The set of 37 monogenic obesity genes showed a weaker but also nominally significant enrichment (2.05-fold enrichment, P = 0.034).
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C3 showed a nominally significant risk association under the weighted median model (OR = 1.651, P = .034).
SLE status was significantly associated with reduced XCI-skew in 40–49 years (p=9.4×10 −4 ) and 50–59 years (p=9.8×10 −4 ), after Bonferroni correction (alpha=0.0125), and nominally significant in the over 60 years group (p=0.034; online supplemental figure S1 ).
From pre- to post-intervention ( Table 2 ), a nominally significant improvement in IL-6 was observed across all participants ( p = 0.034, effect size = 0.879, 95% CI = 0.879–0.879).
Nominally significant genetic correlations were observed between cognitive disorganization with schizophrenia ( r g = 0.19, p = 0.034) and depression ( r g = 0.40, p = 0.006) and between anhedonia and depression ( r g = 0.33, p = 0.021).
In this study, although a nominally significant difference was observed in COVES between groups in the univariate analysis ( p = 0.034), this finding was not robust after false discovery rate correction (FDR-corrected, p = 0.129), indicating that the observed association may be marginal and should be interpreted with caution.
This specific observation reached a nominally significant association (r=-0.19; p=0.034; table 3 ).
A nominally significant (p=0.034) improvement was observed in global alpha AEC-c.
Results A nominally significant association was found between the G-allele of 941G/T in MAO-A and ADHD (TDT: P = 0.034.
Hydration interactions on the cheeks were nominally significant before multiplicity (right cheek β interaction = 3.58, p = 0.034, q = 0.103; left cheek β _interaction = 2.81, p = 0.017, q = 0.077) but did not meet the FDR threshold, which, given the modest sample and group imbalance (38 vs. 15), raises the possibility of both Type I (false positives) and Type II (false negatives).
Specifically, adolescent MDD patients in the replication cohort exhibited nominally significant reductions in λ ( t = −2.14, P = 0.0342), L p ( t = −2.35, P = 0.0203), and E local ( t = −2.01, P = 0.0467).
Nominally significant protective associations were also observed for higher eosinophil (OR = 0.9883, 95% CI = 0.9777–0.9991, P = .0344, FDR = 0.1148) and lymphocyte counts (OR = 0.9858; 95% CI = 0.9745–0.9972, P = .0148, FDR = 0.0739).
Nominally significant associations were observed in 12 of the 18 steroid metabolites in VDAART (range of p -values = 0.035 to 4.05 × 10 −5 ), and 11 of 12 associations retained significance at an FDR < 0.05 cutoff ( Table S2 ).
Smokers had higher APITH of SCNAs ( t -test p = 0.035, nominally significant) but similar APITH of methylation compared with non-smokers.
Among the seven highlighted cancer types, we saw a multiply-corrected significant positive estimate for combined head/neck cancer (OR 1.51, p = 0.001), and nominally significant positive estimates for colorectal (OR 1.21, p = 0.035) and oesophageal (OR 1.42 p = 0.033) cancer.
Notably, in an analysis of a multiethnic dataset with unrelated AD cases and controls from the Alzheimer’s disease sequencing project (ADSP; Table 1 ), rs74074811 showed nominally significant association of these same two RIN3 mutations with AD risk in the Hispanic population ( P = 0.035).
In the overall study population, the proportion of patients in corticosteroid-free remission at week 44 was significantly greater in the q8w group ( P =0.004) and nominally significant in the q12w group ( P =0.035; as per hierarchical testing procedure) than with placebo ( Supplementary Fig. 4 ).
In the prelimbic cortex, there was a nominally significant difference in Gdap1 DNAm ( F (1,29) = 4.92, p = 0.035, mean ± SD DNAm AUD = 4.07% ± 0.41%, mean ± SD DNAm Ctrl = 3.66% ± 0.59%, Figure 6 E).
Whilst the HTT region itself did not show nominal enrichment in either the entorhinal cortex or cerebellum, in the entorhinal cortex nominally significant enrichment was observed at GRK4 (chr4:2930232–3052474, P = 0.035).
Cross‐fostering had a nominally significant effect on the DNA methylation pattern for Pde4d (Fline: F 1,37 = 4.81; p = 0.035) but significantly interacted with genetic line (Line × Fline: F 1,37 = 9.22; p = 0.004; Figure 1A ).
HR is however only nominally significant in PAD (p-value = 0.035).
The three nominally significant CpG sites exceeding the 5% biological relevance threshold cg03543593 in TNXB ( p = 0.035), cg09451613 in TACC2 ( p = 0.009), and cg09413492 in MUC12 ( p = 0.047) remained nominally significant across the models.
Among the 14 items assessed, only the frequency of consuming Mediterranean-style sautéed dishes showed a nominally significant difference between the sexes ( p = 0.035).
The difference in the proportions of patients with ≥1 TEAE (10.3%; 95% confidence interval, −0.3% to −21.0%) was nominally significant ( P = .0355).
From the Type 2 Diabetes Knowledge Portal ( http://www.type2diabetesgenetics.org/ , searched on 3.26.2018), we found that nominally significant associations between rs2296966 and risk of DM were observed in three previous studies, including BioMe AMP T2D GWAS (OR = 0.838, p = 0.036), GWAS SIGMA (OR = 1.13, p = 0.0232), and GoT2D WGS (OR = 1.25, p = 0.0483), from different populations.