“nominally significant”

The analysis, focusing on nominally significant hits ( p < 0.05, >1.5-liner fold change) and the Reactome and KEGG pathway databases [via WebGestalt ( Subramanian et al., 2005 ; Liao et al., 2019 )], failed to detect FDR significant enrichment.

The expression of five of these 64 genes ( HLA-DQA1 , INPP5D , SPDYE3 , TSPOAP1 , and SIGLEC11 ) were nominally significant ( P < 0.05) in the analysis of the combined blood and brain data (Table 2 , Supplemental Table 4 , Supplementary Fig. 2 ).

At one of the 13 CpGs reported by Kallak et al., we found nominally significant ( p < 0.05) differential DNAme associated with SSRI exposure status in the placenta in the same direction as the original cord blood association: higher DNAme in SSRI-exposed cases.

Similarly, urinary DAP metabolite concentrations, including DEP, DETP, DMDTP and DEDTP, showed nominally significant associations ( p < 0.05) with at least one of these two outcomes.

Patients receiving etanercept monotherapy had less deterioration of PtGA and PtJP scores versus those assigned to methotrexate monotherapy, with a nominally significant treatment difference observed at almost all time points for PtGA and PtJP at weeks 12 and 36 ( p < 0.05; Fig. 1 ).

The MR‐Egger test showed a nominally significant causal effect ( P <0.05) of CHD on a lower level of mtDNA CN (β=−0.030 [95% CI, −0.055 to −0.0045]; P =0.029) (Table S7 ).

This effect was nominally significant (p < 0.05) for four of the eight fingers tested: left 2 nd finger, left 5 th finger, right 2 nd finger, and right 4 th finger ( Table 2 ).

We identified 74 nominally significant differentially methylated regions ( p < 0.05) in the mitochondrial genome, between anatomically separate cortical regions and the cerebellum in matched samples ( N = 3 matched donors).

In total, we found 227 nominally significant ( P < 0.05) differentially expressed genes (DEGs) between the treated and control groups, with 23 DEGs significant after adjustment for multiple correction ( Fig. 2c , Table S2).

CSF and plasma levels of AMD and CSF levels of cystatin M showed nominally significant associations ( P < 0.05) with microbleeds in plasma ( Supplementary Table 6 ), in the same direction as significant associations with WMHs and WM-PVSs, respectively.

2a ), and 53 showed nominally significant associations in the CKDGen cohorts alone ( p < 0.05; Supplementary Data 4 ).

Results were considered nominally significant at p < 0.05 (two-tailed).

Transcriptional differences between subject groups (i) Discovery Cohort ANOVA revealed 11 genes which showed nominally significant transcriptional differences (p≤0.05) between our three subject groups.

We performed the association analyses with FG, FI, HOMA-B, HOMA-IR and BMI SDS for the 42 variants, assuming an additive genetic model implemented in linear regression and detected nominally significant associations ( P < 0.05) at eight FG, eight T2D and two FI loci with the phenotypes tested (Material and Methods, Supplementary Material, Table S1 ).

The majority of the hypomethylated (20/28) sites showed lower M-values in the SWD group as compared with the controls; accordingly, the majority (9/10) of the hypermethylated showed higher M-values in SWD (one site, cg13823003 from GRIN2C , with a nominally significant difference at P < 0.05, analysis of variance (ANOVA) (Supplementary Table S6 ).

After Bonferroni correction, the rs1800450 exonic polymorphism in MBL2 demonstrated statistically significant association with TBI outcome ( p = 5·24 × 10 −4 ), followed by three nominally significant ( p < 0·05, uncorrected) associations (rs1800629 in TNF ; rs5030737 and rs7096206 in MBL2 ) (Supplementary Table 5).

A 2‐sided P <0.05 was regarded as nominally significant, and a BH‐adjusted P <0.05 was considered statistically significant.

Seven of the 10 polymorphisms showed nominally significant signals of association with MS (p<0.05) ( table 1 ).

In total, 7/34 CpGs identified in the discovery cohort were nominally significant ( P < 0.05 and same direction of effect as the ARIC cohort results) (Additional file 4 : Table S3), and the effect sizes from the ARIC results and the validation meta-analysis were largely correlated ( R 2 = 0.36) (Fig. 2 ).

In the left hemisphere, nominally significant differences (uncorrected p < 0.05) were observed in three parcels: lingual gyrus ( p = 0.033), inferior temporal gyrus ( p = 0.041), and precuneus ( p = 0.048).

Other gene/environment interaction associations with individual symptom domains were nominally significant ( p < 0.05), although given the small sample size and lack of power, many are likely to be false positive signals or a result of correlation among the symptoms themselves.

Among these, all genes met FDR <0.05 in Group 1, 563 of 585 in Group 2, and none in the lineage-balanced Group 3, though all remained nominally significant ( p < 0.05).

The meaningful and nominally significant thresholds were set at p < 0.05/138 = 0.0004 and p < 0.05, respectively, out of 138 tests conducted.

While the 19 exome-wide significant genes were not significantly associated (all p > 4.38 × 10 −4 , Bonferroni adjustment for 19 unique genes × 6 phenotypes) with any other tissue-specific fat components, we observed that nominally significant associations ( p < 0.05) generally shared the expected direction of effect on the primary and supplemental phenotypes ( Figures 2 and S3 ).

5 A), while Hannum’s IEAA, Zhang’s EEAA, and raw epiTOC were only nominally significant ( p value < 0.05).