“nominally significant”

Table 3 shows that there was nominally significant evidence that ever use of HRT was associated with an increased risk of breast cancer among all women (OR 1.86; 95% CI 1.11 to 3.12; P = 0.02).

Specifically, plastic waste shows nominally significant positive correlation with paper or cardboard waste ( p -value = 0.02).

The allelic effect on CXorf21 expression was only nominally significant when performing the cis -eQTL analyses in female individuals from Geuvadis RNA-Seq dataset in LCLs ( P = 0.02; linear-regression; Supplementary Fig. 2a ).

Gene Set Analysis Primary Analysis of Voltage-Gated Sodium and Calcium Channels We found nominally significant evidence for enrichment in cases for LoF variants (frequency <0.1%) in voltage-gated sodium channels (targeted sequencing sample: OR, 1.99; 95% CI, 1.11–3.71; p = .02; p corrected = .08; case-control-de novo meta-analysis: p = .025; p corrected = .1) ( Table S4 in Supplement 2 ), but no evidence for association between schizophrenia and voltage-gated calcium channels ( Table S4 in Supplement 2 ).

Three further SNPs demonstrated nominally significant associations with preeclampsia: the intergenic SNP rs17249754 located just downstream of the ATPase, Ca 2+ transporting, plasma membrane 1 ( ATP2B1 ) gene ( P = 0.02, OR 0.80, CI 95% 0.66–0.97), the intronic SNP rs16933812 in the paired box 5 ( PAX5 ) gene ( P = 0.04, OR 0.85, CI 95% 0.74–0.99), and the intronic SNP rs12946454, located in the phospholipase C delta 3 gene ( PLCD3 ) ( P = 0.046, OR 0.85, CI 95% 0.73–0.80).

I could only find one cancer type (GBM) where mutations in TP53 are associated with a nominally significant increased age acceleration (p = 0.02)". as follows: TP53 mutation is associated with significantly lower age acceleration in six data sets (Additional file 6 ) including AML (P = 0.0041), breast cancer (P = 7.8×10 −12 and P = 1.4×10 −12 ), ovarian cancer (P = 0.04), uterine corpus endometrioid (P = 0.0012), and colorectal cancer (P = 0.036, Figure 4 B).

Similar to meta-analysis in the three new cohorts, traditional random effects meta-analysis was only nominally significant (β = 0.12, P = 0.02), but highly significant based on the Han/Eskin model ( P = 6.89 × 10 −8 ) ( Table 3 ).

Rs16923760, which associates with AD risk in a Caribbean-Hispanic series (OR = 0.74) [6] , is in LD with rs4746648 (D’ = 1.0, r2 = 0.01) that has nominally significant AD risk association in our combined cohort (p = 0.02, OR = 0.86).

For cognitive aging, PRS SCZ was associated with lower MMSE (beta in per SD increase in PRS = -0.069, p = 0.003), while PRS BPD was nominally significant associated with higher MMSE (beta = 0.054, p = 0.020).

If we do a crude point estimate comparison at 15 years of the rates there is a nominally significant difference between the 2 groups ( p = 0.02).

There was a nominally significant sex difference for the audio–visual condition only ( P = 0.02).

However, an interaction between the COA class II CS1 SNP (rs28407950) and sex was nominally significant ( p =0.02) (Additional file 1 : Table S7), reflecting a nominally larger effect in females (OR=1.43 95% CI [1.35–1.51]) compared to males (OR=1.31 95% CI [1.25–1.37]) for this variant.

Their sex was a nominally significant covariate, before multiple testing correction (sex: P = 0.02; χ 2 = 5.4 on 1 d.f.; genotype: P = 1.5E‐5; χ 2 = 22.1 on 2 d.f.).

Prior to correction for multiple testing, 16 of 156 correlations were significant at the P < 0.05 level, but only a single correlation remained nominally significant after Holm–Bonferroni correction (SOD‐TAC, r = −0.28, P = 0.02.

One other marker ( FNDC3B rs4894796) was nominally significant in the replication stage (OR = 0.95, P = 0.02) and remained suggestively associated with POAG in the overall meta-analysis (OR = 0.93, P = 1.40 × 10 −5 ) (Fig. 1 C; Supplementary Material, Table S2 ).

For multiple pregnancy rate ( Supplementary Table S4 ), while the pooled estimate was nominally significant (OR = 1.26, 95% CI: 1.03-1.55, P = 0.02), exclusion of three studies (Liang, Mao, and Wang) rendered the association non-significant, with 95% CIs crossing the null in all three scenarios; the effect, while directionally consistent, is statistically fragile and dependent on a subset of studies, with persistent high heterogeneity (I2 range: 61.42%-78.35%) further limiting confidence.

Given that several atherosclerosis risk factors have been associated with AS 6 , 18 , 19 , we tested the novel AS variants for association with the traditional cardiovascular risk factors and observed a nominally significant association ( P < 0.02) between rs1830321 and systolic and diastolic blood pressure in Iceland (Supplementary Data 3 ) and in data from the UK Biobank ( https://biobankengine.stanford.edu/search# ).

We further investigated the psoriasis/CAD genetic correlation by applying LDSC to our case-control psoriasis GWAS (11,024 cases and 16,336 controls) and a large CAD GWAS (60,801 cases and 123,504 controls), which provided a nominally significant ( p = 0.02) genetic correlation ( r g = 0.11).

Notably, State 5 exhibited a nominally significant reduction in the hallucination‐present group ( d = 1.11, raw p = 0.020), though this did not survive FDR correction ( p FDR = 0.061).

Differences in convulsive seizure reduction between placebo and CBD emerged during titration and became nominally significant by Day 12 for CBD20 ( p = .02) and Day 13 for CBD10 ( p = .03).

The association with WC remained only nominally significant in stage 2 (P = 0.02) after adjustment for BMI.

Hsa_circ_0002564 shows weak correlations with the other two circ PSEN1 species even though some of them are nominally significant (with hsa_circ_0008521 only in the discovery dataset—r 2 = 0.25, p = 0.02, and with hsa_circ_0003848 in the discovery—r 2 = 0.26, p = 0.01 and in the BM22 of the MSBB dataset—r 2 = 0.31, p = 8.15 × 10 –05 ).

There were a few additional nominally significant negative correlations, which did not survive multiple testing correction: MDD and epilepsy ( r = −0.37, p = 0.02), MDD and ADHD ( r = −0.33, p = 0.004), SCZ and ADHD ( r = −0.32, p = 0.005), ADHD and epilepsy ( r = −0.36, p = 0.02), and a positive correlation between MDD and ASD ( r = 0.26, p = 0.02).

Moreover, rs9313619 remained genome-wide significant when conditioning on rs29784 (conditional P = 3.50 × 10 −8 ), while if conditioning on rs9313619, the previously reported top SNP rs29784 remained only nominally significant ( P = 0.02).

There was a nominally significant main effect for enhanced VASC in the higher-dose group ( t (36) =−2.48, P =0.02), HCQ ( t (36) =−2.75, P =0.009) and STAI ( t (36) =−2.48, P =0.01), indicating more craving and state anxiety due to cortisol administration for the higher-dose group.