“nominally significant”

As a result, between 16 and 66 pathways between the three contrasts were rendered nominally significant ( p < 0.05).

Seven of the 10 polymorphisms showed nominally significant signals of association with MS (p<0.05) ( table 1 ).

In total, 7/34 CpGs identified in the discovery cohort were nominally significant ( P < 0.05 and same direction of effect as the ARIC cohort results) (Additional file 4 : Table S3), and the effect sizes from the ARIC results and the validation meta-analysis were largely correlated ( R 2 = 0.36) (Fig. 2 ).

Other gene/environment interaction associations with individual symptom domains were nominally significant ( p < 0.05), although given the small sample size and lack of power, many are likely to be false positive signals or a result of correlation among the symptoms themselves.

While the 19 exome-wide significant genes were not significantly associated (all p > 4.38 × 10 −4 , Bonferroni adjustment for 19 unique genes × 6 phenotypes) with any other tissue-specific fat components, we observed that nominally significant associations ( p < 0.05) generally shared the expected direction of effect on the primary and supplemental phenotypes ( Figures 2 and S3 ).

Differentially methylation CpG sites The epigenome-wide differential methylation analysis revealed 26982 CpG sites that differed between obese and lean individuals with nominally significant p-values (p ≤ 0.05).

Those genes that yielded at least nominally significant interaction terms (raw p < 0.05 ) and FDR-significant associations within male or female strata were determined to have sex-specific associations with Cd.

Among these, all genes met FDR <0.05 in Group 1, 563 of 585 in Group 2, and none in the lineage-balanced Group 3, though all remained nominally significant ( p < 0.05).

as potential biomarkers, two were not identified in our study, one (Hemoglobin subunit β) was found to be nominally significant ( p < 0.05) but did not pass adjustment for multiple testing, and the remaining five were identified but not found to be significant in our study.

Many of our networks had nominally significant (p < 0.05) overlaps with the cell-type-specific DEGs in neuronal cell types, which include both upper and deep layer excitatory neurons and inhibitory interneurons ( Figure 3 C and Table S12 ).

In a combined meta-analysis, we could identify a nominally significant association between rs4746720 and proteinuria, and between 4 SNPs, rs2236319, rs10823108, rs3818292, rs4746720, and combined phenotypes (proteinuria + ESRD, P < 0.05).

5 A), while Hannum’s IEAA, Zhang’s EEAA, and raw epiTOC were only nominally significant ( p value < 0.05).

The meaningful and nominally significant thresholds were set at p < 0.05/138 = 0.0004 and p < 0.05, respectively, out of 138 tests conducted.

CSF and plasma levels of AMD and CSF levels of cystatin M showed nominally significant associations ( P < 0.05) with microbleeds in plasma ( Supplementary Table 6 ), in the same direction as significant associations with WMHs and WM-PVSs, respectively.

Out of 14 shared knowns that had genome-wide significant associations in OE, 7 had nominally significant ( p < 0.05) and directionally consistent associations in MCDS.

Patients receiving etanercept monotherapy had less deterioration of PtGA and PtJP scores versus those assigned to methotrexate monotherapy, with a nominally significant treatment difference observed at almost all time points for PtGA and PtJP at weeks 12 and 36 ( p < 0.05; Fig. 1 ).

In total, we found 227 nominally significant ( P < 0.05) differentially expressed genes (DEGs) between the treated and control groups, with 23 DEGs significant after adjustment for multiple correction ( Fig. 2c , Table S2).

The MR-Egger (SIMEX) method yielded nominally significant ( P < 0.05) causal effects ( P = 0.032).

Although the association between rs4916251 and AAA was only nominally significant ( P < 0.05) in one of the cohorts tested (the AC), it is important to note that the AC was the largest study with the greatest statistical power, and that the meta-analysis estimate showed little evidence of heterogeneity ( I 2 = 13%).

Searches for clustering of SNPs with nominally-significant case vs control differences in each European-American sample We identified 3125 clusters of SNPs that displayed nominally significant, p<0.05 case vs control differences for χ 2 results from dbGAP samples and 2931 clusters with nominally significant t test results from NIDA/MNB samples.

We considered as conservative joint criteria for confirmed association: 1) identification of the same high-risk allele in the GWA study and both of the replication studies; 2) nominally significant ( P < 0.05) association in both replication cohorts or significant association in one and marginal association in the other replication cohort; 3) significant (Bonferroni uncorrected P < 1.0 × 10 -2 ; 0.05 / 5) combined replication stage 1 + 2 P value; and 4) a genome-wide significant ( P < 5 × 10 -8 ) ( ref. 7 ) overall combined P value.

Interestingly, SCZ showed a nominally significant proportion of caQTL-mediated heritability in LCLs (p<0.05, MESC), consistent with the hypothesis that B cells may play some role in SCZ pathogenesis ( Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014 ; van Mierlo et al., 2019 ).

We discovered 87 nominally significant genes with differing ASE between IRF1 conditions (Fisher’s exact test p < 0.05).

To explore the utility of this concept in interpreting our KGD data, we mapped the nominally significant KGDs (p ≤ 0.05) identified for each cancer driver gene across all histotypes onto the high-confidence STRING functional interaction network ( Franceschini et al., 2013 ) (see Experimental Procedures ).

In mediation analyses, nine metabolites and five plasma proteins showed nominally significant mediation effects in the SGLT2–DR pathway (uncorrected P < 0.05; Supplementary Table S16 ).