“nominally significant”

Using this best-fit liability threshold model to calculate the sample sizes required to provide 80% power to detect a nominally significant difference in PRS at pT=0.05, indicated that apart from the comparison of PRS between 22q11.2DS individuals without psychosis and WTCCC controls, all other primary analyses of polygenic risk were sufficiently powered ( Table S6 ).

These discoveries were nominally significant at a reported FDR of 0.01, but the only known target among the 131 results was melA .

The locus marked by rs7780001 on chromosome 7p21.1 near FERD3L was genome-wide significant in the meta-analysis across ethnic groups (P value 2.0 × 10 −8 ; Figure 3 and Additional file 7 : Figure S5) and had nominally significant associations in all three ethnic groups.

Moreover, albeit the originally discovered rs1652507 × rs9458001 interaction term became non-significant, we observed nominally significant interactions of both rs1652507 and rs9458001 with rs140570886.

We therefore tested the genetic correlation between the UKBB phenotypes and their closest equivalents in AoU (self-report in UKBB vs self-report in AoU, and stringent ICD-10 in UKBB vs stringent ICD-10 in AoU) and found a nominally significant effect of r g = 0.77 between the self-report traits, and a significant effect for the stringent ICD-10 traits, with r g = 1.07 (Suppl.

Only FIL200 + MTX showed nominally significant higher odds vs MTX monotherapy; FIL100 + MTX and FIL200 monotherapy did not.

Comparison of traits and tests In all cases except one, the position of QTL mapped using half-sib regression analysis co-located within 10 cM of a nominally significant SNP in the GWAS analysis for the two traits.

Analysis of whole-genome sequencing variant data revealed that gene ontology terms related to development and differentiation such as ‘skeletal system morphogenesis’, ‘embryonic morphogenesis’, and ‘sensory organ development’ were nominally significant in non-coding regions.

A p value of less than 0.05 was considered nominally significant.

Both ATO groups had statistically significant improvements from baseline across the 12-week treatment period in AIM-D PDA ( Figure ) and PI domain scores ( P <.01), and nominally significant improvements at weeks 1-4, weeks 5-8, and weeks 9-12 (only for 30mg BID) for both AIM-D domains vs placebo.

Nominally significant SNPs for T2D were replicated in stage-2 and stage-3 studies.

The most significant SNPs of the gene detected/imputed in our GWAS sample did not achieve nominally significant p values in the UK sample ( Table 4 ), although the use of different genotyping platforms may be partly responsible.

Linear regression models were fitted with Δ outcome as the dependent variable and ΔExposureas the predictor, including group as a covariate and testing effect modification using a Group × ΔExposure interaction term; where the interaction was nominally significant or borderline, group-specific slopes are reported. 3.

Of those 14 known variants or proxies, rs2075633 was nominally significant in our meta-analysis results and directionally consistent in both phases [OR SNP (95% CI) = 1.37 (1.06, 16.85), p SNP = 0.016).

For the two AMPS-2 nominally significant results the R 2 values of approximately 10%, suggesting that these PRSs could potentially be useful clinically.

Nominally significant interactions were observed for the two SNPs in the 1p12 locus, again with a larger effect in females ( P interaction = 0.049 for rs146953046; P interaction = 0.034 for rs532303).

51 , 127 A nominally significant association with ADHD remains upon exclusion of ASD and SCZ affected individuals, 55 indicating that the condition can arise independently of the latter diagnoses.

For five of these signals (the primary signal near CDKN2A /B plus those in CDKAL1 , HHEX , NOTCH2 , and SLC30A8 ), there was some evidence that the association signal was more marked in nonobese case subjects, but this effect was only nominally significant for rs13266634 in SLC30A8 ( P DIFF = 0.04).

Functional annotation and gene-mapping of genomic risk loci Functional annotation and gene-mapping of genomic risk loci was performed using the Functional Mapping and Annotation (FUMA) online tool, version v1.3.5e ( http://fuma.ctglab.nl [ 51 ]), including all nominally significant SNPs that were in LD ( r 2 ≥ 0.6) with one of the independent genome-wide significant SNPs from the sociability GWAS.

In conclusion, there were nominally significant interactions between ABCB1 genotype and preoperative statin use on clinical outcomes, while preoperative statin use was not associated with outcomes.

Nominally significant improvements in the change from baseline in morning pre-dose trough FEV 1 over Weeks 12–24 were observed for BGF MDI vs GFF MDI (least squares mean [LSM] difference 37 mL, 95% confidence interval [CI] 3, 72; P =0.0337) and BFF MDI (67 mL; 95% CI 25, 109; P =0.0020).

Negative Causal Effect of Cognition on Lipid-Related Metabolites A nominally significant causal effect of cognition on 18 lipid-related metabolites was observed.

6 metabolites (Table) and 154 lipids had nominally significant p values (<0.05).

Follow on MR identified two CpGs (cg11024682 in SREBF1 , and cg07730360, unannotated) with nominally significant putative causal effects of DNA methylation on BMI.

Values between 0.05 and 0.08 were deemed nominally significant. 3 Results 3.1 Instrumental variables Following screening, we initially incorporated 30 SNP instrumental variables for depression and 50 SNP instrumental variables for MDD.