“nominally significant”

In total, 35 miRNAs revealed a nominally significant (P<0.05) difference in the microarray analysis between the two study groups.

Meta-analysis suggested that genetically proxied statin use was negatively associated with the order Actinomycetales, the family Actinomycetaceae, and the genera Actinomyces , Ruminococcus gnavus group , Eisenbergiella , and Erysipelatoclostridium at a nominally significant level ( P < 0.05) ( Figure 3 A ; Table S4 ).

Among the age-associated sites identified in our study population, 12 sites were nominally significant ( P < 0.05) with Cd exposure group after adjustment ( Table 2 ).

Most of these loci are not even nominally significant ( P < 0.05) in comparison studies.

The results were considered nominally significant at the level of p < 0.05.

Of the 204 primary meta-analyses performed, nominally significant associations ( P < 0.05) with the risk of sepsis were found with 26 (34%) variants of 21 genes for at least one genetic model containing TLR1 rs5743551-7202A/G; LBP rs2232618 Phe436Leu; the MBL2 A/O haplotype; RAGE rs1800625-429 T/C and rs1800624-374 T/A; NOD2 rs2066844 Arg702Trp and rs2066847 Leu1

Nominally significant ( p -value < 0.05) proteins in model 1 were validated in the KORA-Age1 study using the same model 1.

Twenty-eight out of 34 genes we initially identified were testable by this approach and 18 of them showed nominally significant clustering of de novo missense mutations (p < 0.05, CLUMP, one-tailed permutation test).

3.3 Univariate linear regression analysis Among the 831 features investigated, 42 showed a nominally significant difference at a p = .05 level between the n-3 LCPUFA supplementation and the placebo group.

Seven genera showed nominally significant IVW associations with endometriosis ( P <0.05): Lactococcus , Olsenella , Senegalimassilia , Ruminococcaceae UCG-002, Holdemania , Eubacterium ruminantium group and Anaerotruncus .

Of the 144 SNP subsets examined, 132 demonstrated nominally significant concordant effects (OR > 1 and p < 0.05) across migraine (dataset 1) and T2D (dataset 2), while 141 SNP subsets showed significant concordant effects across headache (dataset 1) and T2D (dataset 2).

For both definitions of alcohol dependence (ALDX1 and ALDX2), we found 12 genomic regions with nominally significant LOD scores ( p < 0.05, Table 2 ).

330 CpG sites annotated to candidate genes were retrieved and screened for nominally significant longitudinal effects ( p < 0.05).

2 ; Supplementary Figures 1 , 2 ), and a nominally significant p-value (unadjusted p-value < 0.05) was used to define FSCV DEGs in these signatures.

Genetically predicted older age at first sexual intercourse (AFS), AAM, and elevated sex hormone-binding globulin (SHBG) levels were suggestively associated with increased odds of achieving 90th percentile longevity, while genetically predicted levels of follicle-stimulating hormone (FSH) had the opposite effect (nominally significant, p < 0.05).

Excess significance test was used to investigate whether the observed number of studies (O) with nominally significant results (‘positive’ studies, p<0.05) was larger than the expected number of significant results (E).

Nominally significant results ( p < 0.05 in interaction tests and stratified genotypes analysis) were further pursued by applying the same Cox proportional hazards regression models to the FHS (incident AD) and ADNI data (MCI to AD conversion).

A nominally significant ( p-value < 0.05) association was observed when counting duplications only (OR = 1.10, p = 0.02).

To determine which, if any, pathways may be altered, we took any nominally significant values ( p < 0.05) either from only the single-cell analysis or from the intersection of the single-cell and pseudobulk analyses and performed Gene Ontology enrichment analysis.

A strong correlation (|r|≥ 0.80) between the gene expression and DNA methylation profiles was observed at 27% of loci (166 CpGs in 153 genes) in HCT116 cells, out of them, 47 CpGs corresponding to 44 genes were nominally significant ( p < 0.05) ( Supplementary Table 3 ) indicating that observed hypermethylations affect cellular function by altering gene expression in cancer cell lines.

From the GO based analysis, 465 nominally significant ( p < 0.05) terms were identified as enriched within the 374 genes ( Supplementary Table 2 ).

An additional analysis of the current study data suggests that, when compared to placebo with no concomitant use of AHM, tadalafil provides small nominally significant drops ( p ‐value < .05) in BP of less than 1.5 mmHg and often less than 1.0 mmHg.

Loneliness likely involves additional brain regions, since all 13 brain regions included in the enrichment analyses depicted in Figure 2 were nominally significant with P < 0.05.

eQTL analysis of the remaining 26 loci (69 protein-coding genes) identified 22 SNP-gene combinations that were nominally significant ( t -test P < 0.05) in all, ER+ or ER− breast cancers (Supplementary Data 6 ), nine of which remained significant after taking account of multiple testing (FDR adjusted t -test P < 0.1,Table 3 ).

Following this filtering process, bivariate local genetic correlation analyses were exclusively conducted for pairs of SCZ and each of the imaging phenotypes that exhibited a nominally significant univariate local genetic signal ( P < 0.05).