“nominally significant”

We observed nominally significant genetic correlation between BAG and AD that did not survive FDR-correction ( r = 0.23, SE = 0.1, p = 0.02, FDR adjusted p = 0.13) and no significant associations with any other of the four disorders (Fig. 2a ).

Oxoadipate and threonine also showed nominally significant time-by-group interactions (p = 0.02 and p = 0.03, respectively), though these did not remain significant after FDR correction ( Supplementary Table 4 ).

However, for colorectal cancer, two SNPs, rs12794714 (CYP2R1) and rs10741657 (CYP2R1) had nominally significant associations (HR (95% CI), p -values-rs12794714: 1.21 (1.03–1.41), p = 0.02 and rs10741657: 1.22 (1.05–1.43), p = 0.01).

A nominally significant difference in SLAMF7 gene expression ( P = 0.02) was detected where current smokers had reduced levels of expression of SLAMF7 .

However, the module “greenyellow” showed a nominally significant positive correlation with outcome (unadjusted P ‐value = 0.02, FDR adjusted P ‐value = 0.14) and a negative significant correlation with both 5‐MeTHF (FDR adjusted P ‐value = 0.02) and folic acid levels (FDR adjusted P ‐value = 0.02) (Figs. 2A and 3A,B ; Figs.

We further investigated the psoriasis/CAD genetic correlation by applying LDSC to our case-control psoriasis GWAS (11,024 cases and 16,336 controls) and a large CAD GWAS (60,801 cases and 123,504 controls), which provided a nominally significant ( p = 0.02) genetic correlation ( r g = 0.11).

0.6, p =0.005) and remained nominally significant in the NHW group (AF=0.33 vs. 0.6, p =0.02) (Supplemental Table S9, http://links.lww.com/HC9/B26 ).

In head and neck squamous cell carcinoma, ROH was not significantly associated with cancer risk for females but was nominally significant for males ( p = 0.02 ) .

Similar to meta-analysis in the three new cohorts, traditional random effects meta-analysis was only nominally significant (β = 0.12, P = 0.02), but highly significant based on the Han/Eskin model ( P = 6.89 × 10 −8 ) ( Table 3 ).

Hsa_circ_0002564 shows weak correlations with the other two circ PSEN1 species even though some of them are nominally significant (with hsa_circ_0008521 only in the discovery dataset—r 2 = 0.25, p = 0.02, and with hsa_circ_0003848 in the discovery—r 2 = 0.26, p = 0.01 and in the BM22 of the MSBB dataset—r 2 = 0.31, p = 8.15 × 10 –05 ).

The association was only nominally significant (P = 0.02), indicating that the rs200573126 variant is driving the association.

For the third approach using the correlation between expression and DNA methylation, 4 genes showed a nominally significant correlation between expression and methylation: AES (Spearman rho=-0.54, p =0.02), SAR1A (Spearman rho=0.50, p =0.03), CRYBG2 (Spearman rho=0.47, p =0.04), and S1PR4 (Spearman rho=-0.48, pval=0.04).

We found a nominally significant association between BMI and GVFL ( p = 0.02) and BMI and GON ( p = 0.01), which were not significant after correction for multiple testing.

Although no proteins were significantly replicated in ARIC Black participants, KDR showed a nominally significant association ( p = 0.02) with the same direction of association as the discovery result.

The Counterintuitive Survival Finding: A Statistical Artifact The nominally significant association between BAP1 loss and longer DFS (log-rank p = 0.020) directly contradicts the extensive literature establishing BAP1 loss as an adverse prognostic marker [ 11 , 12 , 13 , 14 , 15 , 16 , 17 ].

The allelic effect on CXorf21 expression was only nominally significant when performing the cis -eQTL analyses in female individuals from Geuvadis RNA-Seq dataset in LCLs ( P = 0.02; linear-regression; Supplementary Fig. 2a ).

I could only find one cancer type (GBM) where mutations in TP53 are associated with a nominally significant increased age acceleration (p = 0.02)". as follows: TP53 mutation is associated with significantly lower age acceleration in six data sets (Additional file 6 ) including AML (P = 0.0041), breast cancer (P = 7.8×10 −12 and P = 1.4×10 −12 ), ovarian cancer (P = 0.04), uterine corpus endometrioid (P = 0.0012), and colorectal cancer (P = 0.036, Figure 4 B).

For NT discordance, a nominally significant interaction term was identified ( p = 0.020); however, this result should be interpreted with caution given the small number of NT-positive MCDA cases ( n = 3) and model non-convergence, precluding reliable subgroup-specific estimates.

Other nominally significant associations include HDL (r g =0.14, P=0.02) and current/former smoking status (r g =0.20, P=0.04) both of which are supported by epidemiological observations 16 .

As expected, when included simultaneously in the Cox model, associations of both metabolites were weaker but remained nominally significant for hexadecanedioate (model 1: HR [95% CI] 1.22 [1.04; 1.44], p = 0.02; model 2: HR [95% CI] 1.14 [1.00; 1.39], p = 0.09) but not tetradecanedioate (model 1: HR [95% CI] 0.93 [0.80–1.08], p = 0.35; model 2: HR [95% CI] 0.98 [0.81; 1.17], p = 0.80).

There was a nominally significant sex difference for the audio–visual condition only ( P = 0.02).

This single variant accounted for 76% of loss of function carriers and the CHEK2 association was nominally significant when it was excluded ( p = 0.02, effect = 0.18 SD).

The association with T2D was nominally significant but did not survive Bonferroni correction (OR = 1.44, 95% CI 1.06–1.96, p = 0.0201).

Influence of Age on Expression Levels of Interferon-Stimulated Genes in Female Participants In the female subset, age showed two modest but nominally significant associations with ISG expression: IFI44L decreased with age (r = −0.3556; p = 0.0208) and IFI27 increased with age (r = 0.3415; p = 0.0289).

When the factor loadings were forced to be invariant across the 3 nicotine doses, the change of χ 2 was insignificant for the positive factors (Δ χ 2 10.5, Δ DF 29, p = 0.9993), and the change of χ 2 was nominally significant (Δ χ 2 32.2, Δ DF 18, p = 0.0208) for the negative factors.