“nominally significant”

Using Wilcoxon signed rank tests with clustered data for each phenotype, all were nominally significant (0.028 < p < 0.044; Table S5 ).

Only the NTB for thrombocytopenia was nominally significant in favor of UFT, though the effect size was quite small (NTB = −0.8%; 95% CI, −1.6 to −0.0%; P = .044).

The GWA of mtDNA-CN based on CHARGE Consortium and UK Biobank cohorts ( n = 24,622; median follow-up 4318 days) found a nominally significant association between mtDNA haplotypes and the overall non-external mortality ( p = 0.044) [ 31 ].

After adjusting for age, sex, years of education and APOE -ε4 carrier status, PHS (status) showed a strong association in all three contrasts involving CN subjects ( P ≤ 4.32e-06), while there was only a nominally significant effect between MCI and Alzheimer’s disease ( P = 0.044; Table 2 ).

In ZMSC, a nominally significant association between cigarettes smoked per day and decline in Haemophilus[g] abundance was also observed ( β = − 0.789, se = 0.392, p = 0.044) (Fig. 3 d).

For the third footshock, there was a nominally significant effect of age on the distance traveled (age effect, F 3,56 = 2.88, P = 0.0441; age × time interaction, F 42,784 = 1.76, P = 0.0025), and post hoc comparisons revealed that there were no significant differences in the total distance traveled during and after the footshock between age groups.

Regression analysis using alpha diversity indicator Chao1 as the predictor of changes of WLZ (12–5 months) showed a nominally significant negative regression model: WLZ = –0.010 * Chao1 + 1.309 ( P = 0.045).

We observed nominally significant differences in PRS distributions, with younger individuals (< 40 years) having higher PRS (p = 0.045) compared to older individuals, and carriers of rare variants having lower PRS compared to non-carriers (p = 0.037).

In this sensitivity analysis, the mADF group showed a nominally significant association with lower REE values compared with the MedDiet group ( p = 0.045).

ALS had nominally significant global genetic correlations with schizophrenia (p = 0.045), PD (p = 0.013), and AD (p = 0.006); no other bivariate genome-wide correlations were statistically significant (see Figure 2 ).

Water intake was also found to have a nominally significant inverse association with ON risk (OR = 0.19, 95% CI: 0.04–0.96, P = .045); However, this association did not remain statistically significant following FDR correction (FDR-adjusted P = .054).

A large number of preplanned exploratory analyses were performed in the PLATO trial, and a nominally significant treatment interaction for geographic region ( P = 0.045) was observed.

Little signal was seen for DEGs enriched for FMRP target genes in the genotype × stimulus interaction analyses, with a nominally significant enrichment ( p = 0.045) in the LA but not significant enrichment in MA or PFC.

The exploratory SCN1A + subgroup analysis (79% of study participants) showed a nominally significant reduction from baseline in convulsive seizure frequency ( p = .045) with soticlestat versus placebo.

There was a nominally significant increase in VLDL triglyceride transfer to cells only in the MedDiet‐Nuts arm relative to the control diet (+0.39 SD units, 95% CI 0.012–0.78, p ‐value = 0.045).

Among females, the NIE of mtDNA-CN on risk of MCI or AD was mediated only by C5-OH ( P = 0.007), whereas nominally significant NIE through C18:2 ( P = 0.045) and glycine ( P = 0.042) was observed in males (Table 3 , Additional file 2: Table S8).

A ceramide/sphingomyelin factor (CS factor 4, composed primarily of glucosylceramides and ceramides), not significant in the full combined analysis, was nominally significant in the LABS and RYGB subgroup analyses: (OR = 1.58, p = 0.045 and OR = 1.92, p = 0.026, respectively).

Simple t -tests contrasting the trait values of those recombinants subjected to WGS- or MSG-based genotyping were not significant in most cases ( p > 0.1 for lobe area, height, width, height-to-width ratio, PC2, and PC3), and only nominally significant in one case that does not survive correction for multiple testing ( p = 0.045 for PC1).

IGFBP1 expression was found to be nominally significant in inflamed UC samples (p = 0.045), possibly predicting treatment escalation.

However, a nominally significant interaction was observed for sex ( P = 0.045), suggesting that females may have higher odds of self-harm ideation than males across alcohol consumption levels, despite similar J-shaped patterns (Supplementary Fig. 4 ).

One additional interaction was nominally significant before FDR correction but did not survive multiple testing adjustment: CETP –macronutrient interaction with LDL-C (unadjusted p = 0.0454, FDR p = 0.1086).

The present analysis showed a nominally significant difference in PTDM incidence between the overall ECD versus SCD groups (17.3% [89 of 513] vs. 12.7% [67 of 526], p=0.0455).

Look-up of genes associated with ectopic pregnancy in previous literature ( ADGRD1 ( GPR113 ), VEGFA, IL8 , IL6 , ESR1 , and EGFR ) revealed that none of them passed the Bonferroni correction threshold and only GPR113 (also known as ADGRD1 ) and ESR1 were nominally significant ( P = 0.046 and P = 0.044, respectively).

However, T2D still showed nominally significant (IVW p = 0.046, MR‐EGGER p = 0.026).

Two other regions showed nominally significant replication p values in AA ( SEMA3C , p = 0.046) and HISP ( ISX , p = 0.014), but not in NHW.