“nominally significant”

Knockdown efficiency was only nominally significant for shox ( p = 0.0284; q = 0.0635).

In an additional Model 4, we show that adding COPD to the model did not change the effect of rs7937 on DNA methylation ( Supplementary Material , Table S1). COPD and FEV 1 /FVC analyses When testing for association of DNA methylation at the four replicated differentially methylated CpG sites with COPD, we observed a significant association with cg11298343 ( EGLN2 ) in Model 1 [ β (SE)=−7.080 (2.16), P = 0.001] ( Table 3 , Supplementary Material , Table S2), which remained nominally significant with diminished but still strong and concordant negative effect, after adjusting for smoking [Model 2; β (SE) = −4.924 (2.25), P = 0.029].

Age and sex adjusted MaAslin model indicated that Fusobacteria was nominally significant ( p = 0.029 ) with beta 0.685 (se 0.33) but multiple testing corrections turned to null ( q = 0.309 ) (Supplementary Table 5 ).

This means that the effect of high RLE score on either BSI-DEP or BSI-ANX was in average 4 times higher in TT compared to CC genotype individuals. The rs3219151xRLE interaction effect was nominally significant on DEP (p = 0.029, FDR-q = 0.077) and showed a trend on SUIC (p = 0.093, FDR-q = 0.186) but none of them survived correction for multiple testing.

The effect of xanthurenate on eGFR was nominally significant (effect estimate = − 0.0086; p = 2.9e−02).

Brexpiprazole was associated with nominally significant improvements in ZAN-BPD total score versus placebo at Week 8 (LSMD −1.88; 95% CLs −3.57, −0.19; p = 0.029) and Week 12 (LSMD −2.30; 95% CLs −4.04, −0.55; p = 0.010).

The variant rs2954029 that originally associated with blood TG levels was only nominally significant here ( P =0.029, β =−0.29).

Kaplan–Meier analysis revealed a nominally significant lower risk of HF hospitalization with finerenone therapy at 1 year (HR 0.81; 95% CI: 0.66 to 0.99; log-rank p = 0.029), which was not robust after adjustment for multiple comparisons ( Table 2 and Figure 9 ).

However, MVMR was suggestive of a nominally significant causal association between genetically susceptible CHB and severe COVID-19 (OR = 1.12, 95% CI 1.01–1.23, P = 0.029) (Table 3 ).

Notably, MR-Egger analysis revealed a nominally significant causal relationship between AD and ALS (OR = 1.079, 95% confidence interval : 1.017–1.145, P = .029), as well as between PD and ALS (OR = 1.210, 95% confidence interval: 1.046–1.401, P = .020). 3.3.

There is nominally significant evidence that the -1131T>C variant is having an effect on maternal height (164.9 cm (164.3 – 165.5) to 167.0 cm (165.2 – 168.8), p = 0.029).

However, this association was only nominally significant in the meta-analysis combining the discovery and replication cohorts (p = 0.029 for model 2).

The HTR3D variant rs1000592 (p.H52R) demonstrated a nominally significant association with OCD in case-control analysis ( p =0.029), which remained significant in combined case-control and trio analyses ( p =0.024).

Only the sleep duration × education interaction was nominally significant ( p = 0.029) ( Supplementary Tables S6 ).

Four of these SNPs were replicated in the current GWAS (Model A) with nominally significant P ‐values: rs17125944 in FERMT2 (C‐allele: OR = 1.22, P = 0.029), rs3865444 in CD33 (A‐allele: OR = 0.87, P = 0.008), rs10838725 in CELF1 (C‐allele: OR = 1.14, P = 0.019), and rs10498633 in the SLC24A4 ‐ RIN3 region (T‐allele: OR = 0.88, P = 0.045).

There was also a nominally significant reduction in climbing success on knockdown of CG32549 using the ACT5C promoter (UAS = 90.6% ± 9.7%, UAS-KD = 77.7% ± 13.4%, t test: t 17 = 2.4, p = .029, n = 10 per condition on average, Bonferroni (adjusted for three comparisons) p > .05).

The associations were nominally significant in the total sample (1.03 [1.00–1.07], p = .029) and in participants with a single MDD diagnostic record (1.04 [1.00–1.08], p = .031), with similar directions of association ( Figure 3 and Table S11 ).

Among the subjects with low coffee consumption, only one association remained nominally significant (cg14476101, P = 0.03).

We also observed higher insulin levels in LoF heterozygotes and homozygotes in the first 30 min of the test (β=0.59, p =2.6×10 –3 ) and a nominally significant trend toward elevated insulin levels throughout (β=0.34, p =0.03).

For secondary outcomes Sativex was associated with a nominally significant improvement in hyperactivity/impulsivity (p=0.03) and a cognitive measure of inhibition (p=0.05), and a trend towards improvement for inattention (p=0.10) and EL (p=0.11).

Although the direction and magnitude of association for 8 SNPs (at the UMOD, GCKR , PIP5K1B , PRKAG2 , STC1 , VEGFA , SHROOM3 , and ALMS1/NAT8 loci) were consistent with our previous findings for eGFR and prevalent CKD [16] , [17] , only two SNPs showed nominally significant associations with ESRD ( Table 2 ): rs1260326 in GCKR (OR = 0.93; p-value = 0.03) and rs12917707 in UMOD (OR = 0.92; p-value = 0.04).

Secondary testing of ApoE-ε4 carriers against noncarriers within the group of subjects with declined memory indicated a nominally significant difference in the percentage of positive weights between groups (Roy’s maximum root F(9,8) = 5.29, p < 0.03).

Look-ups in consortium data showed a nominally significant association for the leptin-decreasing allele of rs10487505 with higher BMI in the GIANT Consortium ( P =0.03, N =221,677), as well as with increased risk of early-onset obesity ( P =0.04, N =13,848) and higher birth weight ( P =0.02, N =26,836) in the EGG Consortium ( Supplementary Table 7 ).

We also found nominally significant discrimination of unaffected siblings from healthy controls based on successful stop activation maps (AUC = 0.59, p < 0.030, 95% Modified Wald CI: 0.52–0.66 AUC) as well as nominally significant discrimination between participants with ADHD and healthy controls based on failed stop activation maps (AUC = 0.60, p < 0.019, 95% Modified Wald CI: 0.54–0.66 AUC, Fig. 1 ; for balanced accuracy, sensitivity and specificity measures in the complete and matched sample see Supplementary Table 2 ).

Examining males and females separately, a case-control analysis indicated that rs2144025 was nominally significant for the presence of bipolar disorder in females in a recessive model (p = 0.03) (Tables 3 & 4 ), but not in males.