“nominally significant”

Within KEGG, the acRPB1 enriched genes had nominally significant overlap (uncorrected p < 0.05) with genes involved in several developmental signaling pathways, focal adhesion, and actin cytoskeleton regulation (Additional file 5 ).

We performed over-/under-representation analysis of GO themes in the genes where the RBP plus model was nominally significant (p < 0.05), using uncorrected p-values for GO analysis to reduce the false negative rate of a stricter FDR-based threshold.

S5) and nominally significant GO terms (p-value < 0.05) were grouped according to their semantic similarity to reduce redundancy, enabling a clearer description of the biological processes in which the genes of each module were involved (Supplementary Tab.

Differentially expressed genes (DEGs) at the transcriptome‐wide significance (TWS) level (P<10 ‐6 ) in meta‐analysis and nominally significant (P<0.05) in at least two datasets were included in subsequent analyses of pathways and associations with cognitive and neuropathological traits.

Polygenic scores for behavioural traits None of the associations between PGSs for behavioural traits and SUD-related phenotypes surpassed multiple testing corrections, however, nominally significant associations ( p < 0.05) are detailed bellow.

However, 12 out of 245 CpG sites showed nominally significant differences ( p < .05) between pre‐ and post‐menopausal women.

Out of 14 shared knowns that had genome-wide significant associations in OE, 7 had nominally significant ( p < 0.05) and directionally consistent associations in MCDS.

If such interaction was nominally significant ( P < 0.05), the analysis was conducted separately in cases and control subjects (eg, after stratifying by asthma).

In unadjusted analyses, 26 SNPs from nine loci were associated with TC, 22 SNPs from 10 loci with LDL, 58 SNPs from 13 loci with HDL, and 40 SNPs from 14 loci with logTG at the nominally significant level ( P < 0.05).

We retained for downstream analyses all loci with nominally significant binomial p values ( p < 0.05) and at least 2 reads (10%) mapped to any allele.

They first extracted nominally significant signals ( p <0.05) from three GWAS studies (WTCCC, German, and NIMH GAIN datasets; Fangerau et al., 2004 ; Wellcome Trust Case Control Consortium, 2007 ; Baum et al., 2008 ), and prioritized potential candidates based on independent, converging lines of evidence from various bioinformatics resources.

Results Nominally significant evidence for association (p < 0.05) was found for seven markers (D5S0023i, IL9, RH60252, 5Q3133_33, D5S2017, D5S1481, D5S0711i) which were then individually genotyped in the trios.

Fisher-Irwin exact tests of association determine the best possible mode of genetic effect at a nominally significant p-value < 0.05.

Of these, five showed nominally significant ( p < 0.05) association with MS ( Figure 1 , Table 2 ).

The 36 nominally significant miRNAs ( p < 0.05) identified in the PDN/PDD comparison from LIMMA were used to classify disease state (See Figure 2B ), though with more limited accuracy than the PD-control model (absolute error rate = 13.8%, sensitivity = 81.2%, specificity = 88.9%).

Using these phenotypes, we computed the odds ratio of the proportion of nominally significant ( p < 0.05) hits in the EPAS1 gene region (chr2:46,150,000–46,450,000) encompassing our regulatory elements compared with variants in a randomly selected matched window.

Finally, we also observed a nominally significant ( P value < 0.05) and directionally consistent indirect effect for rs4765127 ( ZNF664 ) on TG4through a nearby CpG (cg02647265), which lies 4 kb upstream of our tag SNP in the 5′UTR (untranslated region) of CCDC92 , the gene adjacent to ZNF664 .

The global analysis revealed only a modest transcriptomic signal associated with suicide, with ten nominally significant DEGs identified at the predefined threshold ( p < 0.05 and |logFC| > 0.15), although none remained significant after FDR correction ( CKS2 , PDE2A , TYROBP , H2BC12 , TMED1 , EPCAM , ADORA3 , EGR3 , NR4A2 , and NEUROD6 ).

Psychometric Architecture of Cognitive Constructs: Principal Components Analysis Twenty cognitive subtests with nominally significant ( P < .05) baseline group differences were selected for PCA.

The genes in each cluster showed nominally significant enrichment ( P < 0.05, but FDR > 0.05).

As shown in Table 1 , results of the Gene ontology term enrichment analysis revealed 14 nominally significant (uncorrected p <0 .05) associations, but only the mitochondrion GO:0005739 (Benjamini Hochberg p adj = 0.002) survived correction for multiple testing.

AG), and there was a nominally significant difference between the two groups with respect to log-additive model ( P < 0.05, Table 3 ).

Here, we restricted the GRSs to index variants from the previous study 21 that were not only GWAS significant for at least one trait, but also nominally significant ( p -value < 0.05) for the remaining traits.

We selectively included 44 diseases (excluding cancer, which is a limitation to be noted) in the first part of phenome-wide association analysis (PheWAS) and identified nominally significant associations ( P < 0.05) between the SES-associated variants and CHD.

We repeated the analysis using both prevalent type 2 diabetes at baseline and incident type 2 diabetes during follow-up. We estimated the power that our study had to observe a nominally significant association ( p < 0.05) of each individual SNP or the genetic predisposition score with type 2 diabetes, based on the expected effect size (and its SE) of each individual SNP or the score on type 2 diabetes.