“nominally significant”

In gene set analysis, we observed a nominally significant enrichment of rare exonic CNVs in synaptic signaling in ED patients (odds ratio = 2.55, P = 0.0254).

In the study that assessed the single-inhaler triple therapy GLY/FOR/B (KRONOS), triple therapy resulted in nominally significant improvements in SGRQ total score over 24 weeks compared with LAMA/LABA (difference: –1.22; 95% CI: − 2.30, − 0.15; p = 0.0259), but not LAMA/ICS (difference: –0.45; 95% CI: − 1.78, 0.87; p = 0.5036) [ 26 ].

Sex-specific analysis indicated that the association was nominally significant in women [OR = 4.31 [95% CI, 1.19–15.6], P = 0.026, FDR-corrected P = 0.112] rather than in men [OR = 2.16 [95% CI, 0.77–6.11], P = 0.145, FDR-corrected P = 0.305]; however, the difference by sex was not significant ( P difference = 0.41).

The only nominally significant time × group interaction was observed for the nurse role domain, F(1, 74)=5.130, p=0.026, ηp2=0.065.

Interestingly, in a meta‐analysis including 11 359 patients receiving therapy within 16 h of admission for acute heart failure in the serelaxin development program, serelaxin was associated with a nominally significant 13% reduction in all‐cause mortality (95% CI 0.77–0.98; p = 0.026). 10 In this current substudy, serelaxin treatment was associated with a 45% reduction in in‐hospital worsening heart failure.

A nominally significant association was identified with the [SL+SS] genotype of SLC6A4 and cocaine KMSK scores ≥“cutpoint” for a cocaine dependence diagnosis ( p =0.026).

The EWAS reported four novel loci in Europeans: rs62621812 ( p = 8.2 × 10 −8 , after adjusting for BMI p = 2.8 × 10 −12 , ZNF800 , missense), rs379926 ( p = 3.8 × 10 −3 , after adjusting for BMI p = 3.8 × 10 −6 , KLHL31 , missense), rs972283 ( p = 1.1 × 10 −10 , after adjusting for BMI p = 3.8 × 10 −18 , KLF14 , intergenic), and rs2340550 (only nominally significant after adjusting for BMI p = 2.6 × 10 −02 , ACTL9 , missense; not included in MR).

Although the Kruskal–Wallis test indicated a nominally significant difference in waist circumference ( p = 0.026), none of the pairwise comparisons remained significant after Bonferroni correction for multiple testing: Canola vs.

Interestingly, we also found a nominally significant association (p=0.026) between age-at-menopause and DNAmTLadjAge.

Of the six biomarker measures, only the number of astrocyte-derived MV (GFAP) showed a nominally significant correlation with PiB SUVr in unadjusted analysis (Spearman r s = 0.27, p = 0.026).

Nominally significant associations were observed for NKG2C+ B cells ( p = 0.026) in the overall sample.

This association was nominally significant in another cohort (ID: ebi-a-GCST004988; IVW P = 0.026).

Similarly, the CR gene KMT2D met the criteria for statistical significance (p = 0.0087), while two others ( KDM6A and SMARCA4 ) were nominally significant (p = 0.026 and 0.032, respectively) (Figure 4 C, Table S2 ).

The lowest p -value was found for a negative age-by-A1 orth interaction effect on the nucleus accumbens (beta = −0.410, p = 0.004, p FDR = 0.017), followed by a trend positive correlation with A1 orth (beta=0.346, p = 0.015, p FDR = 0.058) and a nominally significant A1 orth -by-A2-association (beta = −0.082, p = 0.026, p FDR = 0.104) (Table 1 ).

However, as shown in Table 1 and Figure 1 , some nominally significant positive causality correlations with OA did not pass multiple-testing correction for the Bonferroni method (hip OA: OR = 0.76, 95% CI: 0.51–1.00, P = 2.65 × 10 −2 ; knee OA: OR = 0.81, 95% CI: 0.63–0.98, P = 1.57 × 10 −2 ).

We identified 18 distinct MAPT H1 subhaplotypes, among which H1j displayed a nominally significant reduced risk of PSP (OR, 0.201; 95% CI, 0.044–0.915; p = 0.0265).

Our results for MCP-3, SCF and CXCL9 did not replicate in the Finnish population (P > 0.05 in the Finnish cohort for our top SNVs) and our result for TNFB was only nominally significant (P = 0.027).

Only the ATM gene exhibited a nominally significant association ( p = 0.027), with the direction of the rare variant burden being higher in cases compared to controls, providing some statistical support for the DNA repair model.

For example, while GDNF and GPR15 expression data did not pass QC filtering, GNG12 expression was successfully measured and displayed a modest and nominally significant inverse correlation with GNG12 cg25189904 (r = −0.143, p = 0.027).

Potential mediation was further supported by the finding that the overall interaction effect was only borderline significant after addition of these risk factors (model 6 versus model 5, P = 0.062 ( Table 3 )), although the interaction effect of the WGS with low versus high EA was not attenuated and remained nominally significant (model 6, B = −0.034 (SE, 0.015); P = 0.027) (Web Table 1).

There was a nominally significant association between endothelial cell loss and APOE ε4 homozygous genotype ( b = −9.6 × 10 −2 , SE = 4.3 × 10 −2 , P = 2.7 × 10 −2 ), which remained when restricting to only controls ( b = −9.9 × 10 −2 , SE = 4.7 × 10 −2 , P = 4.3 × 10 −2 ; n = 511), adjusting for baseline covariates.

We found two potential candidate genes with nominally significant cis-eQTL effects, PCDH7 ( P = 0.027, distance from the rs6448771 250 kb) and CCKAR ( P = 0.017, distance from the SNP 4.9 Mb).

PSC In accordance with the cis-pQTL definition, a nominally significant association was observed between genetically predicted C8G (IVW, OR: 0.832, 95% CI 0.707–0.979; P =0.027) and CFHR5 (IVW, OR: 1.193, 95% CI 1.048–1.357; P =0.007) in relation to the risk of PSC ( Fig. 2 ).

In PSP, we observed a nominally significant enrichment in oligodendrocyte enhancer sequences ( P = 0.027) (Fig. 1b ).

IgM had an estimate similar to that previously stated (β=−0.232) and showed a nominally significant p -value ( p = 0.027).