“nominally significant”

Nominally significant genetic correlations were also found between AD and T2DM ( r g = 0.155, p = 0.048), and ASD and MetS ( r g = 0.115, p = 0.002).

Indeed, minor differences in populations with few and rare events may provide nominally significant results (e.g. p=0.048) which however appear quite unstable.

Mediation Analyses (Amyloid-Stratified Causal Framework) Across 721 SCFA–taxon combinations, one species ( Clostridiales bacterium within Oscillospiraceae ) showed a nominally significant mediation of valeric acid’s relationship with Aβ status (ACME p = 0.048) ( Figure 7 ; Supplementary Table S5 ).

A nominally significant correlation was noted between adjusted PAT and heart failure (genetic correlation [rG]=0.36, standard error [se]=0.18, P =0.048).

In Model 2, dietary zinc density showed a nominally significant positive association with cfPWV (B = 0.271; 95% CI: 0.0018 to 0.540; p = 0.048).

Furthermore, a nominally significant association was found between equal distribution of relative income and better overall HRQoL ( B = − 3.55, p = 0.048).

For EPB41L2 , although the IVW estimate was nonsignificant ( P > 0.05), the weighted median method yielded a nominally significant protective effect (odds ratio = 0.601, 95% confidence interval: 0.646–0.777, weighted median P = 0.048), providing suggestive evidence for a causal role.

The 16q24.3 rs1126464 in DPEP1 showed a nominally significant association with tHCY, and its allele effect was similar to that observed in the discovery ExWAS ( β = −0.11, p = 0.048, Table 1 ).

Causal effect of OSA on LSB/PA IVW analysis revealed a nominally significant association between OSA and MVPA (OR = 0.97, 95% CI = 0.94–0.99, p = 0.048).

The univariable MR estimates were nominally significant for the effect of genetically high IL-2ra (IVW β = 0.001; 95% CI, 8.7 × 10 − 6 to 0.002; P = 0.048) or IL-4 (IVW β = 0.003; 95% CI, 0.001 to 0.005; P = 0.003) or monokine induced by gamma interferon (MIG) (IVW β = 0.002; 95% CI, 0.0008 to 0.003; P = 0.001) or MIP1b (IVW β = 0.002; 95% CI, 0.0007 to 0.003; P = 0.003) with eGFRcrea, also indicating the protective role of these systemic inflammatory regulators on kidney function.

Specifically, while the miR-499 rs3746444 recessive model showed a nominally significant association ( P = 0.048), this association was no longer significant after Bonferroni correction. 4 Discussion MicroRNAs (miRNAs) have emerged as pivotal regulators of gene expression and tumorigenesis, acting as either oncogenes or tumor suppressors depending on the cellular context ( 16 ).

observed that ABCB1 rs1045642 has an additive protective effect against cardiotoxicity (OR = 0.48, 95% CI = 0.23–1.00, p = 0.049), and the results remained nominally significant after correction for clinical covariates ( p = 0.048) [ 48 ].

As in the schizophrenia spectrum group, we found that functional connectivity among the individually-specified ROIs yielded estimates of PANSS positive subscale scores in the bipolar patients, with a mild-moderate, and nominally significant, correlation ( r = 0.35, p = 0.048, Fig. 4 ).

We detected nominally significant heterogeneity (p = 0.048) among the data sets in the rs6500843 analysis, indicating some disagreement between data sets; the SNP-associated increased hazard was not seen in the SUCCESS-A data set.

Although the effect of experimental condition on the constant term was nominally significant, this test did not survive Bonferroni correction for multiple comparisons ( t (21) = 2.101, p = 0.048).

Overall, at 6 months, the risk of the composite vascular endpoint (vascular death, myocardial infarction, or stroke) did not differ between treatment groups ( p = 0.52), while analysis of functional outcome (shift in modified Rankin Scale (mRS) using ordinal logistic regression) suggested a nominally significant ( p = 0.048) higher risk of poor outcome in the candesartan group (not significant after multiple testing correction at p ≤ 0.025).

In the overall paired analysis, postoperative decreases in tricuspid E-wave velocity, tricuspid E/e′ and an increase in tricuspid systolic annular velocity were nominally significant (raw P = 0.048, 0.027 and 0.031), but these findings did not remain significant after within-table FDR correction (adjusted P = 0.288, 0.279 and 0.279, respectively).

We found rs17591250 was nominally significant in the EUR population (OR = 0.563, P = 0.04842), however we again observed a flip in the OR, which could be explained by the difference in allele frequencies in the different populations.

However, there were two nominally significant causal relationships that hyperthyroidism was associated with an increased risk of order MollicutesRF9 (id.11579) (OR=1.067, 95% CI: 1.0003-1.138, P =0.0488), while hypothyroidism was associated with an increased risk of genus Ruminococcaceae UCG005 (OR=1.038, 95% CI: 1.001-1.078, P =0.0497). 4 Discussion This study comprehensively assessed the causal effects of 211 taxonomic groups within the domain of Genus and Species (from phylum to genus levels) on thyroid function, encompassing parameters such as FT4, TSH, hypothyroidism, and hyperthyroidism.

The putatively identified compound ivermectin B1b was found to be nominally significantly different between green and yellow peppers ( p -value = 0.0488), while all-trans-retinyl oleate was close but not below the nominally significant threshold for red vs. yellow peppers ( p -value = 0.0523). 2.5.

The T allele of rs10912116 was significantly associated with a decreased odds of relapse in both males [OR 0.77, 95% CI 0.63, 0.94, p = 8.87 × 10 –3 ] and females [OR 0.59, 95% CI 0.47, 0.74, p = 5.07 × 10 –6 ] and the sex by SNP interaction was nominally significant (p = 4.89 × 10 –2 ).

39 MAGMA reported a nominally significant enrichment of TCF4 target genes amongst schizophrenia risk loci ( P = .049) after correcting for gene length and LD.

Difference in seizure reduction between CBD and placebo emerged on Day 6 (titrated dose, 15 mg/kg/day) and became nominally significant ( p < .049) by Day 10.

The observed association for rs350845, which is linked to higher SIRT6 levels is nominally significant ( P = 0.049).

Among 21 candidate variants including genes in the interferon response pathway, APOE , TMPRSS2 , TLR3 , the HLA complex and the ABO blood group, only rs1205, a 3’ untranslated region variant in the CRP gene, showed nominally significant association in T-dominant model analyses (odds ratio 1.859, 95%CI 1.001–3.453, p = 0.049) after adjustment for age, sex, center, body mass index, and a history of cardiovascular disease.