“nominally significant”

While five gene sets (including DNA helicase) were nominally significant (4.8 × 10 −3 ≤ P ≤2.1 × 10 −2 , Supplementary Table 5 ) these gene sets were not significant after multiple comparison correction (false discovery rate >0.10).

A nominally significant interaction effect between ADHD and sex was noted, p = 0.021.

Results We observed nominally significant single-marker associations with schizophrenia in SNP2 ( P = 0.021) and SNP3 ( P = 0.029) of SLC1A4 , SNP1 ( P = 0.009) and SNP2 ( P = 0.022) of SLC6A5 .

MR estimates were directionally consistent across methods, with nominally significant associations under IVW (OR ≈ 1.001; 95% CI ∼1.000–1.002; p ≈ 0.021) and weighted median (OR ≈ 1.0009; 95% CI ∼1.0002–1.0017; p ≈ 0.011), whereas MR-Egger and weighted mode were not significant ( Figure 3B , Supplementary File 2 ).

This association remained nominally significant after adjustment for maternal age at first delivery (adjusted β = −0.2679 weeks, 95% CI: −0.4948 to −0.0410, p = 0.021).

Following permutation testing, the only nominally significant microRNAs were hsa-let-7b-3p ( P = .021) and hsa-miR-130b-3p ( P = .045), albeit neither was significant after Bonferroni correction ( P = .082 and P = .18, respectively).

Results We observed a nominally significant association of the IL1β rs1143623 C allele with the risk for Parkinson’s disease ( OR = 0.59; 95%CI = 0.38–0.92, p = 0.021).

The analysis revealed a nominally significant association between treatment modality and the timeframe for apical closure ( P = .021).

PRS-Diet Effects on PA and Weight Change Regarding PA outcomes (MET-mins/week), PGS002255 (HRC panel) showed a nominally significant negative association at the end of month 1 (Β = −3.73 × 10 7 , p = 0.021) ( Table 2 ), indicating that individuals with higher genetic risk scores were less likely to increase their activity levels during the early phase of the intervention.

Nominally significant differences were observed only for gender (72% males in SUDEP group versus 41% in living epilepsy controls, P = 0.021) and convulsive seizures in the 12-month period before last follow-up or death (present in 72% of SUDEP cases versus 42% of living epilepsy controls, P = 0.021).

Analyses within T2-high and T2-low subgroups showed nominally significant uncorrected correlations (e.g., HDL-C with MMEF% in T2-high: ρ = 0.425, p = 0.021; HDL-C with PEF% in T2-low: ρ = 0.362, p = 0.035), but none survived FDR correction (all FDR-p > 0.37).

The first ancestry PC showed a nominally significant association ( P = 0.021) to small CNV burden (autosomal <100 kb CNV burden) and was included as a covariate.

The association was nominally significant (p = 0.021) but did not withstand the Bonferroni correction for multiple testing ( Table 3 ).

The GG haplotype in the second block of ADRB2 showed a nominally significant association with uncontrolled asthma ( P =0.021).

The association between genetically proxied GLP1RA using 6 SNPs as the instrument and decreased risk of ileus was nominally significant (IVW: P = 2.11 × 10 −2 ; weighted median: P = 1.86 × 10 −2 ; weighted mode: P = 7.80 × 10 −2 ; simple mode: P = 1.57 × 10 -1 ) (Fig. 3 , Table S1, Supplemental Digital Content, https://links.lww.com/MD/R558 ).

As shown in Table 3 and Table 4 , the group effect for Conscientiousness and the genotype × group interaction for Extraversion remained significant under the Bonferroni-adjusted family-wise threshold (α = 0.01), whereas the main genotype effect for Agreeableness was only nominally significant ( p = 0.0216) and should be interpreted cautiously. 4.1.

Similarly to the DRG eQTL analysis, the representative SNP rs13078961 was associated with MRAS mRNA expression at the exon level with a similar pattern in males and females combined (beta = −0.21, P = 3.76 × 10 −2 ), and nominally significant only in males in a sex-stratified analysis (beta = −0.39, P = 2.17 × 10 −2 ) (Supplementary Table 8, available at http://links.lww.com/PAIN/A688 ).

Firmicutes showed a nominally significant increase (median Δ = 0.124, V = 49, p = 0.022); however, this effect did not remain significant after correction for multiple testing (Holm-adjusted p = 0.087).

MRI sample Subcortical structures We found nominally significant associations between TG seropositivity and right thalamus, F(1,408) = 5.258, p = 0.022, η 2 = 0.013, and left nucleus accumbens, F(1,408) = 4.317, p = 0.038, η 2 = 0.010, among SMI patients with smaller volumes in TG+ than TG– patients (Table 2 & Fig. 3 ).

Three of the compared definitions showed a nominally significant association between dry skin and keratoconus ( P = 0.022, P = 0.012 and P = 0.004), with the remaining definitions showing concordant effect direction.

However, the difference are only nominally significant ( p = 0.022) before multiple testing correction for the 11 ACR criteria tested.

The association between “unclassified_Bacteria” and RF positivity was nominally significant (Mann-Whitney U test, P = 0.022, Supplementary Table 5 ), though it did not remain significant after FDR correction ( q = 0.391).

In both univariate and multivariate analyses, nominally significant associations were found among body mass index (OR, 3.14; 95% CI, 8.5338 to 1.1274; p=0.022), breast size (OR, 5.11; 95% CI, 17.04 to 1.54; p=0.004), and grade ≥ 2 acute radiation skin toxicity.

reported nominally significant associations between rs667282 and CPD in a study of 3 725 smokers in a Chinese population ( P = 0.022) [14] .

In the ITT population, the active group was relatively stable or showed a slight improvement (37.45 ± 11.31 to 37.96 ± 10.78; mean Δ +0.51), whereas the sham group exhibited a decline (35.23 ± 13.15 to 32.91 ± 14.00; mean Δ −2.32), yielding a nominally significant between-group difference in change ( p = 0.022; Table 2 ).