“nominally significant”

Differential gene expression analyses of CD11b + cells in VAT and SAT from individuals with obesity revealed nominally significant differences in the gene expression profile (FDR p < 0.05, absolute fold change > 1.5; Figure 1A,B ).

Causal effects of SGLT2 inhibition on gut microbiota and metabolites The IVW method revealed 152 nominally significant associations (p < 0.05) between SGLT2 inhibition and gut microbiota, 173 nominal associations with 249 circulating metabolites, and 220 nominal associations with 486 metabolites ( Figures 3 – 5 ; Supplementary Table S4 ). 3.4.

However, in turn, only a fraction of these present nominally significant ( P < .05) tissue-by-subtype interactions, and hence harbor effects that are different between the 2 tissues (310 of 1204; 25.7%).

Because we expected the signal in bulk tissue to be muted due to cellular heterogeneity, we also evaluated leading edge genes that showed nominally significant DE between younger and older tissue (unadj. p<0.05) ( Figure 5—source data 1A ).

Of the 204 primary meta-analyses performed, nominally significant associations ( P < 0.05) with the risk of sepsis were found with 26 (34%) variants of 21 genes for at least one genetic model containing TLR1 rs5743551-7202A/G; LBP rs2232618 Phe436Leu; the MBL2 A/O haplotype; RAGE rs1800625-429 T/C and rs1800624-374 T/A; NOD2 rs2066844 Arg702Trp and rs2066847 Leu1

RNAi targeting of 17 genes had nominally significant G and/or S × G effects in the full model ANOVAs for cocaine and methamphetamine consumption (ANOVA, P ≤ 0.05; Dataset S9 ).

We evaluated how well independent pQTLs reported by the INTERVAL study 9 ( n = 3301) replicated in our results and found 75.6% to be both directionally consistent and nominally significant ( P < 0.05) (Supplementary Note 2 and Supplementary Figs. 6 and 7 ).

To obtain stringent TFBS predictions, an empirical score distribution was estimated for each PWM for each species' genome as the set of all nominally significant ( P < 0.05) motif scores identified within the target set of promoter sequences [pwm_scan -s 1 -p ln(0.05)].

Association analysis When deviation from strict Mendelian inheritance of individual SNPs was analyzed in Asian trios, three SNPs ( rs10130587 , rs2738265 and rs2761887 ) showed nominally significant evidence of linkage and association (p<0.05) with NSCL/P.

Despite the much narrower range of ages in this cohort, nine (29.03%) of the 31 transcripts for which data were available displayed a nominally significant ( P < 0.05) association between transcript abundance and brain development (Supplemental Table 2), with several transcripts showing highly significant associations with developmental age (Supplemental Fig. 3).

Meta-analyses were deemed free from biases and classified as convincing (Class I) if they satisfied the following criteria: p value <10 − 6 in random-effects meta-analysis; inclusion of more than 1000 participants; low or moderate between-study heterogeneity (I2 <50%); 95% PI excluding the null value; no evidence of small-study effects or excess significance bias; and the largest study showing a nominally significant result (p<0.05).

After removing annotations with three or fewer molecules, we were left with a total of 36 nominally significant ( p < 0.05) groups of genes across a number of categories and function annotations.

Nominally significant associations with p < 0.05 were also reported.

Among the top 10 CpG sites from the meta‐analysis, five CpG sites were at least nominally significant (unadjusted p value < 0.05) in all three cohorts, namely cg18609149 ( AC009950.2 ) for p‐tau, cg00679256 ( RP11‐56I23.1 ) and cg09606840 ( DNPH1 ) for Aβ42+ vs.

The input list of gene IDs was selected based on proximity to the CpGs with consistent and nominally significant (p < 0.05) estimates in all three models.

There were 202 correlations (out of 1425 possible, 14.2%) that were nominally significant, p < 0.05 before correcting for multiple hypotheses testing.

In SMR analyses of gene expression and migraine within the Finnish cohort, six genes—EP300, HDAC3, SIRT1, AARS2, SLC16A1, and SMARCA4—showed nominally significant associations ( P < 0.05).

Four SNPs were nominally significant (p ≤ 0.05) in Cohort 1 and all replicated (p < 0.05) in Cohort 2.

From the genes nominally significant for quadrant differences, 654 genes were differentially expressed ( P < 0.05) for gain; 404 for intake, and the 494 genes for their interaction (Supplemental Table 1 ).

For any medication with a nominally significant association ( p < .05), the same analysis was repeated in the chemotherapy group to test for nonspecific effects.

The NAc miRNA data revealed 430 nominally significant loci, which clustered in 5 modules ranging from 18 (NAcmi green ) to 259 (NAcmi turquoise ) loci in size, of which, at Bonferroni adjusted p ≤0.05, three miRNA modules remained significantly correlated to AD (NAcmi yellow , NAcmi brown , and NAcmi turquiose ).

Survival Pre-HSCT weight, BMI, fat mass, RAPA-Aerobic activity score, Positive Affect, GCGQ score, and ASAS-Wellness all correlated with longer survival; however, these were nominally significant ( p < 0.05) and did not reach significance at our pre-determined level ( p < 0.01).

Raw P < 0.05 was considered nominally significant, whereas FDR-adjusted P < 0.05 was considered significant after correction for multiple comparisons.

Interrogating our GWAS data set for candidate genes that have been previously proposed to be involved in pathogenesis of OM, we found 45 out of 82 genes demonstrated evidence of nominally significant association, with intragenic SNPs or nearby SNPs of P value<0.05; Supplementary Table 6 ), such as SMAD2, SMAD4, NELL1.

Using a nominally significant cutoff ( p < 0.05), 30 module-trait relationships emerge, with a range from zero to six significantly correlated modules per trait.