“nominally significant”

Nominally significant ( p -value < 0.05) proteins in model 1 were validated in the KORA-Age1 study using the same model 1.

In childhood blood samples, these differences in blood DNAm of MTNR1B CpGs were nominally significant ( p < 0.05) and retained the same positive direction, suggesting persistence of associations.

Evidence Classification and Quality Assessment Each unique association that was nominally significant ( p -value < 0.05) was classified as strong evidence (Class I), highly suggestive evidence (Class II), suggestive evidence (Class III) or weak associations (Class IV), with regard to epidemiological validity criteria ( Table S2 ) [ 21 ].

330 CpG sites annotated to candidate genes were retrieved and screened for nominally significant longitudinal effects ( p < 0.05).

After aggregation, two genes reached Bonferroni significance, while 118 genes were nominally significant ( p < 0.05) in other cell types—these are referred to as cell-type-enriched genes.

The nominally significant genes (i.e., gene-based p -values ≤ 0.05) were mapped onto the HPRD PPI network [ 26 , 27 ] and analyzed using the iPINBPA method in order to identify the enriched subnetworks.

eQTL analysis of the remaining 26 loci (69 protein-coding genes) identified 22 SNP-gene combinations that were nominally significant ( t -test P < 0.05) in all, ER+ or ER− breast cancers (Supplementary Data 6 ), nine of which remained significant after taking account of multiple testing (FDR adjusted t -test P < 0.1,Table 3 ).

For the ΔHR ex trait, published resting HR SNPs at four loci were genome-wide significant ( SOX5 , RNF220 , SYT10 and PPIL1 ), while 25 additional loci were nominally significant (5 × 10 −8 < P < 0.05; Supplementary Data 2 ).

Studies) below Metabolome Wide Significance Level (MWASL) threshold (p = 2.4 * 10E–9 to 1.1 * 10E–5) with Ln[CACs + 1] mannose, alanine and acetaminophen-glucuronide strongly associated yet glutamate and histidine had strong inverse associations besides other significant metabolites also remained nominally significant (p < 0.05) but by 50% weaker association; furthermore, lipoprotein subcategories of total plasma cholesterol, total plasma apolipoprotein B and apolipoprotein B within total plasma LDL significantly associated with Ln[CACs + 1] in model-3 (further adjusted for model-1 + nonlipid CVD risk factors of SBP, DM, Smoking status, and use of medication for hypercholesterolemia, BP or DM).”.

From the GO based analysis, 465 nominally significant ( p < 0.05) terms were identified as enriched within the 374 genes ( Supplementary Table 2 ).

Number of comorbidities and number of treatment sessions have nominally significant effects ( P < 0.05) on post-treatment scores ( β = 0.09 and β = − 0.02, respectively).

The first 10 PCs were included in FG and FI analyses, and nominally significant PCs ( P <0.05) were added in T2DM analyses.

Of the 204 primary meta-analyses performed, nominally significant associations ( P < 0.05) with the risk of sepsis were found with 26 (34%) variants of 21 genes for at least one genetic model containing TLR1 rs5743551-7202A/G; LBP rs2232618 Phe436Leu; the MBL2 A/O haplotype; RAGE rs1800625-429 T/C and rs1800624-374 T/A; NOD2 rs2066844 Arg702Trp and rs2066847 Leu1

None of the individual SNPs in the CCT-GRS were associated with OAG after correction for multiple testing, however 10 SNPs were nominally significant ( P < 0.05 uncorrected for multiple testing; Supplementary Table S5 ).

However, five tag SNPs for TMPRSS2 were associated with COVID-19 test positivity at the nominally significant level ( p < 0.05) in both analyses using all other UKB participants and individuals who were tested negative as the controls ( Table 2 ).

Among the top 10 CpG sites from the meta‐analysis, five CpG sites were at least nominally significant (unadjusted p value < 0.05) in all three cohorts, namely cg18609149 ( AC009950.2 ) for p‐tau, cg00679256 ( RP11‐56I23.1 ) and cg09606840 ( DNPH1 ) for Aβ42+ vs.

Mediation analyses involving all other pollution markers also had positive indirect effect estimates with nominally significant P values ( P ≤ 0.05; Table S3 in supporting information).

In accordance with the findings in mice, a nominally significant ( P <0.05) association between CDKAL1 rs4712523 and BMI was replicated in 2 Japanese general populations comprising 5,695 and 12,569 samples; the risk allele for type 2 diabetes was also associated with decreased BMI.

Although not all the GO annotations listed in the downregulated gene category passed multiple test correction, they were nominally significant ( P < 0.05) and functionally linked.

Only SNPs with nominally significant p -value < 0.05 in the analysis are shown.

Differential gene expression analyses of CD11b + cells in VAT and SAT from individuals with obesity revealed nominally significant differences in the gene expression profile (FDR p < 0.05, absolute fold change > 1.5; Figure 1A,B ).

A total of 205 risk factor associations were found to be nominally significant ( p < 0.05).

In SMR analyses of gene expression and migraine within the Finnish cohort, six genes—EP300, HDAC3, SIRT1, AARS2, SLC16A1, and SMARCA4—showed nominally significant associations ( P < 0.05).

We evaluated how well independent pQTLs reported by the INTERVAL study 9 ( n = 3301) replicated in our results and found 75.6% to be both directionally consistent and nominally significant ( P < 0.05) (Supplementary Note 2 and Supplementary Figs. 6 and 7 ).

Using a nominally significant cutoff ( p < 0.05), 30 module-trait relationships emerge, with a range from zero to six significantly correlated modules per trait.