“nominally significant”

Results with IVW- P < 0.05 was considered nominally significant and IVW- P < 0.00045 was taken as statistically significant. 3 Results 3.1 MR results in the discovery stage The list of 110 SRPs was in Table 1 .

Furthermore, we note that when comparing the signals we took for replication (based on case control analyses) with association results with BMI as a continuous trait derived from an independent set of samples from UKBB, there are more directionally consistent and nominally significant associations with BMI than expected by chance suggesting that amongst these loci, there may be additional real associations (binomial p = 4.88x10 -4 , and binomial p = 9.77x10 -3 , respectively, Methods , S9 Table ).” Despite the smaller sample size, the obese vs thin comparison had increased power to detect some loci ( S3 Fig ), including a recently discovered variant near FAM150B [ 32 ] (rs62107261, MAF = ~5%), which did not meet our p<10 −5 threshold to be taken forward for replication in obese vs controls analysis ( p = 2.36x10 -4 ).

A full overview of all 672 nominally significant ( P < 4.95 × 10 −4 ) pQTL-protein pairs between 30 genetic loci and 90 CSF proteins is presented in Supplementary Table 4 .

We did however observe a nominally significant negative association of PTVs in TET2 and proteomic age acceleration (beta = -1.6, SE = 0.5, P = 5×10 –4 , carrier N = 36), supporting the previously highlighted common variant association.

Genome-wide scan of nominally significant regions In a previous eight study meta-analysis, ~12,000 SNPs (INFO > 0.7, MAF > 0.01) were identified as having a nominally significant (p < 5 × 10 −4 ) association with all glioma, GBM, or non-GBM 4 .

We first found some nominally significant SNPs ( p <5 × 10 −4 ) from this preliminary model, and then located the genes corresponding to such SNPs based on the annotation information (T.

However, we detected an eQTL signal tagged by rs11235459 which was nominally significant in both CSF pTau GWAS ( p = 5.4 × 10 –4 , OR = 0.93 [95% CI 0.89–0.97]) and INPPL1 ROSMAP DLPFC eQTL catalogue ( p = 9.1 × 10 –4 , beta = -0.06 [95% CI −0.02 to −0.09]) (Fig. 9 b).

There were some other nominally significant associations in the intergenic region telomeric to the ACRV1 gene (all p ≥5.6x10 -4 ).

Preliminary examination revealed a nominally significant relationship (B=−0.122, t=−1.91, p=0.057 −2 tailed) in this study, following a priori hypothesis of an association of GARS and ASI predictability of risk in which a one-tailed analysis revealed (P=0.028) for the drug severity.

Preliminary examination revealed a nominally significant relationship (B = −0.122, t = −1.91, p = 0.057−2 tailed) in this study, following apriori hypothesis of an association of GARS and ASI predictability of risk in which a one-tailed analysis revealed (P=0.028) for the drug severity (greater than four alleles predicted unspecified drug severity risk).

Each additional copy of a European ancestral allele at 5q13.3 was significantly ( P = 5.8×10 −7 ) associated with an increase in BMI of 0.09 Z-score units (naively equal to ∼0.59 kg/m 2 , accounting for 0.3% of the variance in BMI), which was nominally significant ( P = 5.8×10 −4 ) after correcting for the approximately 1,000 independent hypotheses tested.

The variant identified in the combined resilience GWAS remained nominally significant in the education adjusted residual cognitive resilience analysis (rs2571244, P = 0.0006), suggesting that association is not driven entirely by educational attainment.

Although several nominally significant associations were observed within these strata, none were significant as defined using the pre-specified significance threshold (p < 0.0006).

5.8%; P = 0.90), momelotinib was associated with nominally significant improvements in the rates of total symptom score (TSS) reduction ≥ 50% (26.2% vs. 5.9%; nominal P = 0.0006) and RBC transfusion independence at week 24 (43.3% vs. 21.2%; nominal P = 0.0012) [ 9 ].

rs5933886 also showed nominally significant gender × SNP interaction in both Guangdong ( P = 6.25 × 10 −4 ) and Taiwan datasets ( P = 2.99 × 10 −2 ).

As expected, the gene of ABO showed a nominally significant association with COVID-19 ( P = 6.55 × 10 −4 ) consistent with the previous report ( 11 ).

However, a nominally significant association was revealed at rs16952725 of FTO in males ( P -value = 6.87×10 −4 for BMI and P -value = 8.55×10 −3 for FM), but not in the female specific sample ( P -value = 0.55 for BMI and P -value = 0.43 for FM) ( Table 3 ).

P < 0.05 was considered nominally significant, and P < 6.9 × 10 −4 calculated using Bonferroni correction for multiple comparisons was considered statistically significant, given 72 independent tests for 18 SNPs and four outcomes measured (obesity [BMI], insulin release [InsAUC 0–30 /GluAUC 0–30 ], insulin sensitivity [Matsuda ISI], and proinsulin conversion [ProinsAUC 0–30 /InsAUC 0–30 ]).

In the joint analysis of samples with intravenously derived indices of insulin sensitivity, nominally significant associations were observed between the disease risk allele and reduced insulin sensitivity for the IRS1 ( P = 7 × 10 −4 ) and ADCY5 ( P = 6 × 10 −3 ) loci ( Table 2 and Supplementary Fig. 2 A and B ).

Nominally significant genotype associations at the level of the child were identified for CDKN2A rs36228834 (Child versus Null; P = .0007), CDKN1B rs35756741 (Child versus Null; P = .0235) and CDKN2B rs2069416 (Child versus Null; P = 0.0063); however only CDKN2A rs36228834 and CDKN2B rs2069416 remained significant after multiple testing corrections (Supplementary Table 1).

After adjusted for covariates, the associations between methylation levels of 8 sites and IS were nominally significant, and the associations between methylation levels of CASZ1_70 (adjusted OR = 0.99 [0.98–1.00]; p = 7.26 × 10 −4 ) and CASZ1_67 (adjusted OR = 0.98 [0.98–0.99]; p = 5.54 × 10 −5 ) and IS were significant.

This SNP accounted for a maximum trait variance of 1.83% in PROP paper and showed a weaker but nominally significant association with the perception of PROP solution (P = 7.4e-4).

The CpG main effect of cg24223887 was nominally significant (0.263, p -value = 8.2e-04). 4 Discussion Telomere length is a biomarker of ageing and early-life telomere length relates to later life telomere length and may underlie ageing-related diseases.

Of these NHL-W risk factors, dementia was nominally significant and had a similar effect size in HL (OR 3.7 [1.8–7.0], p = 8.3 × 10 −4 ).

In single-SNP analyses, two of the 13 SNPs showed nominally significant associations with wet AMD (rs2241394, nominal P = 8.32×10 −4 ; rs428453, nominal P = 0.0240), of which only rs2241394 withstood multiple test corrections (corrected empirical P = 0.0102; Bonferroni-corrected P = 0.0108, Table 2 ).