“nominally significant”

Accordingly, nominally significant findings should be interpreted with caution and require confirmation in larger cohorts.

p values of < 0.05 were considered nominally significant.

Nominally significant associations are presented in Table 4 .

For each transcript, the algorithm counts the number of experiments where the significance for differential expression is < 0.05, then generates the binomial probability, referred to as the consensome p -value (CPV), of observing that many or more nominally significant experiments out of the number of experiments in which the transcript was assayed, given a true probability of 0.05.

(TIF) S12 Fig Nominally significant TRZ response genes show enrichment in cancer-related pathways.

p-values of <0.05 were reported as nominally significant.

The genetic correlation with older age cognitive function was .11 (nominally significant but did not survive correction for multiple testing) and was not very different from that of .17 for educational attainment.

Considering the high correlations among changes in individual BA subtypes [ 22 ], crude P <0.05 was regarded as nominally significant.

We also found nominally significant negative ρ AρEC values in the majority of liver (3/4) and lung (3/3) datasets, and in 2/5 artery datasets.

Since our p values relative to the rank test p values remained nominally significant when using a statistically less powerful but more robust test (data not shown), we can confirm that our small sample size and the deviation from normality do not alter the main findings/conclusions presented in this paper.

Topiramate response PGS had nominally significant associations with lower rates of alcohol‐related liver disease, older age at alcohol use disorder diagnosis, and higher frequency of alcohol use.

Seven biologically plausible new loci showed nominally significant associations with variants in regions neighboring NFIA , LTBP1, CD200R1 , ELMO1 , SPRY2 , VAV1 , and MX1 .

[ 28 ] found that rs6453267, rs7728378, and rs10474485 showed a nominally significant interaction with the continuous CTQ score to predict SA.

With respect to education years, a nominally significant group difference between the genotype groups was observed for rs2037639 (Additional file 1 : Table S1).

22 showed that the patients carrying 27 bp‐VNTR exhibited a nominally significant association with cardiovascular measures after adjusting for trait‐specific covariate effects.

In an independent cohort of 67 autopsy-proven CBD cases from the Mayo Clinic Florida Brain Bank and 457 control individuals, a replication stage was performed for a total of seven SNPs: the top five SNPs from the discovery stage ( P <10 −5 ) and two PSP GWAS SNPs that showed nominally significant association with CBD (rs1768208 and rs242557) ( Table 2 ).

Formal interaction tests supported effect modification by age group for the any-disorder phenotype and affective disorders, with nominally significant interactions for psychosis and behavioural syndromes ( online supplemental table S10 ).

rs1328363 is also a sc-ASCA and nominally significant sc-caQTL of its residing OCR and a nominally significant sc-eQTL of GPC6 , specifically in Rod.

Therefore, nonsignificant results should not be interpreted as evidence of equivalence, and some nominally significant findings warrant cautious interpretation.

These changes from baseline were associated with nominally significant p ‐values from the 12‐month mark onwards.

In this respect, here we reanalyze three metaanalysis data of GWAS in T2D, using the methodology that we have developed to identify disease-associated pathways by combining nominally significant evidence of genetic association with the known biochemical pathways, protein-protein interaction (PPI) networks, and the functional information of selected SNPs.

We observed nominally significant P -values for the association of some loci with HD residual age-at-onset ( Supplementary Table 1 ), but when these were corrected for the gene size and number of SNPs in the region, none remained statistically significant.

Three hundred and five nominally significant association signals were distributed from the HLA-A to HLA-DP loci in accordance with the results of the HLA association analysis (Fig. 1A ).

Among the genes in the glutamatergic neurotransmission system, GRIN2B , an the NMDA (N-methyl-D-aspartate) glutamate receptor, emerged as one of the genes relevant to OCD and SRI response with some nominally significant SNPs.

Convincing evidence in support of a significant causal effect of drinks per week and suggestive evidence for a nominally significant causal effect of PAU with CRC were observed.