“nominally significant”

On the basis of a deeper examination of nominally significant SNPs, ISC proposes a common polygenic variant model for schizophrenia.

Measures of Aβ pathology show nominally significant, but less robust associations with disease and cognitive status ( Figure 2B–D , bottom row), aligning with previous reports that pTau may be a better indicator of AD severity than Aβ ( Nelson et al., 2007 ).

A couple of nominally significant interactions modulating the continuous trait of FPG were observed in START were not confirmed in BiB and vice versa.

Interestingly, among 18 genes that contain FERM domains, including several members of the 4.1 protein family, we identified nominally significant associations with diabetic nephropathy for SNPs located in eight of these genes (supplementary Table 5), including FARP2 (FERM, RhoGEF and pleckstrin domain protein 2; P = 3.0 × 10 −4 ) and EPB41L2 (erythrocyte membrane protein band 4.1-like 2; P = 2.3 × 10 −4 ).

3.3 Relationship between stress and CRP Childhood trauma as measured by CTQ total score, and all subscale scores showed nominally significant positive correlations with CRP levels in both patients (N = 72) and controls (N = 39).

The study of a larger gene array with 39,000 transcripts in mice [ 29 ] reported 4,474 genes with nominally significant expression changes and 121 with a stringent Bonferroni correction.

We did not replicate the differences in the Bifidobacterium genus showing the largest (nominally significant) difference between the ADHD group and controls by Aarts et al., even though this sample overlaps with the current sample (around 40%).

199 found significant associations between DCDC2 -READ1 and brain activations in the left antero-inferior parietal lobe and in the right lateral occipital temporal gyrus during reading tasks, and a nominally significant association between DCDC2 d and activation in the left antero-inferior parietal lobule.

Nominally significant associations with rs8067235 were also apparent in the analysis of classical performance measures that can be related to negative modulation of memory but are less specific than ε neg ( Table S2 ).

The supplementary tables show the relevant demographic and clinical features of cases and controls used for the GWAS of sepsis risk and for the GEN-SEP patients, the list of previous candidate genes associated with sepsis risk, the prioritized independent SNPs, the index bias event results, the association results with 28-day mortality and the percentage of variation explained by the sentinel SNPs by separate or as part of a PRS, the association results of the sentinel variants from other sepsis mortality GWAS studies, the nominally significant results for the classical HLA alleles and amino acids, and the functional assessment of variants associated with 28-day sepsis survival.

Nominally significant meta-data variables were added to a single permutational multivariate analysis of variance model to identify overall effect sizes.

Specifically, 11 of the 22 genes upregulated in resistant models and 23 of the 40 genes upregulated in sensitive models demonstrated nominally significant associations with the magnitude and direction of treatment response across the entire cohort (Supplementary Fig.

[Note that the signal and RMA values that remove similar numbers of probe sets are quite different for the vitamin A data than for the IFN data.] Increasing the stringency of filtering decreases the number of probe sets with nominally significant p-values, as expected, but the more significant probe sets (p ≤ 0.01 and p ≤ 0.001) are the least affected (Fig. 4 , Table 2 ).

Although our meta-analysis identified a nominally significant association between the MTHFR C677T polymorphism and CSVD, we recognize the need to interpret these findings within clinical practice.

However, in the context of the present study the results of the early AMD phenome-wide screen were considered significant only if they remained: significant after false discovery rate (FDR) correction in the MRE IVW; nominally significant in weighted mode and weighted median; and nominally significant throughout the leave-one-out analysis (MRE IVW) ( Benjamini and Hochberg, 1995 ).

For tests of primary research questions, we consider findings with a p -value smaller than 0.05 as nominally significant and findings with a p -value smaller than 0.0125 (0.05/4 anhedonia subscales) as statistically significant after correction for multiple testing.

Resulting nominally significant CNVRs were excluded if they met any of the following criteria: i) residing on telomere or centromere proximal cytobands; ii) arising in a “peninsula” of common CNV arising from variation in boundary truncation of CNV calling; iii) genomic regions with extremes in GC content which produces hybridization bias; or iv) samples contributing to multiple CNVRs.

The novel genes, PLIN2 and LACTB2 , showed reduced evidence for TWAS association in the Marioni dataset, although LACTB2 showed a nominally significant association in LPS24 ( Table 1 ; Supplementary Fig. 4 ).

There were several population-specific phenotypic markers whose frequencies increased in the presence of either THBS1 or IL1B and were associated with lower reservoir size that were nominally significant (Supplementary Table 5).

Nominally significant correlations with SMM were observed for IL-17, β-NGF and TRAIL; however, these associations did not survive correction for multiple testing and should therefore be considered exploratory.

Note that all the gene sets selected in this way have nominally significant p-values (within a range of 0 − 0.017).

With the matching analyses ( Supplementary Figure 1 A), significantly lower performances in executive functions were only observed in one cognitive test (Trail-Making-Test, TMT); the difference in visuo-constructive abilities was only nominally significant.

The general trend of statistical significance showed that transcripts which were identified as DTU events by at least one of the methods were likely to be defined at least as nominally significant by the alternative method: 97% of all DRIMSeq DTU events were nominally significant according to DEXSeq and 98% of all DEXSeq DTU events were reported as nominally significant by DRIMSeq.

We identified 43 nominally significant sequence variants in PIAS2 , JAK2, TYK2 , and AKT1 (Table 1 ) that were associated with sPD patients.

60 In the phase 2a biomarker study, a nominally significant improvement in MMN and a statistical trend toward improvement for the ASSR were observed. 71 This result is consistent with enhanced NMDAR activity and suggests that luvadaxistat treatment has the potential to improve the auditory processing circuits that are impaired in schizophrenia. 72-74 Furthermore, this finding is reminiscent of the improvements in MMN observed with D-serine treatment, as described in Section 2.