“nominally significant”

34 Analyzing heritability enrichment on the tissue group level using s-LDSC with both annotation approaches, we found enrichment for brain tissue with both GTEx (coefficient p = 0.0038) and ATAC-seq annotations (coefficient p = 0.0072), whereas immune tissue enrichment was nominally significant only using ATAC-seq annotations (coefficient p = 0.032; Fig 1 ).

Dietary pattern showed nominally significant associations with barriers related to taste and texture, meal preparation knowledge, and preparation time (all p ≤ 0.032); none survived Benjamini-Hochberg correction across 12 simultaneous tests (false discovery rate-adjusted p ≥ 0.062).

Supplementary data thorax-2023-220856supp002.xlsx Causal estimate for seropositive RA on IPF The primary IVW-FE analysis gave a nominally significant result for a protective causal effect of seropositive RA on IPF (OR 0.93; 95% CI 0.87 to 0.99; p=0.032) ( figure 2A and online supplemental table 6A ).

GlycanAge was significantly lower in the active group compared to the inactive group (β = -7.437, p.adj = 7.85E-03), and nominally significant and increased in professional athletes compared to the active group (β = 7.546, p = 3.20E-02).

Interestingly, one suggestive signal for tau‐PET on Chr7 ( CRYGN,RHEB /rs12538040, MAF = 0.196, P = 3.80E‐07, β = −0.84) was also nominally significant with the same direction for p‐tau217 ( P = 0.032, β = −0.21). 3.4 Mult‐trait GWAS Multi‐trait GWAS was performed on a subset of 76 participants from ABC‐DS with all four tau biomarker measurements available, aiming to identify pleiotropic loci that simultaneously contribute to all tau biomarkers.

There is a nominally significant rs11854251‐ LINC00923 association in the spinal cord (cervical c‐1) ( p = 0.032).

Interaction between the 5-HTTLPR genotype and total RLE score on current depressive symptoms Interaction with the total RLE score was nominally significant in the combined sample, using additive ( P =0.0327) and recessive ( P =0.0381) models.

While ACE was not within the top renal genes correlated with ACE2, it showed nominally significant positive association with ACE2 in both the discovery resource ( P = 0.0327) and TCGA ( P = 0.0032), consistent with previous studies. 27 Taken together, these data show that ACE2 is a highly abundant kidney gene with a cell-type-specific pattern of expression in the proximal tubule and functional overlap with metabolic processes of key relevance to human health and disease.

In previous bacterial case–control comparisons, 32 34 there was a nominally significant negative association between Bacteroides intestinalis and SLE (effect size = −0.412, P = 0.033), although the association was not significant for RA (effect size = 0.056, P = 0.76).

A nominally significant ROC curve (p = .033) was obtained for this combination (Figure 1 ).

Comparing MDD-SI and MDD-nSI, nominally significant group × time interactions were observed for the λ ( F = 4.530, p = 0.033; β = 0.725, 95% CI: 0.049 to 1.400), and nodal efficiency exhibited a nominally significant group × time interaction in the right posterior cingulate gyrus ( F = 3.958, p = 0.046; β = -0.783, 95% CI: -1.565 to -0.003).

Pre-gestational DM showed a nominally significant inverse association (OR 0.32; 95% CI 0.11–0.91; p = 0.033); however, this result should be interpreted with caution given the very small number of pre-gestational DM cases ( n = 22 total).

Similarly, rs3835072 showed the most significant multivariate association with the different PD endophenotypes tested ( p = 1.88 × 10 −6 ), supported by a nominally significant effect on UPDRS ( p = 0.033, β (SE) = −0.038 (0.017)], in addition to the one detected with MoCA.

Moreover, we found nominally significant effects (uncorrected) of PAE for FA in the ICP-R (p = 0.033) and SS-L (p = 0.021).

The IVW estimate for fasting glucose was only nominally significant for both FVC and FEV 1 (p=0.033 and 0.023, respectively), with relatively wide confidence intervals to approach zero, and thus, the estimate should be treated with appropriate caution.

In contrast, cognitive function demonstrated a nominally significant moderating effect ( p = 0.033, adjusted R2= 33.09%; Fig. 3 D).

We observed nominally significant overlap (hypergeometric p = 0.033, Odds ratio = 1.4) between age effects on mRNA and age effects on DNAm levels at these genes.

Analysis of the allelic distribution among patients according to their asthma severity also indicated nominally significant associations of allele A of IL-4Rα A1199>C, allele T of IL-4Rα T1570>C and allele A of TNFα TNFα C-863>A with asthma severity (p = 0.033, p = 0.018 and p = 0.047, respectively).

The results showed the same trend for increased right-hand skill in carriers of the minor allele; the association was nominally significant with rs11855415 ( P = 0.033, β = 0.19, Table 1 ), but did not meet significance for rs9806256.

Association of the TOMM40 -L or APOE -ε4 with PDD compared with combined NC/PDnD group was only nominally significant ( P value = .033, P value = .024) and did not survive the correction for multiple testing.

Nominally significant association was found between SPON1 and Ecc_global ( P = 0.034).

There was a nominally significant change in the LSN ( p = 0.034), but it did not meet the corrected experimentwise critical alpha level (α = 0.006).

Among the remaining 13 common variant candidates, only one SNP (rs3774275; MASP1 ) was nominally significant in phase II ( p = 0.0340, Table 2 ), showing the same direction of effects as in phase I.

In fact, rs216013 is the only CACNA1C SNP in the PheWAS catalog results, and the catalog reports nominally significant evidence for association of this SNP with cardiac dysrhythmias ( P =0.034).

The set of 37 monogenic obesity genes showed a weaker but also nominally significant enrichment (2.05-fold enrichment, P = 0.034).