“nominally significant”

Finally, to characterize the functional relevance of genes driving the association between effects of LPS on MR imaging measures and expression of cell-type specific genes, we ran a Gene Ontology analysis using genes that were: (i) nominally significant p < 0.05 (MR imaging measure vs. gene expression correlation), and (ii) within the 10th decile in cell specificity for a given cell type (IT4/5 excitatory, or Parvalbumin inhibitory).

The rs1046322 and rs9457 polymorphisms showed nominally significant ( p < 0.05) association in all three (type 1, type 2 and combined) analyses, which remained significant in all cases after FDR correction for multiple testing.

The mediating effects of three body fat indexes ( BMI, WHR and body fat percentage ), which were nominally significant in both models ( P < 0.05), were further evaluated for nature indirect effects ( NIE ) and nature direct effects ( NDE ) on the impact of age on diabetes oncome by VanderWeele's mediation approach 25 , 26 , 27 as follows: M B o d y _ f a t _ i n d e x e s = β 0 + β A g e ⋅ A g e + B ⋅ C o v a r i a

In total, we found 227 nominally significant ( P < 0.05) differentially expressed genes (DEGs) between the treated and control groups, with 23 DEGs significant after adjustment for multiple correction ( Fig. 2c , Table S2).

In the left hemisphere, nominally significant differences (uncorrected p < 0.05) were observed in three parcels: lingual gyrus ( p = 0.033), inferior temporal gyrus ( p = 0.041), and precuneus ( p = 0.048).

Results From the 52 CpGs identified in blood and selected for replication, 15 CpGs showed nominally significant associations with type 2 diabetes in the Lifelines sample ( p < 0.05).

Patients receiving etanercept monotherapy had less deterioration of PtGA and PtJP scores versus those assigned to methotrexate monotherapy, with a nominally significant treatment difference observed at almost all time points for PtGA and PtJP at weeks 12 and 36 ( p < 0.05; Fig. 1 ).

Of the 245 UKB associations (226 previously reported + 19 previously unreported associations), we find that 72% (176) show at least nominally significant ( p < 0.05 ) age-specific effects within UK women ( Figure 2 C). 37 of these 176 associations, representing 15% of all associations, have a slope with a genome-wide significant p value ( p < 5 × 10 − 8 ), constituting a more stringent criterion (strong and moderate evidence in Figure 2C).

This concordance persisted at the final infusion visit (Spearman’s ρ : 0.46, q < 0.05), with additional nominally significant concordance (p < 0.05, q > 0.05) for CDCA (Spearman’s ρ : 0.27) and HCA (Spearman’s ρ : 0.26) at that visit.

We identified 74 nominally significant differentially methylated regions ( p < 0.05) in the mitochondrial genome, between anatomically separate cortical regions and the cerebellum in matched samples ( N = 3 matched donors).

The MR‐Egger test showed a nominally significant causal effect ( P <0.05) of CHD on a lower level of mtDNA CN (β=−0.030 [95% CI, −0.055 to −0.0045]; P =0.029) (Table S7 ).

Results were considered nominally significant at p < 0.05 (two-tailed).

CSF and plasma levels of AMD and CSF levels of cystatin M showed nominally significant associations ( P < 0.05) with microbleeds in plasma ( Supplementary Table 6 ), in the same direction as significant associations with WMHs and WM-PVSs, respectively.

The majority of the hypomethylated (20/28) sites showed lower M-values in the SWD group as compared with the controls; accordingly, the majority (9/10) of the hypermethylated showed higher M-values in SWD (one site, cg13823003 from GRIN2C , with a nominally significant difference at P < 0.05, analysis of variance (ANOVA) (Supplementary Table S6 ).

A 2‐sided P <0.05 was regarded as nominally significant, and a BH‐adjusted P <0.05 was considered statistically significant.

Of the 75 SNPs found in whites, 34 (46%) were nominally significant at P < 0.05 in Japanese, with 18 at P < 0.0005.

A score of + 1 was assigned if the protein showed positive and nominally significant ( p < 0.05) association with the disease, and +2 if the association was significant after multiple test correction ( FDR-adjusted p < 0.05).

We repeated the analysis using both prevalent type 2 diabetes at baseline and incident type 2 diabetes during follow-up. We estimated the power that our study had to observe a nominally significant association ( p < 0.05) of each individual SNP or the genetic predisposition score with type 2 diabetes, based on the expected effect size (and its SE) of each individual SNP or the score on type 2 diabetes.

Of these, five showed nominally significant ( p < 0.05) association with MS ( Figure 1 , Table 2 ).

Of the 763 transcripts demonstrating nominally significant (p < 0.05) correlation with total serum IgE, 652 (85%) map to a unique HUGO gene id and were used for IPA canonical pathway analysis.

Of the 512, 142 (27.7%) had been tested by the IMPC and 64 (12.5% of the 512 prioritized genes, 45% of the 142 IMPC-tested genes) had a nominally significant (p ≤ 0.05) alteration of whole-body BMD in knockout/knockdown mice, compared to controls.

After mapping these CpG sites to genes, performing GO enrichment analyses, and removing overlapping GO terms, there were a total 95, 76, and 47 nominally significant (hypergeometric test P < 0.05) biological processes, respectively.

Other gene/environment interaction associations with individual symptom domains were nominally significant ( p < 0.05), although given the small sample size and lack of power, many are likely to be false positive signals or a result of correlation among the symptoms themselves.

While the 19 exome-wide significant genes were not significantly associated (all p > 4.38 × 10 −4 , Bonferroni adjustment for 19 unique genes × 6 phenotypes) with any other tissue-specific fat components, we observed that nominally significant associations ( p < 0.05) generally shared the expected direction of effect on the primary and supplemental phenotypes ( Figures 2 and S3 ).

The meaningful and nominally significant thresholds were set at p < 0.05/138 = 0.0004 and p < 0.05, respectively, out of 138 tests conducted.