“nominally significant”

Cytokine Production Enrichment Using nominally significant QTL’s we linked COVID-19 risk alleles to pathogenically stimulated cytokine production risk alleles.

Concurrent validity patterns were weak and non-robust, with group-level ANOVA yielding a nominally significant result that should not be interpreted as evidence of a meaningful anger–IGD association, given the composite and non-latent nature of the anger measure.

Nevertheless, there were a few nominally significant peaks for dominance or imprinting effects shown in the Manhattan plots, such as the peak for imprinting effect on chromosome 6 for somatic cell score (Additional file 2 : Figure S2C) and the one at the end of chromosome 10 for cow conception rate (Additional file 2 : Figure S2F).

The results of the statistical analyses for each test are summarized in Table S1 , in which values for nominally significant effects of Treatments are highlighted in yellow.

Gene selection with SMR and coloc Detection of nominally significant associations both for eQTL and with IBD at a single SNP does not necessarily imply that the SNP is responsible for both effects.

Notably, none of the regional volumes expressed in absolute terms (mm 3 ) had even nominally significant age-by-sex or age 2 -by-sex interaction effects.

Since three SNPs of the SLC1A2 gene demonstrated nominally significant associations, we carried out a haplotype analysis for these SNPs.

The interactions of the two PCSK9 SNPs with either E-alone or E+P alone are only nominally significant.

Nonetheless, mediation P values for all‐cause mortality remained significant or nominally significant for GDF15, UCMGP, B2M, and sICAM1.

The study found that after a median 3.2 years of follow-up, participants randomized to EQW had a numerically lower incidence of major adverse CV events (MACE) and a nominally significant reduction in all-cause mortality (ACM) [ 7 ].

Given the observational nature of the study and the risk of Type I error from multiplicity, nominally significant interactions in these exploratory analyses were interpreted with caution, with primary emphasis placed on the magnitude of associations and consistency of patterns rather than isolated P-values.

Often, those genes had nominally significant P -values in both analyses, but multiple testing correction rendered them non-significant for one of the two.

All results are summarised in Supplementary Table S12 and highlight that some nominally significant findings—particularly in small treatment-defined subgroups—may be imprecise and prone to overestimation. 3.3.7.

41 , 42 , 43 Significant thresholds To limit detection of false positives, metabolites of significant interest were defined as being nominally significant on two or more models or experiment wide significant on one model.

We used the Bayes False Discovery Probability (BDFP) to assist in the interpretation of each nominally significant association [ 23 ].

having “ikigai” and decisiveness, had a nominally significant association with breast cancer incidence 12 .

Among the 2465 CHIP variable-protein pairs being compared (493 proteins × 5 CHIP variables [ DNMT3A, TET2, ASXL1, JAK2 , and composite CHIP]), 30.8% was nominally significant in at least one of the SomaScan-based and Olink-based results.

Burden testing identified 21 genes with nominally significant p -values, providing further evidence that variation in these genes is likely deleterious for human male infertility (Supplementary Table 4 ).

However, even after adjustment, there were nominally significant reductions in symptomatic VTE and ACM as well as ACM alone.

The number of CNS cell types with nominally significant enrichment (29) was also larger than all other systems and organs.

Any difference observed between the groups where the p value was less than 0.05 by statistical testing should be regarded as nominally significant.

[16] identified 8 additional GSV loci with nominally significant association with obesity, on the basis of being present in children with “common” obesity (individuals with severe obesity were excluded from the study) but absent from control cohorts of normal weight.

The most significant variables included age (nominally significant for 12/23 cancer types) followed by tumour grade (for 2/4 cancer types for which the variable was available) and histological type (6/13 cancer types).

In total, 9 potentially significant MT-SNPs and 14,340 nominally significant MT-nuclear interactive SNPs were identified for AD, which were validated by functional analysis.

Finally, a nominally significant association was reported between a SNP in ALPK1 (MIM 607347) and both age at death and morbidity-free status at age 65 [85] .