“nominally significant”

Four SNPs were nominally significant (p ≤ 0.05) in Cohort 1 and all replicated (p < 0.05) in Cohort 2.

From the genes nominally significant for quadrant differences, 654 genes were differentially expressed ( P < 0.05) for gain; 404 for intake, and the 494 genes for their interaction (Supplemental Table 1 ).

Results for the well-being score were all directionally consistent but none were nominally significant ( P < 0.05). 4. 2-sample MR with non-overlapping depression GWAS Using the PA and ST instruments identified in our MRLap analysis we provide further evidence for the role of PA in depression using the summary statistics from the Wray et al.

However, E2F2 , ZC3HC1 , RMI1 , JAK2 , EXOC3L1 , and CSF2RB are nominally significant ( P < 0.05), also in the small non-European sample, when adjusting for lead GWAS hits ( Table 3 ).

Survival Pre-HSCT weight, BMI, fat mass, RAPA-Aerobic activity score, Positive Affect, GCGQ score, and ASAS-Wellness all correlated with longer survival; however, these were nominally significant ( p < 0.05) and did not reach significance at our pre-determined level ( p < 0.01).

To obtain stringent TFBS predictions, an empirical score distribution was estimated for each PWM for each species' genome as the set of all nominally significant ( P < 0.05) motif scores identified within the target set of promoter sequences [pwm_scan -s 1 -p ln(0.05)].

Among the top 10 CpG sites from the meta‐analysis, five CpG sites were at least nominally significant (unadjusted p value < 0.05) in all three cohorts, namely cg18609149 ( AC009950.2 ) for p‐tau, cg00679256 ( RP11‐56I23.1 ) and cg09606840 ( DNPH1 ) for Aβ42+ vs.

Raw P < 0.05 was considered nominally significant, whereas FDR-adjusted P < 0.05 was considered significant after correction for multiple comparisons.

In SMR analyses of gene expression and migraine within the Finnish cohort, six genes—EP300, HDAC3, SIRT1, AARS2, SLC16A1, and SMARCA4—showed nominally significant associations ( P < 0.05).

For example, for cg18181703 in SOCS3 the correlations estimated for each of these relative pairs as well as grandparent–grandchildren were nominally significant ( P value < 0.05), and were 0.01 to 0.15 greater than our expected correlation.

As shown in Table 2 , although in our GWAS none of the two SOX6 gene SNPs achieved nominally significant p values ( p <0.05) for univariate association with BMI, FM or hip BMD, both SNPs achieved p values of 10 −6 to 10 −7 for bivariate association with BMI-hip BMD or FM-hip BMD.

Our MR analysis was conducted as an exploratory study, and the results were considered nominally significant at P < 0.05 [ 27 ].

Using a nominally significant cutoff ( p < 0.05), 30 module-trait relationships emerge, with a range from zero to six significantly correlated modules per trait.

For any medication with a nominally significant association ( p < .05), the same analysis was repeated in the chemotherapy group to test for nonspecific effects.

A total of 19 HLA alleles had nominally significant maternal and/or fetal effects on BW ( P <0.05; Supplementary Table S7 , available as Supplementary data at IJE online); 13 of the 19 alleles had evidence for a maternal effect only, four alleles primarily had evidence for a fetal effect only and two alleles had evidence of both.

A total of 205 risk factor associations were found to be nominally significant ( p < 0.05).

As suggested by a previous study 4 , most of these lead variants at T2D loci in either the Japanese or European population showed at least nominally significant ( P < 0.05) associations in the alternative population, even if not genome-wide significant, except for variants that were rare or monomorphic in one population such as NKX6-1 rs201597274, HNF1A rs187150787, and PAX4 rs2233580 in the Japanese population and HNF1A rs56348580 in the European population.

All nominally significant associations (P<0.05) are listed.

A scatter plot of SNPs with at least nominally significant ( p < 0.05) effects on both BMI and T2D was generated using RStudio with the ggplot2 package, and Pearson correlation between BMI and T2D-associated signals calculated in R using the cor() function.

Furthermore, when applying a sequential analysis approach in an N-of-1 framework, we were able to determine that 13 of the 15 individuals with nominally significant systolic blood pressure changes, and 14 of the 18 individuals with diastolic blood pressure changes over six months demonstrated this trend (p < 0.05) by the fifth month of their study enrollment.

Step 5: We generate a ranked list of drug repositioning candidates and MOA categories that show enrichment of nominally significant ( p < 0.05) gene-based associations (MAGMA and S-PrediXcan) across compounds within each category.

The 36 nominally significant miRNAs ( p < 0.05) identified in the PDN/PDD comparison from LIMMA were used to classify disease state (See Figure 2B ), though with more limited accuracy than the PD-control model (absolute error rate = 13.8%, sensitivity = 81.2%, specificity = 88.9%).

Results Differential expression Overall, 7565 genes were differentially expressed (nominally significant p < 0.05) in small intestinal biopsies between cases with a-CD and controls, and 5244 genes remained differentially expressed after adjusting for multiple comparisons.

The higher relative abundance for these taxa was nominally significant in carriers ( P ≤ 0.05), but non-significant after correction for multiple testing which is not unexpected given the small sample size.

Out of 14 shared knowns that had genome-wide significant associations in OE, 7 had nominally significant ( p < 0.05) and directionally consistent associations in MCDS.