“nominally significant”

What is more, out of 208 associations that had 95% replication power (determined by sampling), 171 (82.2%) were replicated and 198 (95.2%) were nominally significant.

We identified multiple nominally significant epistatic interactions between the genes encoding KIR s and their HLA ligands on both the subtype and allele level, suggesting that AS risk, as likely the case for many immune-mediated diseases, is modified by a mosaic of genetic effects that converge to influence the proinflammatory capacity of KIR expressing lymphocytes.

Two-tailed p-values are presented with 0.05 designated as nominally significant.

Another nominally significant splice-QTL for the same SNP (rs9852988) was associated with a loss of exon 2 in the LPP transcript and showed high expression in the major allele (A).

Our analysis identified genome-wide significant association signals at 10 loci, and all previously reported MM lead variants were nominally significant with effects in the same direction as in the discovery studies (Supplementary Table 1 ).

In our own analysis of miRNA binding site over-representation among genes of the PFC green module, binding sites for both miR-30a (p = 0.003) and mmu - miR-1a/mmu-miR-206 (p = 0.04) showed nominally significant potential binding motifs among genes in the PFC green module using MiRvestigator Framework ( S15 Table ), suggesting that these miRNA families may be involved in regulation of green module genes beyond Bdnf alone.

Based on pre-specified multiplicity adjustment, patients treated with givinostat showed reduced worsening on NSAA when compared to placebo, which was nominally significant but not statistically significant.

Enrichment among nominally significant findings in our maternal early-pregnancy glucose concentrations was found for CpGs identified in a previous study on adult type 2 diabetes.

Individual genetic correlations were nominally significant at α = 0.05 (based on | r G |> 1.96SE) except those between body and abdomen mass and between body mass and female LRS.

Of the remaining eight single parent associations with six phenotypes (SBP, age of menarche, LDL-C, Total cholesterol, CIMT, FEV 1 ), only one SNP with FEV 1 was nominally significant ( p -value 0.0391; replication p -value threshold 0.003125 for 16 tests) in the Sardinians.

Analyzing the individual components of the primary outcome revealed a nominally significant reduction in the risk of dying from CV causes in the semaglutide group.

Pathways with a Fisher’s exact test p < 0.01 were considered nominally significant.

We found numerous nominally significant novel DMCs at or nearby 450K array-derived, widely replicated smoking-associated locations in or near GFI1 , ALPPL2 , AHRR , MYO1G , SLC24A3 , PPP1R15A ( GADD34 ), and F2RL3 genes (listed in Excel Table S5) and at previously unknown smoking-associated locations in or near HOXA5 , RDX , and LRP5 .

Sensitivity analyses excluding participants with comorbid alcohol or tobacco use disorders ( n = 13) revealed that the association between loss aversion and the number of GD criteria remained nominally significant, whereas the association with working memory did not (see Table S4 in the supplement).

For TOAST subtypes, nominally significant associations were present in the cardioembolic and small artery occlusion groups, though these comprised only 36 and 68 patients, respectively.

Using univariate non-parametric statistics, there were no differences regarding alpha or beta diversity between AH8.1 carriers (categories I and II) and non-carriers (categories III and IV), however four different taxa ( Prevotellaceae , Clostridium XVIII , Coprococcus , Enterorhabdus ) had nominally significant lower abundances in AH8.1 carriers than non-carriers.

We used an adjusted p ‐value < 0.1 to designate significance but also reported results with nominally significant p ‐values (< 0.05) as exploratory findings.

Nominally significant differences in relative abundance, not adjusted for multiple comparisons, were reported for six bacterial genera — two increased ( Enterococcus and Streptococcus ) and four decreased ( Bacteroides , Clostridium , Roseburia , and Eubacterium ) in CRA cases ( Chen et al., 2013 ).

Across the 3 cohorts all 21 proteins with nominally significant P-values show positive association with DKD progression ( Figure 1 ).

There was a nominally significant association between CUD and the SA of inferior temporal and posterior cingulate, as well as the TH of middle temporal (P ivw < 0.05), but the consistency analysis was inadequate to support the inference, with the MR-Egger method showing an opposite direction.

The median estimated h 2 SNP across all 3321 edges was 3.63% and nominally significant effects were found in 1083 edges (32.6% of total) with a median h 2 SNP of 6.2%.

As multiple of the exposures tested captured aspects of EBV infection and host response, this correction may have been overly stringent, and nominally significant associations remain biologically plausible.

We found two proteins FGF-21 and CCL25 significantly overexpressed in HU patients with gout compared to NU gout and another 8 nominally significant ( Figure 2 C).

In these analyses, a p-value range of 0.0127 ≤ p < 0.05 was considered as nominally significant.

In the largest dataset ( GSE15222 ), we observed nominally significant differences in SNAP25 expression between females and males among AD patients but not among controls.