“nominally significant”

For SRT50 F2IC, the global time effect was nominally significant ( p = 0.024), but did not remain significant after FDR correction (q = 0.072), and should therefore be interpreted cautiously.

During observation, nominally significant uncorrected effects were observed only in bilateral IFG (left IFG: hand − dot = − 0.142, 95% CI [− 0.263, − 0.021], p = 0.024, dz = − 0.49; right IFG: hand − dot = − 0.133, 95% CI [− 0.265, − 0.001], p = 0.049, dz = − 0.42), but these effects did not survive correction for multiple comparisons and were therefore treated as exploratory.

Subjects with asthma/allergic diseases had lower post-vaccination HAI titer for H3N2 strain than the rest of the vaccinees, which was nominally significant (β = −0.167, P = 0.024).

Similar to the comparison between binge drinkers and non-binge drinkers, a nominally significant genetic effect was identified for maternal variant rs869978 for binge drinkers versus non-drinkers (p = 0.0242).

Efficacy end points in the ITT population Primary end point The difference in the average slope of change in 6MWD over 72 weeks between the ataluren and placebo groups was nominally significant (-0.74 m/week and -0.94 m/week in the ataluren and placebo groups, respectively; difference [95% CI]: 0.20 [0.03, 0.38]; p = 0.0248), equivalent to a 21% slower rate of decline in the ataluren group ( Table 3 ).

There were no other significant effects although Q2.1 had a nominally significant ( p < 0.025) additive effect in a WW background and Q7.2 had a nominally significant additive effect in an EW background ( Fig 3D and 3I ).

We found nominally significant polygenic enrichment of associations with college completion (p = 0.025), educational attainment (p = 0.043) and general cognitive ability (p = 0.015 and 0.025, respectively), suggesting that variants influencing these phenotypes are more prevalent in evolutionarily salient regions.

Haplotype analyses of the CRHR1 gene in 2,533 unrelated Caucasian individuals identified one haplotype in the proximal block 1 and two haplotypes in the distal block 2 that showed nominally significant genotype – traumatic stress interactive effects on the likelihood of developing alcoholism (corrected P<0.025) ( 32 ).

In the replication analysis (254,532 individuals) dog exposure × rs10214237 (on chromosome 5p13.2 near IL7R ) was nominally significant (OR interaction = 0.91 [0.83–0.99] p = 0.025), with a risk effect of the T allele observed only in those not exposed to dogs.

The null distribution was generated by recording the maximum CFE statistics at each of the 5000 permutations and a fixel is considered nominally significant if the whole-brain two-tailed family-wise error (FWE) corrected p-value < 0.025 (0.05/2).

The two co-primary endpoints were tested without multiple-comparison correction, given pre-specified hypotheses with separate rationales; the four-pattern and surgery-level AKI models were treated as exploratory, so the nominally significant GA–SA contrast ( p = 0.025) carries no confirmatory status.

Although no significant genetic loci were found in this analysis and only one of our Resilience genetic loci was nominally significant in the HRS GWAS (chromosome 3 locus; p = 0.025), there was a significant genetic correlation ( r g = −0.65, p = 1.5 × 10 −3 ) between cognitive change and Resilience .

Adjustment Disorders, Autism Spectrum Disorders, and Attention-Deficit/Hyperactivity Disorder For autism spectrum disorders, a nominally significant association was observed in Cohort 3 (HR 4.84, 95% CI 1.04–22.44; p = 0.025); however, this finding must be interpreted with extreme caution for multiple reasons: (1) very low absolute event counts (fewer than 10 per group); (2) wide confidence intervals reflecting statistical instability; (3) new ASD diagnoses in adults likely represent delayed recognition or diagnostic re-evaluation rather than true incident neurodevelopmental disease; and (4) the biological plausibility of a treatment effect on ASD within a 24-month window is limited.

Among iCMS2 tumours, aflibercept was associated with numerically improved outcomes without reaching statistical significance, whereas iCMS3 tumours exhibited a nominally significant PFS benefit (HR 0.66, p = 0.025), but this did not withstand FDR correction ( q = 0.100) and was not accompanied by an OS benefit.

A simultaneous cross-channel association analysis across all five channels finds that 19 of 20 pairwise Spearman correlations are non-significant; the single nominally significant result (pupil–duration, ρ = + 0.697 , p = 0.025 ) does not survive Bonferroni correction and is not robust to outlier removal.

For all-cause death, the intensive BP treatment × TyG interaction was nominally significant ( P = 0.025), whereas intensive BP treatment × CKM stage ( P = 0.230), intensive BP treatment × CKM stage × TyG ( P = 0.775), and the joint interaction test ( P = 0.116) were not significant.

Evaluating a total of 134 ATP1A2 polymorphisms genotyped using a combination of Illumina platforms (Cardiovascular Gene-centric 50 K SNP Array and HumanOmni1-Quad_v1-0_B Bead Chip), only one polymorphism ( rs2070704 ) demonstrated a nominally significant association with stroke in an age-, gender-, ethnicity-adjusted model (OR = 0.83, 95% CI = 0.71-0.98, p = 0.025) and in a vascular risk factor model adjusting for age, gender, ethnicity, hypertension, diabetes, smoking, and myocardial infarction (OR = 0.74, 95% CI = 0.63-0.89, p = 0.001).

A nominally significant causal relationship was observed between CIR and EBV ZEBRA antibody levels (OR = 1.082, 95% CI: 1.009–1.161, P = 0.025).

Nominally significant associations were observed for female height at 1 month ( r = −0.272, p = 0.025) and male height at 36–48 months ( r = −0.225, p = 0.042), but neither remained significant after Bonferroni correction (adjusted significance threshold p < 0.005).

Two of the four ( DNM2 ∼ LDL and TARS2 ∼ height) gene-trait pairs were replicated (beta = −0.203, SE = 0.089, p = 0.012 and beta = 0.053, SE = 0.018, p = 0.001 from the burden test, respectively) after multiple testing adjustment and another association ( ACAN -height) was nominally significant (beta = −0.094, SE = 0.045, p = 0.025 from the burden test).

The meta-analysis of the replication cohorts, where the variant was present, was nominally significant and showed a consistent direction of effect with the discovery sample (OR 1.18 [95% CI 1.02, 1.36], p =0.025) (Fig. 3 c, ESM Table 5 ).

meQTL analysis After meta-analysis, a SNP (rs2611513) mapped to PRKG1 was nominally significant in association with methylation patterns of cg17426237 at PARG ( n = 141, p = 0.025; Fig. 4A ).

In the fully adjusted model (M3), the lower risk of developing adjudicated dementia associated with large CHIP (VAF ≥ 8%) was nominally significant (M3 HR = 0.62, 95% CI: 0.41 to 0.94, p = 0.025).

In the secondary analysis, we found a nominally significant causal association between zinc and osteomyelitis (OR = 1.13, 95%CI = 1.02 to 1.27; p = 0.0252) and a strong causal association between vitamin B6 and osteomyelitis in the secondary analysis (OR = 2.78, OR 95%CI = 1.34 to 5.76; p = 0.0060).

The additive model showed a nominally significant effect for CDT ( β = 0.2959, p = 0.0252), while no significant associations were observed under the dominant or overdominant models ( Supplementary Table S5 ).