“nominally significant”

The nominally significant p -value was defined as 0.006 ≤ p < 0.050, indicating suggestive evidence for potential causality.

Genes with nominally significant differential expression ( p < 0.05) between the chronic and acute time points in untreated or P. gingivalis - or C. pneumoniae -treated ApoE -/- mice are tabulated in Figure 3 .

No significant or nominally significant (P < 0.05) associations with glucose or insulin traits including fasting or 2 hour glucose and insulin from the OGTT, Insulin AUC, Glucose AUC, Matsuda Index or HOMA-IR were found for any of the SNPs in the Amish after adjustment for age and sex.

A nominally significant IVW result ( P < .05) was considered evidence of a potential causal effect if β estimates were consistent in direction across methods and sensitivity analyses showed no significant pleiotropy or heterogeneity.

As most results were nominally significant (P < 0.05) but did not meet the stringent corrected threshold (P < 0.005), they are cautiously interpreted as indicating potential trends in the discussion of our findings.

Six of these 13 associations were directionally consistent, but none were nominally significant (p<0.05).

Even among nominally significant DEGs (nDEGs p < 0.05; cortex n = 1567; striatum n = 906; cerebellum n = 487), there was limited overlap, with significant similarities being seen only among downregulated genes (Fig. 2 c and Supplementary Table 4), indicating that the effects of Mbd5 reduction are largely different across these three brain regions.

However, a plot of the p -values for all genes tested in the psychENCODE cohort revealed that there are many nominally significant genes (unadjusted p -value <0.05) that failed to reach the threshold of statistical significance following multiple testing (Supplementary Fig. 3 ) suggesting that this small cohort might be underpowered.

Additionally, for each of the 594 eGFR signals, we queried further genetic association data relevant to the kidney researcher: (7) To highlight the relevance of a genetic association with creatinine-based eGFR for kidney function rather than creatinine metabolism, we included information on whether the locus association was directionally consistent and nominally significant for blood urea nitrogen (BUN) or cystatin-based eGFR (eGFRcys; i.e. locus lead variant P < 0.05; opposite or same direction of effect for BUN or eGFRcys, respectively; n = 852,678 or 460,826, respectively; yielding 491 of 594 signals validated); (8) Since genetic effects with steeper decline versus more stable eGFR over time might point to particularly deleterious mechanisms for the kidney, we included information on whether the signal showed significant association on eGFR decline (N = 343,339 [ 25 ], yielding 8 decline signals).

Loneliness likely involves additional brain regions, since all 13 brain regions included in the enrichment analyses depicted in Figure 2 were nominally significant with P < 0.05.

The rs35705950-T allele was not associated with reduced COVID-19 positivity in transancestry meta-analysis within the MVP (N cases = 19,168/N controls = 492,854; OR, 0.98 [0.95–1.01]; P = 0.06) but was nominally significant ( P < 0.05) in the joint meta-analysis with the HGI (N cases = 44,820; N controls = 1,775,827; OR, 0.97 [0.95–1.00]; P = 0.03).

Among the age-associated sites identified in our study population, 12 sites were nominally significant ( P < 0.05) with Cd exposure group after adjustment ( Table 2 ).

Tier A molecules represented stringent, nominally significant (p < 0.05) miRNAs generated from RNA-Seq quantification that also showed a strong trend (p < 0.10) and directionally consistent changes in the microarray experiments.

In subgroup analysis, the six VTE risk genes were nominally significant ( P < 0.05) in both female and male groups and showed the same effect directions as in the full sample (Supplementary Fig. 2 ).

However, a nominally significant (i.e., unadjusted p < .05) group difference was found in average thalamic radiation MD bilaterally (TBI < OI).

To evaluate astroglial proliferation, we imaged N = 36 Tg( Gfap -luc) RML prion-infected and N = 14 uninfected mice by BLI every 7–11 days, and pre-specified that a single 500 μg dose of ASO 1, 2 or 3 would be administered after two consecutive imaging sessions showed a nominally significant ( P < 0.05 by a two-sided Kolmogorov–Smirnov test) difference in BLI between infected and uninfected mice.

After adding the reduced Morningness-Eveningness Questionnaire (rMEQ) total score and the ISI to separate regression models, we found that the patterns of association were similar, with many of the previously significant associations remaining nominally significant ( p < 0.05), albeit attenuated in magnitude.

In total, 35 miRNAs revealed a nominally significant (P<0.05) difference in the microarray analysis between the two study groups.

Among the 38 genes in the TRAIL pathway, seven genes achieved nominally significant association with hip OF ( p <0.05); the TNFSF10 ( TRAIL ) gene obtained the most significant p value ( p = 1.70×10 −4 ).

Although none of these comparisons reached the significance threshold after adjustment for multiple comparisons (3.69 × 10 −5 ), 179 were nominally significant ( p < 0.05) ( Supplementary Table S6a ).

Of the 204 primary meta-analyses performed, nominally significant associations ( P < 0.05) with the risk of sepsis were found with 26 (34%) variants of 21 genes for at least one genetic model containing TLR1 rs5743551-7202A/G; LBP rs2232618 Phe436Leu; the MBL2 A/O haplotype; RAGE rs1800625-429 T/C and rs1800624-374 T/A; NOD2 rs2066844 Arg702Trp and rs2066847 Leu1

The Radial plot method was used to select eligible resting heart-rate associated genetic variants for fitness by removing heterogeneous outliers for the genetic variants, of which 149 were also nominally significant in the fitness GWAS ( p < 0.05) [ 28 ].

Nominally significant ( p -value < 0.05) proteins in model 1 were validated in the KORA-Age1 study using the same model 1.

In a per-protein analysis, replacing values below the limit of detection with protein specific LOD-values, five proteins (CSF-1, NTRK3, ICOSLG, SCF and PECAM-1) were found to have nominally significant differences between the two time-points (p < 0.05, Wilcox test).

330 CpG sites annotated to candidate genes were retrieved and screened for nominally significant longitudinal effects ( p < 0.05).