“nominally significant”

By using as input the top SNP on each of the five credible sets ( Table 1 ), we identified a nominally significant enrichment of enhancers (as defined by the 15-state core ChromHMM model) in foreskin melanocytes (binomial test compared with all 1KGP variants with MAF ≥5%; p value = 0.0169).

Under the additive model, the effect of p.(Arg162Ter) on twinning is nominally significant (OR = 1.46, P = 0.017), but does not meet our threshold for statistical significance after accounting for multiple testing (Supplementary Table 5 ).

A nominally significant association was found between ADHD and maternal diseases, χ 2 (1, N = 497) = 5.67, p = 0.017, OR = 1.84, 95 % CI 1.11–3.04.

In accordance with the trend in the previous analysis, we found a higher AR gene load in bacteria from AB+ infants, with nominally significant results ( p = 0.017; Figure 2 C; Table S4 C).

There were no significant differences in the rates of non-SARS-CoV-2 infection, thrombotic events, or clinically significant bleeding, but allocation to baricitinib was associated with a nominally significant reduction in new onset cardiac arrythmia (2·3% vs 3·2%, p=0·017; appendix p 58 ).

General malaise and diarrhea showed nominally significant associations ( p = 0.017 and p = 0.023, respectively) with lower OD levels.

Additionally, there was a nominally significant group difference in the relationship between glutamate concentration and both connectivity within the DMN (Std. beta = 0.5, 95% CI [0.1, 0.91], t (29) = 2.53, p = 0.017) and connectivity between the DMN and central executive network (Std. beta = 0.41, 95% CI [0.04, 0.78], t (29) = 2.28, p = 0.03).

A 2026 study by Candido et al in Italian patients with T2D receiving GLP-1RA therapy reported GLP1R rs6923761 frequencies consistent with broader Southern European estimates (MAF 18.3%) and identified a nominally significant association between Ser168 carrier status and greater 12-month weight loss (−3.2 kg, 95% CI −5.8 to −0.6 kg, P = .017) [ 62 ].

In the discovery cohort, a nominally significant difference in DFS was observed among patients ≤ 50 years ( p = 0.017), with a point estimate suggesting higher hazard in ever‐smokers; however, this was based on only 11 events and was not replicated in the validation cohort.

CAPS-5 avoidance symptoms showed a nominally significant decrease in the MBCT group ( F [1, 68.10] = 5.98, p = .017; t [71.60] = 3.61, p < .001).

However, results of the enriched Amerindian or African variants’ interaction with APOE -ɛ4 on MCI analysis, the BinomiRare test identified one nominally significant interaction between an African enriched variant, rs8112679, and APOE -ɛ4 on MCI ( p -value = 0.017) (Table 4 ).

Three intronic variants of XDH gene were nominally significant, including rs513311 (intron 3) (OR = 2.10, 95% CI = 1.14–3.85, P = 0.017; rs561525 (intron 9) (OR = 2.18, 95% CI = 1.04–4.59, P = 0.040), and rs2163059 (intron 12) (OR = 0.75, 95% CI 0.58–0.96, P = 0.026).

We also found nominally significant associations between KGL and the relative abundances of Escherichia coli ( p = 0.017, p -adjust = 0.173) and Ruminococcus torques ( p = 0.025, p -adjust = 0.173), while KTG was enriched in Bacteroides xylanisolvens ( p = 0.044, p -adjust = 0.173), though these comparisons did not survive FDR correction ( Figure 3 C, Table S4 ).

However, we found a nominally significant enrichment (i.e., more observed dnSNVs than expected) of splice site dnSNVs ( p = 0.0173, BH-FDR = 0.0519, enrichment ratio = 5.60).

A nominally significant association between the 5-HTTLPR and increased suicidal risk ( p -value = 0.0174) was found with the S -allele being protective and the L -allele being a risk factor for suicidality.

15 324.4) and yielded a nominally significant block test (ΔRSS = 1 338.5, F(6,2085) = 2.565, p = 0.0177).

We found a nominally significant association of the stop-gain variant (T allele) with lower grip strength (additive: β =−0.062 kg, P =0.018) ( Supplementary Table 9 ) although we found no evidence for any departure from an additive genetic model at this locus ( P domdev = 0.72; Supplementary Fig. 5 ).

In the comparison of the control group versus ACL injury, rs1042631 showed nominally significant associations under the codominant ( p = 0.018), recessive ( p = 0.024, OR = 0.15, 95% CI: 0.02–1.22), and overdominant ( p = 0.035, OR = 2.02, 95% CI: 1.05–3.87) models.

First, the previous GWAS of FI (Mekli et al., 2018 ) identified 2 variants; however, neither were associated with FI: rs6765037 ( p = 0.410), although rs7134291 was nominally significant ( p = 0.018).

However, the association was only significant for the PSP-S (OR = 8.13, CI: 2.77–22.99, Fisher’s exact test, P = 8.43 × 10 −5 ) cohort and nominally significant for the FTD (OR = 3.35, CI: 1.08–9.79, Fisher’s exact test, P = 0.0180) cohort.

Two CpG units had nominally significant case–control differences in methylation, CpG 14 ( Z = −2.37, p = 0.018) and 9,10 (Z = −2.017, p = 0.044); at each of the significant CpG units, cases had higher MMFs than controls.

5d and Table S13 ) indicate that, among the three traits, only whole-body fat-free mass has a nominally significant causal effect on UL risk ( p = 0.018) and, thus, support the original findings.

The two variants were not genome-wide significant in our study, but nominally significant into the same direction (p = 0.018 and p = 0.003).

For volume LQ, there was a nominally significant effect ( t (294) = 2.38, p = 0.018), indicating that left-handers (1.21, SD = 3.58) had a more positive LQ than right-handers (−0.49, SD = 3.48).

In septic shock patients, only the comparison between high- and low-intensity NUF remained nominally significant (aHR 1.88, 95% CI 1.12–3.17, p = 0.018), which also did not meet the corrected significance threshold.