFS) 11.6 vs. 5.0 months, HR =0.41; 95% CI: 0.16–1.05, P=0.07], which may suggest benefit from maintenance Pmab in non- BRAF V600E hyperselection MUT cases.
showed a trendp = 0.071.4× alpha
In analyses of baseline metabolite factors with change in pVO 2 between baseline and three months , no factor was significant nominally nor after FDR adjustment for multiple comparisons (Additional file 2 : Table S1), although factor 8 showed a trend for significance (nominal p = 0.07) for baseline levels associated with change in pVO 2 .
showed a trendp = .071.4× alpha
Furthermore, in our post‐mentalizing task, while the total number of items mentalized did not significantly differ between any groups, the ASD group compared to the TD group showed a trend toward overall lower quality of all mentalized responses ( p = .07), and the ASD group had a higher number of poor responses ( p = .05).