“nominally significant”

All three index SNPs showed nominally significant association (p value < 0.016) in this second Colombian cohort, with the strongest signal being observed for rs115943328 in NCX3 (p value 3 × 10 −5 ).

A nominally significant association with cancer overall was observed for homozygosity at HLA-DQB1 locus (adjusted OR = 1.08, 95% CI = 1.01–1.15, P = 0.016, Table 2 ).

We also observed nominally significant associations of several genes with CAD: LPL [ 29 , 60 ] (OR = 1.168; CI 1.034–1.036; P = 0.016), NOS3 [ 15 ] (OR = 1.143; 95% CI 1.109–1.279; P = 0.02), and ADAMTS7 [ 32 ] (OR = 1.062; 95% CI 1.011–1.115; P = 0.016) (Supplementary Tables 9–10).

In Period 1–6, the SIDD subgroup had 12% (2; 22) lower HOMA2-B value (reflecting insulin secretion at fasting) than controls ( ESM Figure S6B, S21 ), but the difference was only nominally significant (p = 0.016).

Association tests adjusted for age and sex revealed a nominally significant association using logistic regression between AMD and three SNPs ( DAPL1 : rs17810398:C>T, P = 0.016; RP1 : rs9643828:T>C, P = 0.037; CST3 : rs2424577:C>T, P = 0.028) (Supplementary Table S2).

For rs6983267G, we also found a nominally significant association with TC risk (p=0.016, OR=1.14, 95% CI 1.02 to 1.27, equivalent false discovery rate=0.020).

After correcting for multiple comparisons (Holm-Bonferroni), stepwise improvements in balanced metrics (F1 score and MCC) remained statistically robust across both internal and external cohorts, whereas the observed increases in AUC and sensitivity-focused F2 score—although nominally significant in certain cases (e.g., external cohort AUC nominal P = 0.016)—did not consistently survive multiple testing correction.

Methylation of cg01965508 at the PIGR locus showed a nominally significant negative association with smoking ( P = 0.016).

For example, ARID1A , which is part of the ATP-dependent chromatin remodeling complex SNF/SWI, was associated with sensitivity to topotecan, a DNA topoisomerase I inhibitor, in STAD ( P BH = 1.68 × 10 −3 ) and nominally significant in UCEC (raw P = 0.016).

We did observe a nominally significant ( p = 0.016 Wilcoxon rank sum test) greater functional impact for HcDNV inhibitors in ASD cases than controls ( Figure 2 D–F), though this did not survive correction for the four equivalent conditions, so does not constitute evidence of a functional effect based on ASD diagnostic status ( Supplementary Note S1 and Figure S5 ).

Consideration of findings reaching a level of nominally significant (α < 0.05) results revealed that—with increasing sample size—anthropometric risk factors such as high waist-to-hip ratio (r g = 0.30, P = 0.016) may correlate with genetic risk of ASB.

Furthermore, the depression scale (GDS-d) also showed a nominally significant difference between the UCB + EPO and control groups (Δ-3.00 [-5.00, -2.00] vs. Δ6.00 [-1.00, 18.50], P = 0.016) (Table 3 ).

Among the top suggestive novel genes identified in Whites based on the ImmunoChip data, FCGR2C and PINX1 were only nominally significant in African Americans (p = 0.016 and p = 0.028, respectively), while among the top novel genes identified in the gene-level analysis in African Americans, UNC5C (p = 5.57x10 -4 ) and CLEC16A (p = 0.0463) were also nominally significant in Whites.

reports a nominally significant association between this SNP and decreased AD risk (β = −0.097, P = 1.6 × 10 −2 ; examined using the proxy SNP, rs2835569‐T, r 2 = 0.94, D′ = 0.98; Figure 4F ). 34 We observed a similar trend of an AD protective effect in the Niigata cohort (β = −0.063, P = 0.413; Figure 4F ).

2 A, B, D, E and Table 1 ) was associated with a nominally significant increased risk of ASD (OR = 1.06, 95% CI: 1.01–1.12, P = .016, false discovery rate (FDR) = 0.677) and ADHD (OR = 1.09, 95% CI: 1.01–1.18, P = .026, FDR = 0.234).

SNPs from cluster 2 also displayed a nominally significant increase in the risk of stroke ( P -value = 1.6x10 -2 ).

The magnitude of the association with lower FEV 1 increased to some extent in older groups, but only a nominally significant trend in the association effect size across age groups was found ( p = 0.016).

The considered measures of epigenetic AgeAccel exhibit nominally significant positive correlations with motor progression (e.g., r = 0.08, meta-analysis p = 0.016 for the pan-tissue clock; Supplementary Table 8 and Supplementary Fig. 7 ).

When conducting exploratory analyses for specific CpG sites and all types of trauma (Supplementary Table 1 ), we observed a nominally significant negative association between DNA M at CpG 2 and CTQ summary score ( r = −0.171, p = 0.016), physical abuse ( r = −0.168, p = 0.018) and emotional abuse ( r = −0.172, p = 0.015).

Although the weighted median estimator showed a nominally significant result (OR = 0.979, 95% CI: 0.964–0.996, p = 0.016), the effect size was small and not consistent across all methods ( Figure 6 ).

We observed a nominally significant linkage signal for RBL2 expression (logarithm of odds [LOD] score = 0.997, P = 0.016; n = 1,240) but not FTO expression directly at the RBL2-FTO locus ( Fig. 2 ), indicating that only RBL2 expression is likely to be affected by genetic variation in this region.

Moreover, the frequency of A allele was higher in the PTSD patients than in the control subjects, although at a nominally significant level ( p = 0.016) ( Table 1 ).

A complex pattern emerged for Dimethylarginine (SDMA + ADMA) and glutaroyl carnitine: IVW analysis showed nominally significant reverse associations ( p -value = 0.0163 and 0.0276), but Steiger tests strongly rejected the reverse direction ( p -value = 0.0011 and 0.0021).

Similarly, a nominally significant distribution shift was observed in hypothalamus tissue using the gene set implicated in sporadic PD ( P = 0.0163).

3.3 Identification of differentially expressed miRNAs Of the sixteen reliably detected miRNAs, three, miR-15b, miR-132, and miR-652, showed a nominally significant increase in expression in the high-risk subjects compared to the control subjects (miR-15b: p = 0.0166, fold-change (FC) = 1.29; miR-132: p = 0.0249, FC = 1.34; miR-652: p = 0.0108, FC = 1.26; Fig. 1 ; Table 2 ).