“nominally significant”

Tier A molecules represented stringent, nominally significant (p < 0.05) miRNAs generated from RNA-Seq quantification that also showed a strong trend (p < 0.10) and directionally consistent changes in the microarray experiments.

Additionally, for each of the 594 eGFR signals, we queried further genetic association data relevant to the kidney researcher: (7) To highlight the relevance of a genetic association with creatinine-based eGFR for kidney function rather than creatinine metabolism, we included information on whether the locus association was directionally consistent and nominally significant for blood urea nitrogen (BUN) or cystatin-based eGFR (eGFRcys; i.e. locus lead variant P < 0.05; opposite or same direction of effect for BUN or eGFRcys, respectively; n = 852,678 or 460,826, respectively; yielding 491 of 594 signals validated); (8) Since genetic effects with steeper decline versus more stable eGFR over time might point to particularly deleterious mechanisms for the kidney, we included information on whether the signal showed significant association on eGFR decline (N = 343,339 [ 25 ], yielding 8 decline signals).

After adding the reduced Morningness-Eveningness Questionnaire (rMEQ) total score and the ISI to separate regression models, we found that the patterns of association were similar, with many of the previously significant associations remaining nominally significant ( p < 0.05), albeit attenuated in magnitude.

A total of 7 SNPs (related to genes FNTB, MVD, PDSS1, and PDSS2) showed a nominally significant association ( p < 0.05) with the BP-induced change in spine BMD, whereas 15 SNPs (in FDPS, FNTA, FNTB, IDI1, MVD, MVK, PDSS1, and PDSS2 genes) were associated with hip BMD changes ( Table 2 ).

Regarding descriptive statistics on rumination, gender, age, lifetime psychiatric problems, and present somatic disorders, Supplementary Table 1 shows that except for frequency of pain problems there are differences between the Budapest and Manchester subsamples in all variables at either a nominally significant ( p ≤ 0.05) or trend (0.05 < p ≤ 0.10) level.

To evaluate astroglial proliferation, we imaged N = 36 Tg( Gfap -luc) RML prion-infected and N = 14 uninfected mice by BLI every 7–11 days, and pre-specified that a single 500 μg dose of ASO 1, 2 or 3 would be administered after two consecutive imaging sessions showed a nominally significant ( P < 0.05 by a two-sided Kolmogorov–Smirnov test) difference in BLI between infected and uninfected mice.

In subgroup analysis, the six VTE risk genes were nominally significant ( P < 0.05) in both female and male groups and showed the same effect directions as in the full sample (Supplementary Fig. 2 ).

In total, 35 miRNAs revealed a nominally significant (P<0.05) difference in the microarray analysis between the two study groups.

Among the age-associated sites identified in our study population, 12 sites were nominally significant ( P < 0.05) with Cd exposure group after adjustment ( Table 2 ).

First, in step A, we screened for the presence of nominally significant ( P < 0.05) cumulative effects of associated methylation sites in whole blood, to determine which factors and variables to include in the full-scale analysis, thereby minimizing false positive findings in the downstream analysis.

Gene set enrichment analyses Enrichment analyses of Gene Ontology (GO) terms [ 45 ] and Reactome pathways [ 46 ] were performed in g:Profiler [ 47 ] with nominally significant ( p < 0.05) genes derived from the cross-ancestry, gene-based meta-analysis.

The Radial plot method was used to select eligible resting heart-rate associated genetic variants for fitness by removing heterogeneous outliers for the genetic variants, of which 149 were also nominally significant in the fitness GWAS ( p < 0.05) [ 28 ].

However, in turn, only a fraction of these present nominally significant ( P < .05) tissue-by-subtype interactions, and hence harbor effects that are different between the 2 tissues (310 of 1204; 25.7%).

Nominally significant ( p -value < 0.05) proteins in model 1 were validated in the KORA-Age1 study using the same model 1.

Meta-analysis suggested that genetically proxied statin use was negatively associated with the order Actinomycetales, the family Actinomycetaceae, and the genera Actinomyces , Ruminococcus gnavus group , Eisenbergiella , and Erysipelatoclostridium at a nominally significant level ( P < 0.05) ( Figure 3 A ; Table S4 ).

Most of these loci are not even nominally significant ( P < 0.05) in comparison studies.

The results were considered nominally significant at the level of p < 0.05.

The rs35705950-T allele was not associated with reduced COVID-19 positivity in transancestry meta-analysis within the MVP (N cases = 19,168/N controls = 492,854; OR, 0.98 [0.95–1.01]; P = 0.06) but was nominally significant ( P < 0.05) in the joint meta-analysis with the HGI (N cases = 44,820; N controls = 1,775,827; OR, 0.97 [0.95–1.00]; P = 0.03).

330 CpG sites annotated to candidate genes were retrieved and screened for nominally significant longitudinal effects ( p < 0.05).

After aggregation, two genes reached Bonferroni significance, while 118 genes were nominally significant ( p < 0.05) in other cell types—these are referred to as cell-type-enriched genes.

eQTL analysis of the remaining 26 loci (69 protein-coding genes) identified 22 SNP-gene combinations that were nominally significant ( t -test P < 0.05) in all, ER+ or ER− breast cancers (Supplementary Data 6 ), nine of which remained significant after taking account of multiple testing (FDR adjusted t -test P < 0.1,Table 3 ).

For the ΔHR ex trait, published resting HR SNPs at four loci were genome-wide significant ( SOX5 , RNF220 , SYT10 and PPIL1 ), while 25 additional loci were nominally significant (5 × 10 −8 < P < 0.05; Supplementary Data 2 ).

Six of these 13 associations were directionally consistent, but none were nominally significant (p<0.05).

From the GO based analysis, 465 nominally significant ( p < 0.05) terms were identified as enriched within the 374 genes ( Supplementary Table 2 ).

Of the 204 primary meta-analyses performed, nominally significant associations ( P < 0.05) with the risk of sepsis were found with 26 (34%) variants of 21 genes for at least one genetic model containing TLR1 rs5743551-7202A/G; LBP rs2232618 Phe436Leu; the MBL2 A/O haplotype; RAGE rs1800625-429 T/C and rs1800624-374 T/A; NOD2 rs2066844 Arg702Trp and rs2066847 Leu1