“nominally significant”

The PC1 expression model showed a nominally significant relationship with activity in BA 9 (uncorrected p <0.0001); however, this relationship did not withstand multiple testing correction (corrected p = 0.093).

Nominally significant decreased DCM risk was found to be associated with the A allele and AT genotype of rs2505568 (OR: 0.48, 95% CI = 0.35–0.67, p < 0.0001 and OR: 0.44, 95% CI = 0.31–0.62, p < 0.0001, respectively), but it should be interpreted with caution because of Hardy-Weinberg disequilibrium in the control group.

Here, despite the sample size limitation, we observed consistent GO or disease enrichments using different web-based tools or different gene lists, indicating that the nominally significant findings ( P < 1 × 10 −4 ) and the coexpressed genes with GRIA4 are robustly related to the ND+MD trait.

This GWAS showed nominally significant association of rs1006737 located in intron 3 of CACNA1C ( P =1 × 10 −4 ) with BD. 5 Subsequently, a larger GWAS with 4387 BD cases and 6209 controls, including overlapping samples from the first study, further supported the association of rs1006737, now reaching borderline genome-wide significance

rs35346340 is a significant FURIN eQTL in esophageal mucosa ( P = 2.0E-13) and a nominally significant eQTL of this gene in aortic artery ( P = 1.0E-04), and FURIN is highly expressed in both primary and immortalized cardiac fibroblasts.

Given this lack of statistical significance in hierarchical testing, adjusted mean changes from baseline in total lesion volume on T2-weighted (T2W) images at 12 months and 24 months in the siponimod group were considered nominally significant versus placebo (both timepoints p < 0.0001) (Table 1 ), with the adjusted average mean increase from baseline over both timepoints lower in the siponimod than placebo group (183.9 vs 879.2 mm 3 ; nominal p < 0.0001) [ 38 ].

Specifically, there was a nominally significant increase in the proportion of neutrophils (beta = 0.025, p = 0.0001), and a decrease in the proportion of monocytes (beta = -0.007, p = 2.1e-6), CD8 + T cells (beta = -0.007, p = 0.025), and NK cells (beta = -0.009, p = 1.2e-5) (Table S3 ).

Nominally significant MetaXcan results ( p < 10 −4 ) were investigated using gene set enrichment analysis. 2.8 Look‐Up of Results From Prior WL in COPD GWAS We compared significant results from our prior GWAS of WL in COPD [ 9 ] with results from the current analyses.

In the gene-based analysis, 976 genes were found to have genome-wide association ( P ≤ 0.05) that could be defined as the nominally significant GWAS geneset (NSGG), 9 of which were suggestively associated with milk yield ( P < 10 −4 ).

When quantifying the number of samples that are not heterozygous for a known eQTL but still show allelic imbalance, gene-level haplotypic expression levels were excluded for a sample if the individual was heterozygous for a top significant eQTL or a nominally significant (permutation p < 1e−4) independent eQTL in any of the 49 tissues.

Aggregating results from several large-scale cis-eQTL studies across tissues 9 , 34 , we found that 12 of the 59 of the (enrichment p value = 2.8 × 10 −05 ) novel genes have nominally significant ( p value <1 × 10 −04 ) evidence of cis-regulatory SNPs to be associated with SCZ or other different neuropsychiatric diseases.

All comparisons were nominally significant ( P < 0.0001).

From the common single-nucleotide variants (SNVs) analysis, we identified the abnormal nominally significant ( P < 1 × 10 −4 ) common SNVs enriched in PTBP3 gene.

Combined South Asian meta-analysis revealed nominally significant association in six SNPs with MAF >5% ( P ≤ 10 −4 ), but only the two previously known SNPs in TCF7L2 and IGF2BP2 reached genome-wide significance ( Table 1 and Supplementary Table 8 ).

The top 20 nominally significant CpGs ( p < 0.0001, but q > 0.05) are listed in Tables S2–S3.

We performed colocalization analyses for each of the identified loci with an nominally significant eQTL ( p < 0.0001) and assumed a single causal variant within the window tested (lead eQTL SNP +/− 200KB).

Pathway analyses conducted on nominally significant targets showed that genes associated with BD and BMI were enriched for the Neuronal cell body Gene Ontology (GO) term ( p = 1.0E−04; false discovery rate (FDR) = 0.025) and different pathways, including the Signaling by Hedgehog pathway ( p = 4.8E−05, FDR = 0.02), while genes associated with BD and T2D showed no specific enrichment.

Comparison of the difference in the proportion of FAERS reports with the NITL terms in drugs with and without the relevant labeling was nominally significant ( p < 0.0001; Kruskal–Wallis ChiSquare approximation).

3 , 12 Among the 32 nominally significant gene-based associations ( P < 1.00 × 10 − 4 ), six (18.75%) were issued from a missense|LC (i.e., low-confidence LoF variants) burden set, 19 (59.38%) were issued from a pLoF burden set, and seven (21.88%) were issued from a synonymous burden set ( Supplementary Figure S1 ).

A total of 22 metabolites comprising 11 known metabolites and 11 unknown metabolites showed nominally significant relation ( P > 1.03 × 10 −4 but P < 0.05, IVW method) to HF ( Table 1 ).

The inclusion of covariates slightly reduced the association p -value of the loci ( P = 7.01 × 10 −8 ; without covariate analysis), showing a nominally significant effect of Bristol stool scale ( P = 1.13 × 10 −4 ).

In the current study, we demonstrate nominally significant hypermethylation at both loci (Fig. 4 a: cg05066959: ∆ = 13.10, P = 1.13 × 10 −4 and Fig. 4 b: cg11823178: ∆ = 9.39, P = 5.48 × 10 −5 ), in parallel with a nominally significant decrease in uC (cg11823178: ∆ = − 5.03, P = 1.19 × 10 −3 ; cg05066959: ∆ = − 9.06, P = 1.18 × 10 −4 ), and a nominally significant decrease in 5hmC at cg11823178 (∆ = − 4.36, P = 0.02), with a non-significant decrease in 5hmC at cg05066959 ( ∆ = − 4.04, P = 0.14).

For 10 out of 29 brain regions a nominally significant relationship could be observed: Right Hippocampus (rho = 0.86, −log(p) = 3.84), Brainstem (rho = 0.85, −log(p) = 3.56), left Hippocampus (rho = 0.84, −log(p) = 3.41), left Basal Ganglia vessels (rho = 0.82, −log(p)= 2.90), left Choroid Plexus (rho = 0.73, −log(p) = 2.05), right Basal Ganglia vessels (rho = 0.69, −log(p) = 1.86), right ventral Diencephalon (rho = 0.65, −log(p) = 1.56), right Caudate (rho = 0.64, −log(p) = 1.56), right Accumbens area (rho = 0.61, −log(p) = 1.41), and right Amygdala (rho = 0.60, −log(p) = 1.32) (Table 2 and Figure 3A ).

While the lack of available expression data to assign SRS in external cohorts limits our ability to validate our findings, we did find that one previously reported mortality-associated variant, rs72998754, 67 was in strong LD (r 2 = 0.98 in 1KGP EUR) with nominally significant SNPs in our SRS GWAS ( p = 0.00015).

Nominally significant differences between groups indicate a higher protein (p=1.54×10 −4 ), lower fat (p=0.026) and lower alcohol (p=3.8×10 −4 ) content for the TLS group.