“nominally significant”

The results from the linear regression model, adjusted for age and sex covariates, yielded several nominally significant variants in the PTPN2 region including the top finding of rs78943928 ( p = 1.69E−04) which resides approximately 29 and 22 kbp 3′ of PTPN2 isoform 1 and isoform 2, respectively.

These loci were only nominally significant in the analysis including the svPPA patients ( LRP1B : P = 1.72 × 10 −4 ; OR = 4.66, COL22A1 : P = 0.03; OR = 5.32; TMEM135 : P = 1.68 × 10 −3 ; OR = 2.19, and TRPC4 P = 1.25 × 10 −4 ; OR = 2.91).

Reassuringly, the association with a clinical diagnosis of “vitamin D deficiency” (ICD-10 E55; N cases = 3150, N noncases = 344,619) was negative and nominally significant (i.e., higher DBP associated with a reduced risk of a clinical diagnosis of vitamin D deficiency; beta = −0.07, standard error = 0.02, P value < 1.9 × 10 −4 ).

The latter set (of 1286 nominally significant mouse trans -genes) was significantly enriched for overlap with the human trans-network (P<2x10 -4 ).

With the exception of the consumer price index, all the nominally significant variables displayed in Text S1 (Table A) remained highly significant (P<0.0002 or lower) after Bonferroni correction for multiple testing.

Nevertheless, congruent with literature indicating central channels being the most affected in SCZ during auditory processing, all ERP metrics displayed nominally significant group differences at Cz: P50 ratio – e.s. = 0.92 SD, uncorrected p-value = 0.0002, MMN amplitude – e.s. = −0.49 SD, p-value = 0.008, ASSR power – e.s. = –0.56 SD, p-value = 0.008, and ASSR phase synchrony – e.s. = –0.62 SD, p-value = 0.002.

For nominally significant SNPs or genes, we considered a recessive model with a Bonferroni corrected threshold of P = 2.1 × 10 −4 .

Three markers were nominally significant (P-value = 0.00021–0.011; Table S7 ).

In Part 2, we performed a Fisher’s meta-analysis of nominally significant common genes ( P- MS < 0.05, P- IS < 0.05), and 24 shared genes satisfied the strict threshold P value ( P < 2.31E-04).

There was a nominally significant ( p = 2.34 × 10 –4 ) association in males for rs115882880, but no evidence for association ( p > 0.05) in the opposite strata for the other two GWS associations.

Additionally, Campylobacter A showed nominally significant risk enhancement (IVW OR = 1.718, p = 2.64 × 10 −4 , FDR- q = 7.30 × 10 −2 , 95% CI 1.285–2.298), with no evidence of heterogeneity, pleiotropy, or reverse causation ( Tables S5 and S6 ). 3.5.

[ 60 ] for intellectual disability, developmental delay, and/or ASD, DOCK8 is nominally significant for deletions ( P = 0.000281) but not duplications.

Curiously, iHS scores within the LRRK2 locus from 40.2 to 41.0 Mb were nominally significant for rs34637584_G wild-type alleles (GG all = 422, p = 2.95 × 10 −4 to 1.61 × 10 −6 .

A second analysis considering fatty acid composition of nominally significant triacylglycerols, revealed enrichment of triacylglycerols containing C20:4, C18:2 and C16:0 in the PCOS group (p=0.0003, <0.00001 and 0.03, respectively) (also highlighted in Figure 2B ).

Two traits showed nominally significant genetic correlation in both phenotypes but in opposite directions including intelligence (BioVU: rg = −0.53, p = 3 × 10 −4 , UK Biobank: rg = 0.19, p = 0.044) and years of schooling [ 38 ] (BioVU: rg = −0.53, p = 3.3 × 10 −5 , UK Biobank: rg = 0.19, p = 0.007).

Additionally, we identified one variant (rs2588469) that showed genome-wide significant pleiotropic effects (PLEIO p = 1.18 × 10 −8 ), but showed only nominally significant associations with the three disorders investigated (BP: beta = −0.056, p = 0.0003; MDD: OR = 0.98, p = 9.9 × 10 −5 ; SCZ OR = 1.062, p = 0.0008).

Variants in MT-CYB were nominally significant (p = 0.0003): MT-CYB (mitochondrial cytochrome b) is part of the mitochondrial respiratory chain, and essential for Complex III formation.

We also observed a nominally significant eQTL association within the same region of the ABO gene (Supplementary Fig. 2b ) at baseline (eQTL association signal for rs630510, p = 3.0 × 10 −4 in moderate LD r 2 = 0.27 with rs495828 pQTL SNP).

In a large meta-analysis, this SERPINA1 variant had only a nominally significant association with waist-to-hip ratio (beta = −0.03, p = 3.4 × 10 −4 )—the closest anthropometric correlate of VAT/GFAT ratio—highlighting the utility of image-derived phenotypes for this discovery 12 .

However, several lines of evidence point to an effect of the lower dose on exercise endurance: (i) tiotropium/olodaterol 2.5/5 μg significantly improved EET during CWRCE compared with placebo in both MORACTO ® studies [26.5% ( p < 0.0001) and 12.1% ( p = 0.0003)]; (ii) there was a nominally significant improvement in EET during CWRCE after 6 weeks (22.1%, nominal p = 0.0004) in the present study; (iii) in post hoc analysis, change from baseline in EET during CWRCE after 6 and 12 weeks was nominally significant.

We identified several nominally significant associations with average SD-OCT measurements (Table 1 , Supplementary Table S2 ), of which 10 remained significant after multiple testing corrections (p < 0.0004 (0.05/(4 × 33).

Compared to controls, a significant or nominally significant decrease in cerebellar TDP-43 was seen in FTLD-TDP cases in unadjusted analysis (β: − 0.4087, 95% CI: − 0.6325 to − 0.1849, P = 0.0004, Fig. 1 B, Table 2 ) and analysis adjusted for age and sex (β: − 0.2701, 95% CI: − 0.4850 to − 0.05514, P = 0.0142, Table 2 ), respectively.

Phenome-wide association (PheWAS) of n = 10,168 phenotypes revealed nominally significant association of p.Arg1231Cys with ischemic stroke (OR [95%CI] = 4.0 [1.9, 8.6]), p = 4.1 × 10 −4 ), all strokes combined (OR [95% CI] = 1.9 [1.1, 3.5], p = 0.031), hypertension (ICD 10 code I10) (OR [95% CI] = 1.5 [1.1, 2.2], p = 0.019), and recurrent major depression (OR [95% CI] = 3.2 [1.5, 6.8], p = 0.0031) (Supplementary Data 2 ).

This gene was recently identified as nominally significant (genome wide p = 4.2 × 10 –4 ) in a study investigating the role of recessive variants in DD 13 , although more data are required to be confident of its association to DD.

We observed nominally significant association signals in several genes of a priori interest, including BRCA2 (p = 4.3 × 10 −4 ), STK11 (p = 0.003), PALB2 (p = 0.019), and TP53 (p = 0.037), and reported risk estimates for known pathogenic variants and variants of uncertain significance (VUS) in these genes.