“nominally significant”

And, nominally significant results were defined as p < 0.05.

Six of the 23 clinical symptom categories showed nominally significant differences between the carrier and control groups ( p < 0.05, chi-squared test).

In assessing transmission distortion of individual SNPs among these 10 FGF/FGFR genes , two separate markers in FGF19 exhibited nominally significant evidence of linkage and association ( P < 0.05 ) with OFCs across Asian trios, while another SNP was significant exclusively among Maryland trios.

A total of 205 risk factor associations were found to be nominally significant ( p < 0.05).

Accordingly, 12 nominally significant associations from the abundance-based models and 26 from the presence-based models were identified (p<0.05, figure 5A and online supplemental table S14 ).

In SMR analyses of gene expression and migraine within the Finnish cohort, six genes—EP300, HDAC3, SIRT1, AARS2, SLC16A1, and SMARCA4—showed nominally significant associations ( P < 0.05).

The differential methylation signals contain significant (Bonferroni corrected p < 0.05) and suggestive (uncorrected p < 0.05) DMPs and nominally significant CpGs (uncorrected p < 0.05) within significant DMRs.

Raw P < 0.05 was considered nominally significant, whereas FDR-adjusted P < 0.05 was considered significant after correction for multiple comparisons.

These scores are conservative, as only those SNP—motif pairs are considered where at least one of the SNP alleles had nominally significant ( p < 0.05) similarity with a motif sequence.

Additionally, we observed a range of nominally significant associations ( P < 0.05) with traits spanning reproductive/hormonal traits (such as polyp of female genital tract and female genital prolapse), metabolic traits such as inverse relation with HbA1c, and positive correlations with neoplasms such as breast and bowel cancer ( Supplementary Fig.

We evaluated how well independent pQTLs reported by the INTERVAL study 9 ( n = 3301) replicated in our results and found 75.6% to be both directionally consistent and nominally significant ( P < 0.05) (Supplementary Note 2 and Supplementary Figs. 6 and 7 ).

A total of 19 HLA alleles had nominally significant maternal and/or fetal effects on BW ( P <0.05; Supplementary Table S7 , available as Supplementary data at IJE online); 13 of the 19 alleles had evidence for a maternal effect only, four alleles primarily had evidence for a fetal effect only and two alleles had evidence of both.

Four Hallmark gene sets and six KEGG pathways showed nominally significant enrichment in these results ( p < 0.05, Supplemental Table S5 ), including enrichment of pathways of cytosolic DNA sensing and inflammation (U-PAR, TIMP1, NEMO) and fatty acid and amino acid metabolism (AOC3, CA6).

3 Results 3.1 Proteome‐Wide MR Analysis 6 plasma proteins exhibited a nominally significant causal relationship with OC (FDR‐ p < 0.05); Specifically, TNFSF8, MST1, and NID2 were promoters of OC, and conversely, PLAU, TREML2, and HIBCH were protectors of OC.

Using a nominally significant cutoff ( p < 0.05), 30 module-trait relationships emerge, with a range from zero to six significantly correlated modules per trait.

No pathways were significantly enriched after accounting for multiple testing, however, Panther pathway analyses indicated nominally significant ( P < .05) functional enrichment of several pathways for the UK population: “heterotrimeric G‐protein signaling ‐Gi alpha and Gs alpha mediated” ( P = .01; genes: GRK4 , GRK7 , RGS12 , ADCY2 , ADRA2C , DRD2 ), “Alzheimer disease‐presenilin” ( P = .02; TRPC6 , MMP7 , MMP27 , RBPJ , MMP20 ), “heterotrimeric G‐protein signaling ‐Gq alpha and Go alpha mediated” ( P = .02; GRK4 , GRK7 , CACNA1A , RGS12 , DRD2 ), “ionotropic glutamate receptor” ( P = .03; CACNA1A , SLC17A8 , GRIA4 ), and “axon guidance mediated by semaphorins” ( P = .03; CRMP1 , FYN ).

The 36 nominally significant miRNAs ( p < 0.05) identified in the PDN/PDD comparison from LIMMA were used to classify disease state (See Figure 2B ), though with more limited accuracy than the PD-control model (absolute error rate = 13.8%, sensitivity = 81.2%, specificity = 88.9%).

Given the known prior association with AAA, we used a nominally significant P <0.05 to declare significance.

We selectively included 44 diseases (excluding cancer, which is a limitation to be noted) in the first part of phenome-wide association analysis (PheWAS) and identified nominally significant associations ( P < 0.05) between the SES-associated variants and CHD.

For any medication with a nominally significant association ( p < .05), the same analysis was repeated in the chemotherapy group to test for nonspecific effects.

To obtain stringent TFBS predictions, an empirical score distribution was estimated for each PWM for each species' genome as the set of all nominally significant ( P < 0.05) motif scores identified within the target set of promoter sequences [pwm_scan -s 1 -p ln(0.05)].

Only the volumes of the caudate, corpus callosum and third ventricle achieved a heritability that was nominally significant in our sample (uncorrected P <0.05).

Of these, five showed nominally significant ( p < 0.05) association with MS ( Figure 1 , Table 2 ).

Fisher-Irwin exact tests of association determine the best possible mode of genetic effect at a nominally significant p-value < 0.05.

They first extracted nominally significant signals ( p <0.05) from three GWAS studies (WTCCC, German, and NIMH GAIN datasets; Fangerau et al., 2004 ; Wellcome Trust Case Control Consortium, 2007 ; Baum et al., 2008 ), and prioritized potential candidates based on independent, converging lines of evidence from various bioinformatics resources.