Within this, endpoint voxel assessment of GABA+ data was possible in 5/11 simvastatin and 9/15 placebo and showed a trend towards between-group increase in the simvastatin group compared to placebo (mean 1.82 placebo vs. 2.39 simvastatin ( t (12) = − 2.12, p = .055, two-tailed uncorrected), although this was not present when adjusted for baseline values (ANCOVA p = 0.188, Mann-Whitney p = 0.66; Fig. 3 a).
Low-level laser therapy showed a trend toward reduced odds of insomnia (OR = 0.024; 95% CI: 0.0005–1.09; p = 0.055), and iontophoresis demonstrated a non-significant trend (OR = 31.3; 95% CI: 0.81–1200; p = 0.064).
However, mice receiving UK4 showed a trend towards increased freezing behaviour in phase 3—contextual memory ( F (2,34) = 3.181, p = 0.055) (Fig. 2 d).
RAB7A expression showed a trend towards increased expression after the addition of RA following RV infection ( P = 0.055) ( Fig. 4 I).
The presence of cardiovascular disease at baseline assessment showed a trend for worse outcome (HR: 3.101, 95% CI: 0.976–9.854, p = 0.055).
Similar to PFS, histologic grade significantly impacted OS in univariate analysis (p=0.012) and showed a trend in multivariate analysis (p=0.055).
Mean CAV-free survival was 47.5 months (95% CI [43.1–51.8]) ( Figure 1 ). Although the sample was substantively smaller and the follow-up time substantively shorter in the group that did not receive statin therapy ( Table 1 ), treatment with a statin after transplantation showed a trend towards improved CAV-free survival compared with those who did not receive statin therapy (p=0.055).
The diagnosis, number of quadrants of MIT/GATT, or the severity of the damage did not influence the need for medications after either surgery, while the number of superficial venular staining in >2 quadrants showed a trend toward significant association with the need for additional medicines (p = -0.1, p = 0.055).
Quantification of L-2-hydroxyglutarate showed a trend (P = 0.055) to decrease in the OB of the Ndufs4 KO mouse ( Fig. 2 E), whereas α-ketoglutarate concentration was unchanged ( Fig. 2 F).
In contrast, at time point T1, while we found no differences in entries and time spent in the open arms (panel G, two‐tailed Mann–Whitney test, U = 26, p = 0.1970 and panel H, two‐tailed Mann–Whitney test, U = 33, p = 0.5289), finasteride‐treated rats showed a trend toward more entries to the closed arms (Figure 7K , two‐tailed Mann–Whitney test, U = 14, p = 0.055), suggesting a preference to less anxiogenic component of the maze.
Finally, in the multivariate analysis of Global Adaptive Functioning (GAF), Social Problems showed a trend-level negative association (B = −0.71, p = 0.055), consistent with the pattern observed in the univariate model, but not reaching conventional statistical significance ( Table 5 ).
A linear mixed-effect model showed a trend for the group × time interaction towards significance (F(2, 39.82) = 3.13, p = 0.055; see Table 4 B).
DM to bone were associated with worse survival ( p = 0.0257) and patients with pulmonary metastasis showed a trend toward improved survival ( p = 0.055) ( p = 0.12, Figure S1 ).
In addition, group 1 showed a trend reduction in one of the cognitive performance indicators digital symbol test and trail making test compared to group 3 (dg_sym p-value = 0.055 and tmt_A_rt, p-value = 0.078) (Fig. 7d ).
However, the TKD group showed a trend of reduction in sway velocity, particularly during double leg stance under unstable surface with eyes closed condition ( P =0.055; ES=0.8).
Women with pronation showed a trend toward RTL shortening (p=0.055), possibly due to the small sample size. 3.4.
EUS-GE also showed a trend toward shorter time to chemotherapy resumption (17 days vs 24 days, p=0.055) and a higher probability of 6-month stent-free survival (95.5% vs 67.7%, log-rank test, p=0.047).
Those characteristics found to be significant ( p < 0.006 after Bonferroni correction for multiple tests representing an alpha level of 0.05) or showed a trend ( p < 0.055) on univariate analyses were subsequently analyzed in a multivariate manner with the Cox proportional hazards model.
Multiple exposures (23.0%) improved compliance relative to single exposures (14.8%, p = 0.037), and exposure to stray animals showed a trend toward higher adherence ( p = 0.055).
The IPI score ≥ 3 was an independent predictor of inferior PFS (HR 2.11, p = 0.042) and showed a trend toward worse OS (HR 2.64, p = 0.055) in multivariate analysis, reinforcing its established role in identifying high-risk patients, including those aged ≥ 80 years, as supported by prior studies [ 16 , 28 ].
STAR showed a trend toward a superior discrimination for mortality than GOLD (AUC 0.63 [95%CI 0.55–0.71] vs. 0.55 [0.47–0.63]; p = 0.055), although BODEx remained the most accurate predictor (AUC = 0.70 [0.63–0.77]).
These showed a trend-level reduction in NAA in AnxDs ( g = −0.47, 95% CI = +0.01 to −0.95, p = 0.055).
Median LAWT showed a trend towards being lower in female than in male subjects that did not reach statistical significance in univariate analysis (1.22 mm v 1.31 mm, p = 0.055).
Compared with upfront surgery, neoadjuvant therapy showed a trend towards prolonged PFS in matched groups (p=0.055), but not in OS (p=0.81).
In our study, preoperative smoking showed a trend toward association with postoperative hypoxemia ( P = .055), although it did not reach conventional statistical significance.