“nominally significant”

Out of 14 shared knowns that had genome-wide significant associations in OE, 7 had nominally significant ( p < 0.05) and directionally consistent associations in MCDS.

In the EA meta-analysis of SNP-by-anger interactions for the C10orf107 region, no single SNPs were measured in at least two cohorts and had at least a nominally significant p -value for the interaction with anger ( p < 0.05).

Here, we restricted the GRSs to index variants from the previous study 21 that were not only GWAS significant for at least one trait, but also nominally significant ( p -value < 0.05) for the remaining traits.

Proteins significantly associated with hippocampal volume and WMHs Using partial Spearman correlation, we found nominally significant associations ( P < .05) between 377 proteins and hippocampal volume in all individuals.

In addition, nominally significant differences (ie, P < 0.05) between groups were obtained in secondary analyses comparing the treatment groups with respect to measures of pain interference with function and sleep using items from the BPI interference question.

For associations with infections, we visualized the results of all allelic associations which had at least nominally significant p-values (P ≤ 0.05) with at least one infection category or with the “any infection” phenotype.

AG), and there was a nominally significant difference between the two groups with respect to log-additive model ( P < 0.05, Table 3 ).

After multiple testing corrections, one of these SNPs was significant (rs73349121, p = 0.0001), 9 were nominally significant ( p < 0.05, with 5 expected), and 58/99 had a direction of effect that was consistent with the Whites-only analyses (one-sided p = 0.04, Fig. 2 ).

We repeated the analysis using both prevalent type 2 diabetes at baseline and incident type 2 diabetes during follow-up. We estimated the power that our study had to observe a nominally significant association ( p < 0.05) of each individual SNP or the genetic predisposition score with type 2 diabetes, based on the expected effect size (and its SE) of each individual SNP or the score on type 2 diabetes.

The 11bp indel in ASIP known to cause the black base coat colour was not significant ( P >0.05); however, six single nucleotide polymorphisms (SNPs) within the genomic region encoding the ASIP gene and one within MC1R were identified as being nominally significant ( P <0.05) in association with opioid analgesic effectiveness.

These four associations were only nominally significant ( α < p < 0.05) but also ranked at the top four in females (Table 1 ).

Discussion In a population with chronic mental illness, various SNPs in 10 candidate genes ( PPP1R1B , BDNF , DRD3 , DRD2 , HTR2A , HTR2C , COMT , MnSOD , CYP1A2 , and RGS2 ) reached nominally significant (p≤0.05) associations with drug-induced movement disorder.

Out of the 36 SNPs examined, 13 SNPs were found to be nominally significant (unadjusted p -value < 0.05) with individual items ( Table 4 ). 3.5.

A nominally significant association (10 –5 < p ≤ 0.05) was observed for only 8 of the 249 markers (~ 3%).

Comparison of miRNA profiles between low- and high-risk tumors identified multiple candidate miRNAs with nominally significant differential expression ( p < 0.05).

Of the 245 UKB associations (226 previously reported + 19 previously unreported associations), we find that 72% (176) show at least nominally significant ( p < 0.05 ) age-specific effects within UK women ( Figure 2 C). 37 of these 176 associations, representing 15% of all associations, have a slope with a genome-wide significant p value ( p < 5 × 10 − 8 ), constituting a more stringent criterion (strong and moderate evidence in Figure 2C).

Fisher-Irwin exact tests of association determine the best possible mode of genetic effect at a nominally significant p-value < 0.05.

Additionally, for each of the 594 eGFR signals, we queried further genetic association data relevant to the kidney researcher: (7) To highlight the relevance of a genetic association with creatinine-based eGFR for kidney function rather than creatinine metabolism, we included information on whether the locus association was directionally consistent and nominally significant for blood urea nitrogen (BUN) or cystatin-based eGFR (eGFRcys; i.e. locus lead variant P < 0.05; opposite or same direction of effect for BUN or eGFRcys, respectively; n = 852,678 or 460,826, respectively; yielding 491 of 594 signals validated); (8) Since genetic effects with steeper decline versus more stable eGFR over time might point to particularly deleterious mechanisms for the kidney, we included information on whether the signal showed significant association on eGFR decline (N = 343,339 [ 25 ], yielding 8 decline signals).

However, 8 factors were nominally significant ( p <0.05): city, age, obesity, physical appearance, parenting style, studying communication skills with children, confidence, and working hours.

Patients receiving etanercept monotherapy had less deterioration of PtGA and PtJP scores versus those assigned to methotrexate monotherapy, with a nominally significant treatment difference observed at almost all time points for PtGA and PtJP at weeks 12 and 36 ( p < 0.05; Fig. 1 ).

Association of genetically-predicted height with clinical traits A total of 142 traits were associated with genetically-predicted height at phenome-wide significance among EA individuals, 2 of which were phenome-wide significant in AA individuals as well, and another 46 of which were nominally significant ( p < 0.05) in AA individuals ( Fig 1B and S3 and S4 Tables ).

In total, we found 227 nominally significant ( P < 0.05) differentially expressed genes (DEGs) between the treated and control groups, with 23 DEGs significant after adjustment for multiple correction ( Fig. 2c , Table S2).

The MR‐Egger test showed a nominally significant causal effect ( P <0.05) of CHD on a lower level of mtDNA CN (β=−0.030 [95% CI, −0.055 to −0.0045]; P =0.029) (Table S7 ).

In the left hemisphere, nominally significant differences (uncorrected p < 0.05) were observed in three parcels: lingual gyrus ( p = 0.033), inferior temporal gyrus ( p = 0.041), and precuneus ( p = 0.048).

Additionally, nominally significant ( P <0.05) suggestive associations with greater odds of staying at the Care Hotel were noted for younger age [OR (per 10-year increase)=0.90, P =0.035], lower Charlson comorbidity index [OR (per 1 unit increase)=0.95, P =0.032], and longer distance travelled to the hospital [OR (per each doubling)=1.09, P =0.010].