“nominally significant”

In exploratory follow-up analyses without correction for multiple testing, we observed nominally significant associations contralateral in the left OFC ( k = 20, F = 11.15, p = 0.000897, uncorrected, p = 0.606, FWE-corrected) and also in the right lateral occipital cortex ( k = 133, F = 12.7, p = 0.0003968, uncorrected, p = 0.364, FWE-corrected).

However, for three genes, the strength of association with a burden of rare variants was more significant than observed for a single variant test, and in each case, a second nominally significant SNP was observed; LIPG p.Arg476Trp for HDL cholesterol (MAF = 0.18%, P = 9×10 −4 ), LIPC p.Arg208His for LDL cholesterol (MAF = 0.16%, P = 0.02), and ANGPTL4 p.Arg336Cys for triglycerides (MAF = 0.24%, P = 0. 01).

Neighborhood deprivation, smoking status, drinking status, and educational attainment were nominally significant but did not meet the multiple testing threshold ( p < 0.0009).

p value = 1.34E-04) and a nominally significant decrease in de novo PD vs. control ( p value = 9.41E-04; adj. p value = 5.86E-02), is a furan fatty acid previously suggested as a marker for fish oil intake 28 , which could indicate a diet with high levels of omega-3 fatty acids.

Heterozygous carriers of INHBE pLOF variants (1 in 587 individuals, combined frequency of 0.08%) had a favorable metabolic profile consisting of nominally significant associations with lower triglycerides ( P = 9.65 × 10 −4 , Beta = −0.13 SD), higher HDL cholesterol ( P = 0.01, Beta = 0.10 SD), decreased alanine aminotransferase ( P = 0.04, Beta = −0.08 SD) and lower fasting glucose ( P = 0.03, Beta = −0.17 SD).

Rs4905014 has an age-dependent effect on stroke Nominally significant association of rs4905014 was observed with HC ( p = 9.78e-04) and stroke ( p = 3.75e-21) in ARIC, and with DBP ( p = 2.55e-02), HbA1c ( p = 1.44e-02), and HF ( p = 2.58e-02) in MESA (Table 3 ).

The association for rs6445055 remained nominally significant, albeit reduced (p= 9.87×10 −04 , β= −0.121 compared to −0.177 prior to adjustment for CCT).

We found a nominally significant gene-level association for CHRNB3 (gene P = 0.001; Supplementary Data 4 ).

3.2.1 COPD We identified a nominally statistical association between CHRNA3 rs1051730 and COPD risk under the allelic and dominant models in all populations (allelic model: OR = 1.630, 95% CI = 1.293–2.054, p < 0.001; dominant model: OR = 1.662, 95% CI = 1.300–2.124, p < 0.001), a nominally significant association under the allelic and dominant models in Asians (allelic model: OR = 1.591, 95% CI = 1.204–2.103, p = 0.001; dominant model: OR = 1.625, 95% CI = 1.222–2.160, p = 0.001), and a null association under all three models in Caucasians.

Furthermore, when examining CpG sites that were nominally significant (i.e., non-FDR-corrected p-value < 0.001) (n = 3612), we observed overlapping associations between individual PFAS and DNA methylation at 282 specific CpG sites.

While not all previously known DR variants were identified at genome-wide significance in our analyses, we observed an excess of nominally significant associations at these loci (p<0.001, Table B in S1 File ).

Among the 49 patients in the intervention group and 51 in the control group undergoing postoperative chemotherapy, a nominally significant improvement in the change from baseline in the EORTC-QLQ-C30 total score at 3 months was observed compared to the control group (difference of 4.42; P <.001).

The analysis utilized nominally significant SNPs ( p < 0.001) for the four brain regions showing FDR-significant results (right lateral ventricle, right caudate, right pallidum, and right accumbens).

Although a Kruskal–Wallis test detected nominally significant inter-phenotype differences in age ( p = 0.001), this significance did not survive correction for multiple testing (e.g., using FDR adjustment).

For cg23893460, the primary IVW method yielded a nominally significant positive association (OR = 1.29, p < 0.001); however, this was not consistently replicated across other MR methods (all p > 0.05), limiting confidence in this finding.

Among 235 colocalizations with adipose eQTL ( 25 ), 25 (10.6%) also had a nominally significant trait-gene expression association, at an arbitrary P- value threshold of P ≤ 1e−3, despite a sample size of just 859 participants ( Supplementary Table 12 ); 80% of these had consistent effect directions.

Nearly, all pairwise comparisons of the MFIQ UA, PF, SF, and EF scores and the global UA item with the conceptually similar migraine interference level were nominally significant ( P < .001).

This association was identified from the results of the variant rs299290 (T > C; minor allele frequency = 0.25), which was not significant at the genome-wide level, but nominally significant in two study phases 12 , 14 , 19 (combined log-relative risk effect = 0.044, p = 0.001).

Both SNPs remained nominally significant in dichotomized analyses for the presence of any CAC (odds ratio rs1537373 (OR) = 1.19; 95% CI = 1.07-1.31; p = 0.001 and OR rs9349379 = 1.26; 95% CI = 1.14-1.40); p = 1.5x10 -5 ).

Gene ontology (GO) enrichment analysis identified 128 nominally significant enriched terms (see Table S3 for genes included in the analysis) for the DMPs ( P < 0.001) identified in the age 10 analysis, including several related to the etiology of psychosis, such as glutamatergic synaptic transmission (GO:0051966, P = 0.0034) and neuron projection development (GO:0031175, P = 0.0064).

Rs6541998 was genomewide significant in men using sex‐stratified analyses; all other loci were nominally significant ( p < 1 × 10 −3 ) for both men and women with effects in the same direction.

Table 5 presents genome-wide significant and Figure 2 nominally significant results ( P <0.001) of a meta-analysis of the discovery sample and the replication sample.

A total of 13 genes showed a nominally significant ( P < 0.001) association in more than one tissue-specific model (see Table S1 in the supplemental material; see also Fig.

At a nominally significant threshold of p-value ≤ 0.001, GWAS analysis discovered 148 MTAs, pointing to 54 QTLs for the coefficient of infection and 179 MTAs for agronomic traits.

The interaction term of rs1805008:T and latitude was nominally significant in the analysis of Gd-enhancing lesions (interaction- P = 0.001).