“nominally significant”

Circulating HDL levels are reported to be associated with decreased AD risk, and we observed nominally significant and positive covariance with CSF Aβ42 (r g- =0.007, SE = 0.003, p = 1.96×10 −02 ) in our analysis, although this failed to pass the FDR-corrected significance threshold.

By adding the ADHD rating scale total score into the regression model, the case-control differences and diagnosis*sex effects seen in IC9 remained nominally significant ( p = 0.0198 and 0.000234, respectively).

SNP rs7412746 showed nominally significant association with blue versus non-blue eye colour ( P =0.02), fair versus non-fair hair colour ( P =0.01) and dark brown versus non-dark brown hair colour ( P =0.02), as well as borderline association with nevus count ( P =0.06).

17 Interestingly, a preliminary analysis focused on the expression of the SARS-CoV-2 receptors Ace2 and Tmprss2 revealed a nominally significant ( P = .02) inhibition of Ace2 expression in OM-85–treated mice compared with PBS-treated controls.

There was a nominally significant sex difference for the audio–visual condition only ( P = 0.02).

The IVW method indicated a nominally significant association between AS and non-endometrioid EC (OR = 1.05, P = 0.02), though MR-Egger and weighted median estimates were non-significant.

There was a nominally significant ( p = 0.02) difference between APOE ɛ4 carriers as compared with non-carriers in brainstem volume, which did not remain after FDR adjustment. 3.5.

When regressing alpha diversity measures against glycaemic traits, we found a nominally significant association ( P = 0.02) between the number of observed OTUs and beta cell function represented by the disposition index, but the association was insignificant at a 10% false discovery rate (FDR) ( Q = 0.2) (Additional file 1 : Figure S5).

MARCO had a strong and nominally significant correlation with paroxysmal pain (r = 0.48 95% CI [0.1, 0.76], P -value = 0.02).

0.22+0.15, p=0.09, t-test), which became nominally significant if one study with an outlying value in the control group 26 was excluded (0.31+0.18 vs. 0.20+0.11, p=0.02).

The association with rs11986220 was marginally stronger than rs10090154 in African Americans and when modeled concurrently in the pooled sample, rs11986220 remained nominally significant (OR, 1.39; 95% CI, 1.06–1.84; p = 0.02), whereas rs10090154 did not (p = 0.18), suggesting that rs11986220 better captures the effect of the functional allele at this locus (and may be the biologically relevant allele).

Given that there were strong positive correlations between the number of mutations of SBS1 and age at cancer diagnosis in breast cancer (Spearman’s ρ = 0.18, p = 2.50 × 10 −6 ), in colorectal cancer (Spearman’s ρ = 0.24, p = 2.85 × 10 −5 ), and in glioblastoma (Spearman’s ρ = 0.23, p = 1.11 × 10 −4 ); a nominally significant correlation between SBS1 and age in prostate cancer (Spearman’s ρ = 0.12, p = 0.02); and a significant correlation between SBS40 and age in endometrial cancer (Spearman’s ρ = 0.18, p = 9.67 × 10 −4 ), we further evaluated the associations of somatic mutations and PRS without adjusting for age at cancer diagnosis.

In the largest GWAS on nucleus accumbens volume, 7 this variant was nominally significant ( p = 0.02), showing the improved power of our current study to identify novel brain morphometry loci.

At day 45, the difference among the groups was nominally significant ( P = .02). 38 Post hoc analyses indicate that patients who received zuranolone experienced positive effects on insomnia symptoms and their overall functional health and well-being, as reported by the patients themselves. 40 , 41 Patients who participated in the ROBIN study were randomly assigned to receive either zuranolone 30 mg or placebo, both taken once daily with an evening meal for a duration of 14 days.

Although this difference in proportions was nominally significant (uncorrected P = 0.02), we did not see this effect in the equivalent analysis in the WGS cohort, where the proportion of HRCGS genes with more variants in ALS patients was indistinguishable from non-HRCGS genes (54% or 30 of 56 vs. 52% or 4,151 of 8,017, P = 0.089).

At an FDR of 10%, 34 of the 147 independent eQTL, highlighted in panel , show nominally significant interaction effects ( p < 0.02), implying different effect sizes in the two broad classes of disease.

Of these, 12 SNVs within TTN showed nominally significant (ie, P = .02 to .05) associations with late-onset CCM risk in the combined sample of European ancestry survivors, as shown in eTable 1 in Supplement 1 .

Notably, in contrast with the null causal estimates observed in the UVMR analysis, the BMI-adjusted hospitalized and severe phenotypes exhibited a nominally significant shortening of the QT interval [hospitalization: β BMI (95% CI): −0.45 (−0.82, 0.08), P =0.02; severe case: β BMI : −0.32 (−0.60,–0.03), P =0.03] ( Figure 4 ).

Similar to meta-analysis in the three new cohorts, traditional random effects meta-analysis was only nominally significant (β = 0.12, P = 0.02), but highly significant based on the Han/Eskin model ( P = 6.89 × 10 −8 ) ( Table 3 ).

In the postdocetaxel setting, the advantage of enzalutamide use was nominally significant for median PFS (1.2 months p = 0.02 without adjustment and 2.2 months and p = 0.0007 after adjustment); there was no significant difference in median OS between the two agents.

Notably, despite a nominally significant reverse association for palmitoyl dihydrosphingomyelin (OR = 1.06, P = .02), this isolated finding was considered non-significant after correction and was excluded from downstream pathway analysis (Fig. 3 ).

For NT discordance, a nominally significant interaction term was identified ( p = 0.020); however, this result should be interpreted with caution given the small number of NT-positive MCDA cases ( n = 3) and model non-convergence, precluding reliable subgroup-specific estimates.

The increased risk of breast cancer under the allele model, heterozygous model and dominant model was still nominally significant ( P =0.02, P =0.007, and P =0.01, respectively), which further confirmed the significant role played by ERCC1 rs11615 in breast cancer susceptibility.

The association was only nominally significant (P = 0.02), indicating that the rs200573126 variant is driving the association.

Gene Set Analysis Primary Analysis of Voltage-Gated Sodium and Calcium Channels We found nominally significant evidence for enrichment in cases for LoF variants (frequency <0.1%) in voltage-gated sodium channels (targeted sequencing sample: OR, 1.99; 95% CI, 1.11–3.71; p = .02; p corrected = .08; case-control-de novo meta-analysis: p = .025; p corrected = .1) ( Table S4 in Supplement 2 ), but no evidence for association between schizophrenia and voltage-gated calcium channels ( Table S4 in Supplement 2 ).