“nominally significant”

In addition, the ovarian cancer patients had a nominally significant decrease in the number of 12 and 22 genotype carriers compared to the controls (p = 0.05) suggesting that the duplication may be protective for the disease with an odds ratio of 0.72 (95% CI, 0.53–0.99).

Nominally significant ( p -value < 0.05) proteins in model 1 were validated in the KORA-Age1 study using the same model 1.

330 CpG sites annotated to candidate genes were retrieved and screened for nominally significant longitudinal effects ( p < 0.05).

The list contained the nearest gene within a 500 kb window to each nominally significant SNP ( P < 0.05).

Of the 204 primary meta-analyses performed, nominally significant associations ( P < 0.05) with the risk of sepsis were found with 26 (34%) variants of 21 genes for at least one genetic model containing TLR1 rs5743551-7202A/G; LBP rs2232618 Phe436Leu; the MBL2 A/O haplotype; RAGE rs1800625-429 T/C and rs1800624-374 T/A; NOD2 rs2066844 Arg702Trp and rs2066847 Leu1

We found 7 variants that showed nominally significant individual associations ( P ≤ .05) with earlier ANM.

Differential abundance analysis identified 98 metabolites with nominally significant differences ( p < 0.05), though none survived FDR correction (0.238 < q < 0.296), likely reflecting the modest sample size.

Among the age-associated sites identified in our study population, 12 sites were nominally significant ( P < 0.05) with Cd exposure group after adjustment ( Table 2 ).

Black lines connect pairs that surpassed p<2.5e-10 in the discovery cohort (UKB), blue lines connect pairs of loci with nominally significant interaction (p<0.05) in the replication cohort, and gray lines connect pairs of genes with p<2.5e-10 in the final meta-analysis.

After aggregation, two genes reached Bonferroni significance, while 118 genes were nominally significant ( p < 0.05) in other cell types—these are referred to as cell-type-enriched genes.

Effect estimates for most proteins remained consistent after adjustment for these factors, but standard errors increased such that only Nt-proBNP, CXCL13 and the complement factors remained significant at the Bonferroni-adjusted threshold (Table 2 ) although all proteins except IL-1RA and tPA remained nominally significant at p < 0.05.

Notably, our data indicated a nominally significant enrichment ( P <0.05, 1 million permutations) of credible MPB SNPs in enhancer regions from DPCs (treated with dihydrotestosterone, DHT), which further supports the hypothesis that DPCs are involved in MPB aetiology 25 (Fig. 2; Supplementary Data 1 ).

For the ΔHR ex trait, published resting HR SNPs at four loci were genome-wide significant ( SOX5 , RNF220 , SYT10 and PPIL1 ), while 25 additional loci were nominally significant (5 × 10 −8 < P < 0.05; Supplementary Data 2 ).

eQTL analysis of the remaining 26 loci (69 protein-coding genes) identified 22 SNP-gene combinations that were nominally significant ( t -test P < 0.05) in all, ER+ or ER− breast cancers (Supplementary Data 6 ), nine of which remained significant after taking account of multiple testing (FDR adjusted t -test P < 0.1,Table 3 ).

We generated a similarity matrix across all GO terms nominally significant ( p < 0.05) in at least one comparison using the calculateSimMatrix function.

While some numerical differences existed in the proportions of patients who underwent open vs laparoscopic surgery across the four warming treatment arms, this difference was not found to be nominally significant (P > 0.05) on post-hoc testing of the distribution using a chi-squared test.

In childhood blood samples, these differences in blood DNAm of MTNR1B CpGs were nominally significant ( p < 0.05) and retained the same positive direction, suggesting persistence of associations.

A strong correlation (|r|≥ 0.80) between the gene expression and DNA methylation profiles was observed at 27% of loci (166 CpGs in 153 genes) in HCT116 cells, out of them, 47 CpGs corresponding to 44 genes were nominally significant ( p < 0.05) ( Supplementary Table 3 ) indicating that observed hypermethylations affect cellular function by altering gene expression in cancer cell lines.

Evidence Classification and Quality Assessment Each unique association that was nominally significant ( p -value < 0.05) was classified as strong evidence (Class I), highly suggestive evidence (Class II), suggestive evidence (Class III) or weak associations (Class IV), with regard to epidemiological validity criteria ( Table S2 ) [ 21 ].

From the GO based analysis, 465 nominally significant ( p < 0.05) terms were identified as enriched within the 374 genes ( Supplementary Table 2 ).

Additionally, for each of the 594 eGFR signals, we queried further genetic association data relevant to the kidney researcher: (7) To highlight the relevance of a genetic association with creatinine-based eGFR for kidney function rather than creatinine metabolism, we included information on whether the locus association was directionally consistent and nominally significant for blood urea nitrogen (BUN) or cystatin-based eGFR (eGFRcys; i.e. locus lead variant P < 0.05; opposite or same direction of effect for BUN or eGFRcys, respectively; n = 852,678 or 460,826, respectively; yielding 491 of 594 signals validated); (8) Since genetic effects with steeper decline versus more stable eGFR over time might point to particularly deleterious mechanisms for the kidney, we included information on whether the signal showed significant association on eGFR decline (N = 343,339 [ 25 ], yielding 8 decline signals).

The nominally significant genes (i.e., gene-based p -values ≤ 0.05) were mapped onto the HPRD PPI network [ 26 , 27 ] and analyzed using the iPINBPA method in order to identify the enriched subnetworks.

Among the top 10 CpG sites from the meta‐analysis, five CpG sites were at least nominally significant (unadjusted p value < 0.05) in all three cohorts, namely cg18609149 ( AC009950.2 ) for p‐tau, cg00679256 ( RP11‐56I23.1 ) and cg09606840 ( DNPH1 ) for Aβ42+ vs.

Studies) below Metabolome Wide Significance Level (MWASL) threshold (p = 2.4 * 10E–9 to 1.1 * 10E–5) with Ln[CACs + 1] mannose, alanine and acetaminophen-glucuronide strongly associated yet glutamate and histidine had strong inverse associations besides other significant metabolites also remained nominally significant (p < 0.05) but by 50% weaker association; furthermore, lipoprotein subcategories of total plasma cholesterol, total plasma apolipoprotein B and apolipoprotein B within total plasma LDL significantly associated with Ln[CACs + 1] in model-3 (further adjusted for model-1 + nonlipid CVD risk factors of SBP, DM, Smoking status, and use of medication for hypercholesterolemia, BP or DM).”.

Number of comorbidities and number of treatment sessions have nominally significant effects ( P < 0.05) on post-treatment scores ( β = 0.09 and β = − 0.02, respectively).