“nominally significant”

A strong correlation (|r|≥ 0.80) between the gene expression and DNA methylation profiles was observed at 27% of loci (166 CpGs in 153 genes) in HCT116 cells, out of them, 47 CpGs corresponding to 44 genes were nominally significant ( p < 0.05) ( Supplementary Table 3 ) indicating that observed hypermethylations affect cellular function by altering gene expression in cancer cell lines.

Only SNPs with nominally significant p -value < 0.05 in the analysis are shown.

For the ΔHR ex trait, published resting HR SNPs at four loci were genome-wide significant ( SOX5 , RNF220 , SYT10 and PPIL1 ), while 25 additional loci were nominally significant (5 × 10 −8 < P < 0.05; Supplementary Data 2 ).

Among the top 10 CpG sites from the meta‐analysis, five CpG sites were at least nominally significant (unadjusted p value < 0.05) in all three cohorts, namely cg18609149 ( AC009950.2 ) for p‐tau, cg00679256 ( RP11‐56I23.1 ) and cg09606840 ( DNPH1 ) for Aβ42+ vs.

Nominally significant differences ( P < 0.05) were deemed ‘transgene-altered’ correlations.

We evaluated how well independent pQTLs reported by the INTERVAL study 9 ( n = 3301) replicated in our results and found 75.6% to be both directionally consistent and nominally significant ( P < 0.05) (Supplementary Note 2 and Supplementary Figs. 6 and 7 ).

Because we expected the signal in bulk tissue to be muted due to cellular heterogeneity, we also evaluated leading edge genes that showed nominally significant DE between younger and older tissue (unadj. p<0.05) ( Figure 5—source data 1A ).

To obtain stringent TFBS predictions, an empirical score distribution was estimated for each PWM for each species' genome as the set of all nominally significant ( P < 0.05) motif scores identified within the target set of promoter sequences [pwm_scan -s 1 -p ln(0.05)].

In SMR analyses of gene expression and migraine within the Finnish cohort, six genes—EP300, HDAC3, SIRT1, AARS2, SLC16A1, and SMARCA4—showed nominally significant associations ( P < 0.05).

RNAi targeting of 17 genes had nominally significant G and/or S × G effects in the full model ANOVAs for cocaine and methamphetamine consumption (ANOVA, P ≤ 0.05; Dataset S9 ).

Raw P < 0.05 was considered nominally significant, whereas FDR-adjusted P < 0.05 was considered significant after correction for multiple comparisons.

A total of 19 HLA alleles had nominally significant maternal and/or fetal effects on BW ( P <0.05; Supplementary Table S7 , available as Supplementary data at IJE online); 13 of the 19 alleles had evidence for a maternal effect only, four alleles primarily had evidence for a fetal effect only and two alleles had evidence of both.

Throughout this manuscript associations are referred to as nominally significant ( p < 0.05) or study-wide significant (corrected for the 9 independent SNPs; p < 5.5 × 10 -3 ).

Variants that had both a directionally opposite, nominally significant association (p < 0.05) with log-BUN and a directionally concordant, nominally significant association with eGFR cysC were defined as validated loci.

Using a nominally significant cutoff ( p < 0.05), 30 module-trait relationships emerge, with a range from zero to six significantly correlated modules per trait.

After removing annotations with three or fewer molecules, we were left with a total of 36 nominally significant ( p < 0.05) groups of genes across a number of categories and function annotations.

Nominally significant associations with p < 0.05 were also reported.

Genes were considered significantly modulated by etrolizumab if they had an absolute fold change ≥ 1.5, at an FDR of < 0.05 in the combined colonic and ileal analysis, and were nominally significant (unadjusted p value < 0.05) in both the colonic- and ileal-only analyses.

For any medication with a nominally significant association ( p < .05), the same analysis was repeated in the chemotherapy group to test for nonspecific effects.

A total of 205 risk factor associations were found to be nominally significant ( p < 0.05).

The input list of gene IDs was selected based on proximity to the CpGs with consistent and nominally significant (p < 0.05) estimates in all three models.

Nominally significant association across the three populations ( P < 0.05) was observed for 33 SNPs of 344, with P values ranging from P = 1.79 × 10 −5 to P = 0.050 (supplementary Table 3).

There were 202 correlations (out of 1425 possible, 14.2%) that were nominally significant, p < 0.05 before correcting for multiple hypotheses testing.

We retained for downstream analyses all loci with nominally significant binomial p values ( p < 0.05) and at least 2 reads (10%) mapped to any allele.

Four SNPs were nominally significant (p ≤ 0.05) in Cohort 1 and all replicated (p < 0.05) in Cohort 2.