“nominally significant”

A total of 205 risk factor associations were found to be nominally significant ( p < 0.05).

RESULTS: Six BMI loci ( TMEM18, NUDT3/HMGA1, FAIM2, FTO, MC4R and KCTD15 ) and two WC/WHR loci ( VEGFA and ITPR2-SSPN ) were nominally significant (P< 0.05) at the index or proxy SNP in the corresponding BMI and WC/WHR models.

In addition, six of the 10 most significantly associated genes are known EE genes, and the majority of the known EE genes (17 out of 25) originally implicated in trio sequencing are nominally significant (p<0.05), a proportion significantly higher than the expected (Fisher’s exact p = 2.33×10 −17 ).

In contrast, just one scale showed a nominally significant ( p < 0.05 uncorrected) greater proportion of individuals with severely elevated scores in XXY/KS as compared to XYY: emotional problems on the SDQ.

One of these haplotypes was nominally significant in the replication cohort ( P < 0.05) and was located in 6q21, a region which has been previously associated with bipolar disorder, a psychiatric disorder that is phenotypically and genetically correlated with MDD.

For any medication with a nominally significant association ( p < .05), the same analysis was repeated in the chemotherapy group to test for nonspecific effects.

Raw P < 0.05 was considered nominally significant, whereas FDR-adjusted P < 0.05 was considered significant after correction for multiple comparisons.

In SMR analyses of gene expression and migraine within the Finnish cohort, six genes—EP300, HDAC3, SIRT1, AARS2, SLC16A1, and SMARCA4—showed nominally significant associations ( P < 0.05).

We evaluated how well independent pQTLs reported by the INTERVAL study 9 ( n = 3301) replicated in our results and found 75.6% to be both directionally consistent and nominally significant ( P < 0.05) (Supplementary Note 2 and Supplementary Figs. 6 and 7 ).

In the overall set of 44 twins, we replicated 184 a-DMRs (38%) with the same direction of effect at a nominally significant threshold (P = 0.05).

Five SNPs showed evidence for nominally significant ( P < 0.05) association with the same direction of effect as the discovery cohort, compared with 1.35 under the null expectation (binomial test P = 0.01; Supplementary Table 4 ). rs143384 reached genome-wide significance in the replication dataset alone (effect allele A, EAF 0.61, OR [95% CI] 1.37 [1.24–1.51], P = 1.33 × 10 −10 ).

A total of 19 HLA alleles had nominally significant maternal and/or fetal effects on BW ( P <0.05; Supplementary Table S7 , available as Supplementary data at IJE online); 13 of the 19 alleles had evidence for a maternal effect only, four alleles primarily had evidence for a fetal effect only and two alleles had evidence of both.

We detected 34 nominally significant differentially methylated regions (DMRs) ( p < 0.05, methylation difference > 10%), that included both hyper- and hypo-methylated loci ( Supplementary File S5 ) ( Figure 9 A).

However, examining the expression of genes linked to p53 P loops (that is, genes linked to loops with one of their anchors at the gene’s promoter and the other at a Nutlin-3a induced p53 binding site) did show modest and nominally significant ( P < .05) induction upon Nutlin-3a treatment in seven of the eight cell lines with functional p53 ( Supplementary Fig.

We detected two variants, MAD1L1 NM_001013836.2 :c.1947C>G p.(Tyr649Ter) and USP45 NM_001346022.3 :c.2190C>A p.(Tyr730Ter), with a higher frequency in the patients than in the controls on a nominally significant level (P < 0.05) (Table 1 ); however, another pLoF in the USP45 gene, NM_001346022.3 :c.1008del p.(Val337SerfsTer9), was found only slightly more often in the patients than in the controls.

We considered that either condition was nominally significant if the confidence interval of the average causal mediated effect did not intersect zero, and had an associated P < 0.05 ÷ 2 (correcting for the two conditions).

A subset of 80/233 (34.3%) FDR significant associations also were nominally significant in at least one population of non-European ancestry ( p value <0.05; Supplementary Data 13 , 14 ).

With a focus on those metabolites that were nominally significant ( p < 0.05) in both populations, we visualized the age by metabolite interactions by plotting the predicted relationship between BDR and age at the 25th, 50th and 75th percentile level of the relevant metabolite.

Three further SNP‘s showed nominally significant interactions ( p < 0.05).

We selectively included 44 diseases (excluding cancer, which is a limitation to be noted) in the first part of phenome-wide association analysis (PheWAS) and identified nominally significant associations ( P < 0.05) between the SES-associated variants and CHD.

Of these, five showed nominally significant ( p < 0.05) association with MS ( Figure 1 , Table 2 ).

Out of 14 shared knowns that had genome-wide significant associations in OE, 7 had nominally significant ( p < 0.05) and directionally consistent associations in MCDS.

We retained for downstream analyses all loci with nominally significant binomial p values ( p < 0.05) and at least 2 reads (10%) mapped to any allele.

They first extracted nominally significant signals ( p <0.05) from three GWAS studies (WTCCC, German, and NIMH GAIN datasets; Fangerau et al., 2004 ; Wellcome Trust Case Control Consortium, 2007 ; Baum et al., 2008 ), and prioritized potential candidates based on independent, converging lines of evidence from various bioinformatics resources.

Fisher-Irwin exact tests of association determine the best possible mode of genetic effect at a nominally significant p-value < 0.05.