“nominally significant”

To obtain correlation results with enough statistical power, we included metabolites with nominally significant genetic heritability ( P < 0.05).

We observed 1054 (7.7%) nominally significant associations ( p < 0.05; Supplementary Data 2 ), and 21 associations (0.2%) were statistically significant at a 5% false discovery rate (FDR), corresponding to p < 6.76 × 10 −5 (Figs. 2 and 3 and Table 1 ).

To reduce the multiple testing burden, candidate TFs were tested for interaction with a given gene only if their marginal association with the target probe set was nominally significant ( p <0.05).

To this end, a threshold to the cluster height was gradually reduced until a Kruskal–Wallis test of the gene-specific minimum p values from the eQTL analysis indicated nominally significant heterogeneity between the emerging sub-clusters (Kruskal–Wallis p < 0.05).

No significant or nominally significant (P < 0.05) associations with glucose or insulin traits including fasting or 2 hour glucose and insulin from the OGTT, Insulin AUC, Glucose AUC, Matsuda Index or HOMA-IR were found for any of the SNPs in the Amish after adjustment for age and sex.

None of the individual SNPs in the CCT-GRS were associated with OAG after correction for multiple testing, however 10 SNPs were nominally significant ( P < 0.05 uncorrected for multiple testing; Supplementary Table S5 ).

There were 26602 nominally significant ( P -value < 0.05) CpG sites ( Figure 1 ).

A nominally significant result was determined at the P < 0.05 threshold.

None of these loci was even nominally significant ( p > 0.05) in the Han Chinese subgroup.

However, 119 metabolites including choline, tryptophan betaine, indole, ornithine, three acylcarnitines, four cholesteryl esters, two lysophosphatidylcholines, five long-chain diglycerides, and 101 unsaturated (very) long-chain triglycerides were nominally significant with P < 0.05, suggesting potential links between these metabolites and early revision.

The Radial plot method was used to select eligible resting heart-rate associated genetic variants for fitness by removing heterogeneous outliers for the genetic variants, of which 149 were also nominally significant in the fitness GWAS ( p < 0.05) [ 28 ].

Six of these 13 associations were directionally consistent, but none were nominally significant (p<0.05).

While some numerical differences existed in the proportions of patients who underwent open vs laparoscopic surgery across the four warming treatment arms, this difference was not found to be nominally significant (P > 0.05) on post-hoc testing of the distribution using a chi-squared test.

Tier A molecules represented stringent, nominally significant (p < 0.05) miRNAs generated from RNA-Seq quantification that also showed a strong trend (p < 0.10) and directionally consistent changes in the microarray experiments.

Additionally, for each of the 594 eGFR signals, we queried further genetic association data relevant to the kidney researcher: (7) To highlight the relevance of a genetic association with creatinine-based eGFR for kidney function rather than creatinine metabolism, we included information on whether the locus association was directionally consistent and nominally significant for blood urea nitrogen (BUN) or cystatin-based eGFR (eGFRcys; i.e. locus lead variant P < 0.05; opposite or same direction of effect for BUN or eGFRcys, respectively; n = 852,678 or 460,826, respectively; yielding 491 of 594 signals validated); (8) Since genetic effects with steeper decline versus more stable eGFR over time might point to particularly deleterious mechanisms for the kidney, we included information on whether the signal showed significant association on eGFR decline (N = 343,339 [ 25 ], yielding 8 decline signals).

The rs35705950-T allele was not associated with reduced COVID-19 positivity in transancestry meta-analysis within the MVP (N cases = 19,168/N controls = 492,854; OR, 0.98 [0.95–1.01]; P = 0.06) but was nominally significant ( P < 0.05) in the joint meta-analysis with the HGI (N cases = 44,820; N controls = 1,775,827; OR, 0.97 [0.95–1.00]; P = 0.03).

After adding the reduced Morningness-Eveningness Questionnaire (rMEQ) total score and the ISI to separate regression models, we found that the patterns of association were similar, with many of the previously significant associations remaining nominally significant ( p < 0.05), albeit attenuated in magnitude.

The nominally significant p -value was defined as 0.006 ≤ p < 0.050, indicating suggestive evidence for potential causality.

Although no striatal gene expression changes reached significance following FDR correction (FDR <0.1) in HTT-ASO-treated YAC128 mice at the 6-month time point, we identified 105 downregulated and 148 upregulated genes that were nominally significant ( p < 0.05) in response to treatment ( Table S2 ).

In subgroup analysis, the six VTE risk genes were nominally significant ( P < 0.05) in both female and male groups and showed the same effect directions as in the full sample (Supplementary Fig. 2 ).

In total, 35 miRNAs revealed a nominally significant (P<0.05) difference in the microarray analysis between the two study groups.

To evaluate astroglial proliferation, we imaged N = 36 Tg( Gfap -luc) RML prion-infected and N = 14 uninfected mice by BLI every 7–11 days, and pre-specified that a single 500 μg dose of ASO 1, 2 or 3 would be administered after two consecutive imaging sessions showed a nominally significant ( P < 0.05 by a two-sided Kolmogorov–Smirnov test) difference in BLI between infected and uninfected mice.

Of the 204 primary meta-analyses performed, nominally significant associations ( P < 0.05) with the risk of sepsis were found with 26 (34%) variants of 21 genes for at least one genetic model containing TLR1 rs5743551-7202A/G; LBP rs2232618 Phe436Leu; the MBL2 A/O haplotype; RAGE rs1800625-429 T/C and rs1800624-374 T/A; NOD2 rs2066844 Arg702Trp and rs2066847 Leu1

330 CpG sites annotated to candidate genes were retrieved and screened for nominally significant longitudinal effects ( p < 0.05).

Among the age-associated sites identified in our study population, 12 sites were nominally significant ( P < 0.05) with Cd exposure group after adjustment ( Table 2 ).