“nominally significant”

We selectively included 44 diseases (excluding cancer, which is a limitation to be noted) in the first part of phenome-wide association analysis (PheWAS) and identified nominally significant associations ( P < 0.05) between the SES-associated variants and CHD.

Fisher-Irwin exact tests of association determine the best possible mode of genetic effect at a nominally significant p-value < 0.05.

They first extracted nominally significant signals ( p <0.05) from three GWAS studies (WTCCC, German, and NIMH GAIN datasets; Fangerau et al., 2004 ; Wellcome Trust Case Control Consortium, 2007 ; Baum et al., 2008 ), and prioritized potential candidates based on independent, converging lines of evidence from various bioinformatics resources.

We found nominally significant ( P <0.05) evidence of association for 22 variants (6 IBD, 10 CD, and 6 UC; Table 2 ).

Nominally significant associations (p<0.05) were retested assuming a dominant and a recessive model in the same way as described above.

In the replication, the pooled analysis for the correlation between LysoPC-acyl C16:0 and BAT activity was nominally significant (p < 0.05), but fell slightly short of reaching statistical significance after Bonferroni correction (p = 0.01) (Table 2 ; Fig. 3 d).

From the GO based analysis, 465 nominally significant ( p < 0.05) terms were identified as enriched within the 374 genes ( Supplementary Table 2 ).

The differences in allele and genotype frequencies between ALL cases and controls were nominally significant (P < 0.05) for 20 SNPs.

For associations with infections, we visualized the results of all allelic associations which had at least nominally significant p-values (P ≤ 0.05) with at least one infection category or with the “any infection” phenotype.

Here, we restricted the GRSs to index variants from the previous study 21 that were not only GWAS significant for at least one trait, but also nominally significant ( p -value < 0.05) for the remaining traits.

It is essential to note that all reported P values are merely nominally significant ( P < .05), but none remained statistically significant after Bonferroni correction.

Proteins significantly associated with hippocampal volume and WMHs Using partial Spearman correlation, we found nominally significant associations ( P < .05) between 377 proteins and hippocampal volume in all individuals.

We repeated the analysis using both prevalent type 2 diabetes at baseline and incident type 2 diabetes during follow-up. We estimated the power that our study had to observe a nominally significant association ( p < 0.05) of each individual SNP or the genetic predisposition score with type 2 diabetes, based on the expected effect size (and its SE) of each individual SNP or the score on type 2 diabetes.

Of the 245 UKB associations (226 previously reported + 19 previously unreported associations), we find that 72% (176) show at least nominally significant ( p < 0.05 ) age-specific effects within UK women ( Figure 2 C). 37 of these 176 associations, representing 15% of all associations, have a slope with a genome-wide significant p value ( p < 5 × 10 − 8 ), constituting a more stringent criterion (strong and moderate evidence in Figure 2C).

The resulting p -values were considered nominally significant at p < 0.05.

The rs1046322 and rs9457 polymorphisms showed nominally significant ( p < 0.05) association in all three (type 1, type 2 and combined) analyses, which remained significant in all cases after FDR correction for multiple testing.

AG), and there was a nominally significant difference between the two groups with respect to log-additive model ( P < 0.05, Table 3 ).

In the left hemisphere, nominally significant differences (uncorrected p < 0.05) were observed in three parcels: lingual gyrus ( p = 0.033), inferior temporal gyrus ( p = 0.041), and precuneus ( p = 0.048).

If the multiplicative interaction between a SNP and well-water As was nominally significant ( p < 0.05), we also tested the corresponding multiplicative interaction between the SNP and baseline urinary creatinine-adjusted As for the same outcome.

Almost all these genes showed a tendency towards downregulation at T3, and 9 of them exhibited a nominally significant decrease of expression after surgery (P<0.05).

In total, we found 227 nominally significant ( P < 0.05) differentially expressed genes (DEGs) between the treated and control groups, with 23 DEGs significant after adjustment for multiple correction ( Fig. 2c , Table S2).

Ontology analyses We found 8238 CpG sites that were associated with abuse (adjusting for neglect) with uncorrected, nominally significant p values < 0.05.

Patients receiving etanercept monotherapy had less deterioration of PtGA and PtJP scores versus those assigned to methotrexate monotherapy, with a nominally significant treatment difference observed at almost all time points for PtGA and PtJP at weeks 12 and 36 ( p < 0.05; Fig. 1 ).

Finally, to characterize the functional relevance of genes driving the association between effects of LPS on MR imaging measures and expression of cell-type specific genes, we ran a Gene Ontology analysis using genes that were: (i) nominally significant p < 0.05 (MR imaging measure vs. gene expression correlation), and (ii) within the 10th decile in cell specificity for a given cell type (IT4/5 excitatory, or Parvalbumin inhibitory).

In the EA meta-analysis of SNP-by-anger interactions for the C10orf107 region, no single SNPs were measured in at least two cohorts and had at least a nominally significant p -value for the interaction with anger ( p < 0.05).